Updates on the worldwide burden of amoebiasis: A case series and literature review

Nasrallah, Jad; Akhoundi, Mohammad; Haouchine, Djamal; Marteau, Anthony; Mantelet, Stéphane; Wind, Philippe; Bénamouzig, Robert; Bouchaud, Olivier; Dhôte, Robin; Izri, Arezki

doi:10.1016/j.jiph.2022.08.013

Cited by 22 publications

(11 citation statements)

References 226 publications

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“…Males appear to acquire amebiasis at an earlier age than females. Our results agree with those of the previous Jordanian (Nawafleh et al, 2014) and global studies (Nasrallah et al, 2022). Collectively, these studies demonstrate a correlation between age and male sex with amebiasis.…”

Section: Discussionsupporting

confidence: 93%

Amebiasis: An Analysis of Its Distinctive Presentation in the Context of Jordanian Cases

Al-khlifeh,

Hasanat

2023

Preprint

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Amebiasis is a serious health problem, particularly in economically disadvantaged countries. However, unresolved questions remain regarding the clinical symptoms and laboratory results of amebiasis in Jordan, a developing country. Therefore, we assessed the prevalence and severity of amebiasis in a sizable population in the center of Jordan in relation to potential risk variables such as environment, age and sex of the patients, collecting data from the medical records of the patients treated at the Al-Hussein Hospital in Al-Salt city between 2020 and 2022. Clinical manifestations and laboratory findings, including fecal red blood cell and leukocyte counts, total and differential leukocyte counts by age, and other information were included in this report. This study showed that amebiasis is a common problem in Al-Salt city, accounting for 16.8% of all gastroenteritis cases. Amebiasis affects individuals of all sexes and ages. When comparing males of different ages to females of similar ages, both age and male sex showed an increased risk of amebiasis (P=0.014). Infants and toddlers accounted for more than one-quarter of the cases, with more than half of them diagnosed with watery diarrhea. Numerous patients of all age groups displayed age-related neutrophilic leukocytosis and atypical WBC counts. The findings of this study suggest that amebiasis is highly prevalent, affects a significant proportion of infants and toddlers, and causes severe clinical symptoms. This is the first study on Al-Salt city population with respect to multiple variables and demographic factors. These data are crucial for the decision-making of medical professionals. The epidemiology of amebiasis in Jordan must be determined, and preventive measures must be developed, especially for childcare at educational facilities.

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Section: Discussionsupporting

confidence: 93%

Amebiasis: An Analysis of Its Distinctive Presentation in the Context of Jordanian Cases

Al-khlifeh,

Hasanat

2023

Preprint

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“…The Indian subcontinent, Africa, Mexico, Central and South America, and Africa are among the regions with high rates of amebiasis[ 3 - 5 ]. In developed countries, immigrants from endemic areas account for the majority of cases[ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Amebic liver abscess: An update

Kumar,

Patel,

Priyadarshi

et al. 2024

World J Hepatol

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Amebic liver abscess (ALA) is still a common problem in the tropical world, where it affects over three-quarters of patients with liver abscess. It is caused by an anaerobic protozoan Entamoeba hystolytica , which primarily colonises the cecum. It is a non-suppurative infection of the liver consisting primarily of dead hepatocytes and cellular debris. People of the male gender, during their reproductive years, are most prone to ALA, and this appears to be due to a poorly mounted immune response linked to serum testosterone levels. ALA is more common in the right lobe of the liver, is strongly associated with alcohol consumption, and can heal without the need for drainage. While majority of ALA patients have an uncomplicated course, a number of complications have been described, including rupture into abdomino-thoracic structures, biliary fistula, vascular thrombosis, bilio-vascular compression, and secondary bacterial infection. Based on clinico-radiological findings, a classification system for ALA has emerged recently, which can assist clinicians in making treatment decisions. Recent research has revealed the role of venous thrombosis-related ischemia in the severity of ALA. Recent years have seen the development and refinement of newer molecular diagnostic techniques that can greatly aid in overcoming the diagnostic challenge in endemic area where serology-based tests have limited accuracy. Metronidazole has been the drug of choice for ALA patients for many years. However, concerns over the resistance and adverse effects necessitate the creation of new, safe, and potent antiamebic medications. Although the indication of the drainage of uncomplicated ALA has become more clear, high-quality randomised trials are still necessary for robust conclusions. Percutaneous drainage appears to be a viable option for patients with ruptured ALA and diffuse peritonitis, for whom surgery represents a significant risk of mortality.With regard to all of the aforementioned issues, this article intends to present an updated review of ALA.

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“…Amebiasis is endemic to countries in Asia, Africa, and Central and South America. Intestinal and hepatic amebiasis is endemic in Venezuela [ 4 ]. Presenting symptoms are vague and include abdominal pain, diarrhea, weight loss, and fever.…”

Section: Introductionmentioning

confidence: 99%

A Case of Entamoeba histolytica Liver Abscess in an Immigrant Patient

Balaji,

Ignatowicz,

Bhushan

et al. 2024

Cureus

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Entamoeba histolytica is a pathogenic protozoan endemic to Asia, Africa, and Central and South America. However, with increased travel and emigration, it is becoming a common parasitic infection leading to many worldwide deaths. We present a case of a young Hispanic male immigrant with an amebic liver abscess. This case report highlights the complexities of diagnosing and treating E. histolytica infection.

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Updates on the worldwide burden of amoebiasis: A case series and literature review

Cited by 22 publications

References 226 publications

Amebiasis: An Analysis of Its Distinctive Presentation in the Context of Jordanian Cases

Amebiasis: An Analysis of Its Distinctive Presentation in the Context of Jordanian Cases

Amebic liver abscess: An update

A Case of Entamoeba histolytica Liver Abscess in an Immigrant Patient

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