Update review on five top clinical applications of human amniotic membrane in regenerative medicine

Nejad, Aida Rezaei; Hamidieh, Amir Ali; Amirkhani, Mohammad Amir; Sisakht, Mahsa Mollapour

doi:10.1016/j.placenta.2020.10.026

Cited by 42 publications

(30 citation statements)

References 89 publications

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“…In the last years, progress has been made in the field of basic knowledge regarding the antimicrobial activity of fetal membranes (King et al, 2007a,b;Klaffenbach et al, 2011). Since the use of fetal membranes in tissue engineering and regenerative medicine is increasing (Lim, 2017;Nejad et al, 2021) and microbial infections represent a crucial complication in various treatments (Ikada, 2006;Kuijer et al, 2007;Guo and Dipietro, 2010;Deptuła et al, 2019), antimicrobial properties of fetal membranes are attracting more and more attention. In this review, we focus on the biological function of hACM, hAM, and hCM, their antimicrobial properties, and the potential of their use in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use

Ramuta

Sket

Erjavec

et al. 2021

Front. Bioeng. Biotechnol.

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The fetal membranes provide a supportive environment for the growing embryo and later fetus. Due to their versatile properties, the use of fetal membranes in tissue engineering and regenerative medicine is increasing in recent years. Moreover, as microbial infections present a crucial complication in various treatments, their antimicrobial properties are gaining more attention. The antimicrobial peptides (AMPs) are secreted by cells from various perinatal derivatives, including human amnio-chorionic membrane (hACM), human amniotic membrane (hAM), and human chorionic membrane (hCM). By exhibiting antibacterial, antifungal, antiviral, and antiprotozoal activities and immunomodulatory activities, they contribute to ensuring a healthy pregnancy and preventing complications. Several research groups investigated the antimicrobial properties of hACM, hAM, and hCM and their derivatives. These studies advanced basic knowledge of antimicrobial properties of perinatal derivatives and also provided an important insight into the potential of utilizing their antimicrobial properties in a clinical setting. After surveying the studies presenting assays on antimicrobial activity of hACM, hAM, and hCM, we identified several considerations to be taken into account when planning future studies and eventual translation of fetal membranes and their derivatives as antimicrobial agents from bench to bedside. Namely, (1) the standardization of hACM, hAM, and hCM preparation to guarantee rigorous antimicrobial activity, (2) standardization of the antimicrobial susceptibility testing methods to enable comparison of results between various studies, (3) investigation of the antimicrobial properties of fetal membranes and their derivatives in the in vivo setting, and (4) designation of donor criteria that enable the optimal donor selection. By taking these considerations into account, future studies will provide crucial information that will enable reaching the optimal treatment outcomes using the fetal membranes and their derivatives as antimicrobial agents.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use

Ramuta

Sket

Erjavec

et al. 2021

Front. Bioeng. Biotechnol.

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“…Preclinical studies with the application of DAM in dentistry have been developed in bone with ASCs [ 34 ], in oral mucosa with oral epithelial cells [ 35 ], in periodontal tissue engineering with periodontal ligament cells [ 36 , 37 ], and with a dental pulp-derived cell sheet [ 38 ]. Amnion and its products have been used in clinical trials of periodontal diseases treatment and surgery [ 39 ] and clinically to treat gingival recessions [ 40 ]. Autologous transplantation of epithelial cells associated with DAM has been used to treat mucosal defects [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Dziedzic¹,

Mogharbel²,

Irioda³

et al. 2021

Membranes

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Periodontitis is a prevalent disease characterized by the loss of periodontal supporting tissues, bone, periodontal ligament, and cementum. The application of a bone tissue engineering strategy with Decellularized Human Amniotic Membrane (DAM) with adipose-derived stromal cells (ASCs) has shown to be convenient and valuable. This study aims to investigate the treatments of a rat periodontal furcation defect model with DAM, ASCs, and a mineralized extracellular matrix (ECM). Rat ASCs were expanded, cultivated on DAM, and with a bone differentiation medium for four weeks, deposited ECM on DAM. Periodontal healing for four weeks was evaluated by micro-computed tomography and histological analysis after treatments with DAM, ASCs, and ECM and compared to untreated defects on five consecutive horizontal levels, from gingival to apical. The results demonstrate that DAM preserves its structure during cultivation and healing periods, supporting cell attachment, permeation, bone deposition on DAM, and periodontal regeneration. DAM and DAM+ASCs enhance bone healing compared to the control on the gingival level. In conclusion, DAM with ASC or without cells and the ECM ensures bone tissue healing. The membrane supported neovascularization and promoted osteoconduction.

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“…Therefore, its support function is emphasized by the development of hAM composites and commercial products [9,31,32,36]. The use of hAM cells in the TE field is more sporadic [37].…”

Section: Introductionmentioning

confidence: 99%

Applications of Human Amniotic Membrane for Tissue Engineering

et al. 2021

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An important component of tissue engineering (TE) is the supporting matrix upon which cells and tissues grow, also known as the scaffold. Scaffolds must easily integrate with host tissue and provide an excellent environment for cell growth and differentiation. Human amniotic membrane (hAM) is considered as a surgical waste without ethical issue, so it is a highly abundant, cost-effective, and readily available biomaterial. It has biocompatibility, low immunogenicity, adequate mechanical properties (permeability, stability, elasticity, flexibility, resorbability), and good cell adhesion. It exerts anti-inflammatory, antifibrotic, and antimutagenic properties and pain-relieving effects. It is also a source of growth factors, cytokines, and hAM cells with stem cell properties. This important source for scaffolding material has been widely studied and used in various areas of tissue repair: corneal repair, chronic wound treatment, genital reconstruction, tendon repair, microvascular reconstruction, nerve repair, and intraoral reconstruction. Depending on the targeted application, hAM has been used as a simple scaffold or seeded with various types of cells that are able to grow and differentiate. Thus, this natural biomaterial offers a wide range of applications in TE applications. Here, we review hAM properties as a biocompatible and degradable scaffold. Its use strategies (i.e., alone or combined with cells, cell seeding) and its degradation rate are also presented.

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Update review on five top clinical applications of human amniotic membrane in regenerative medicine

Cited by 42 publications

References 89 publications

Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use

Antimicrobial Activity of Human Fetal Membranes: From Biological Function to Clinical Use

Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Applications of Human Amniotic Membrane for Tissue Engineering

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