UPLC-MS/MS and Dushman reaction based spectrophotometric method for determination of Ceftazidime, an antibiotic, in medicinal formulation

Antimicrobial agents are essential to protect human and animal health. During the coronavirus disease 2019 pandemic, antimicrobials such as cephalosporins were widely used as prophylactics and to prevent bacterial co-infection.Undoubtedly, the prevalence of antibiotics in the aquatic environment will ultimately affect the degree of resistance against these bacteria in animals and the environmental systems. In order to monitor 16 cephalosporins in the aquatic environment, we developed a new liquid chromatography-tandem mass spectrometry method that functioned simultaneously under positive and negative electrospray ionization switching modes. The chromatographic separation has been implemented using a pentafluorophenyl propyl column kept at 40 • C. The limits of detection and quantitation for the studied cephalosporins ranged from (8 × 10 −4 ) to (7.11 × 10 −2 ) ng/ml and from (2.61 × 10 −3 ) to (2.37 × 10 −1 ) ng/ml, respectively. The percent extraction efficiency (apparent recovery) and relative standard deviations for the analyzed cephalosporins ranged from 61.69% to 167.67% and 2.45% to 13.48%, respectively. The overall findings showed that the effluent from the wastewater treatment plants that receive wastewater from pharmaceutical factories had a higher detected amount of cephalosporins than that of domestic sewage. Moreover, seven cephalosporins, including cefuroxime, ceftazidime, cefradine, cefprozil, cefixime, cefalexin, and cefadroxil (0.68-105.45 ng/L) were determined in the aquatic environment.

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Quantification of 16 cephalosporins in the aquatic environment by liquid chromatography‐tandem mass spectrometry

Kaddah

Al-Dokhmaisy

Mansour

et al. 2022

J of Separation Science

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A three-dimensional hybrid of CdS quantum dots/chitosan/reduced graphene oxide-based sensor for the amperometric detection of ceftazidime

2022

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Covalent organic frameworks derived carbon supported cobalt ultra-small particles: C O and Co-Nx complex sites activated peroxymonosulfate synergistically for efficient degradation of levofloxacin

Cao

Lei

Zhang

et al. 2022

Journal of Cleaner Production

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UPLC-MS/MS and Dushman reaction based spectrophotometric method for determination of Ceftazidime, an antibiotic, in medicinal formulation

Cited by 3 publications

References 22 publications

Quantification of 16 cephalosporins in the aquatic environment by liquid chromatography‐tandem mass spectrometry

Quantification of 16 cephalosporins in the aquatic environment by liquid chromatography‐tandem mass spectrometry

A three-dimensional hybrid of CdS quantum dots/chitosan/reduced graphene oxide-based sensor for the amperometric detection of ceftazidime

Covalent organic frameworks derived carbon supported cobalt ultra-small particles: C O and Co-Nx complex sites activated peroxymonosulfate synergistically for efficient degradation of levofloxacin

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