Updates in Pediatric Tuberculosis in International Settings

Shakoor, Sadia; Mir, Fatima

doi:10.1016/j.pcl.2021.09.004

Cited by 7 publications

(1 citation statement)

References 86 publications

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“…In some cases, a worsening can be observed at the first X-ray control, despite the presence of an evident improvement in the clinical picture. In these cases, it is advisable to repeat the X-ray after 1–2 months and at the end of therapy [ 106 ].…”

Section: Diagnosismentioning

confidence: 99%

Pulmonary Tuberculosis in Children: A Forgotten Disease?

Pelosi¹,

Pintus

Savasta

et al. 2023

Microorganisms

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Even today, tuberculosis in childhood is a disease that is often undiagnosed and undertreated. In the absence of therapy with antituberculosis drugs, children in the first years of life have a high degree of severe forms and mortality. In these children, symptoms are often not very specific and can easily be confused with other diseases of bacterial, viral or fungal etiology, making diagnosis more difficult. Nevertheless, the introduction of new diagnostic techniques has allowed a more rapid identification of the infection. Indeed, Interferon gamma release assay (IGRA) is preferred to the Mantoux, albeit with obvious limitations in children aged <2 years. While the Xpert Mtb/RIF Ultra test is recommended as an initial diagnostic investigation of the gastric aspirate and/or stools in children with signs and symptoms of pulmonary tuberculosis. The drugs used in the treatment of susceptible and resistant TB are the same as those used in adults but doses and combinations are different in the pediatric age. In children, brief therapy is preferable in both the latent infection and the active disease, as a significant reduction in side effects is obtained.

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Section: Diagnosismentioning

confidence: 99%