2007
DOI: 10.1111/j.1365-2036.2007.03458.x
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Upper gastrointestinal bleeding and the changing use of COX‐2 non‐steroidal anti‐inflammatory drugs and low‐dose aspirin

Abstract: SUMMARY BackgroundRofecoxib was withdrawn in 2004.

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Cited by 33 publications
(48 citation statements)
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“…Despite the numerous studies describing the gastrointestinal (GI) side effects of NSAIDs, they continue to be the drugs that are most commonly used in the vast majority of painful conditions. NSAIDs are generally well tolerated, but patients and clinicians continue to face the significant challenge of their serious GI complications, including bleeding, perforation, and occasionally death [1]. In almost all volunteers challenged with aspirin, mild haemorrhagic gastropathy involving the proximal or entire stomach develops within 24 h. The bleeding associated with this acute damage is minimal and only rarely clinically apparent.…”
Section: Introductionmentioning
confidence: 98%
“…Despite the numerous studies describing the gastrointestinal (GI) side effects of NSAIDs, they continue to be the drugs that are most commonly used in the vast majority of painful conditions. NSAIDs are generally well tolerated, but patients and clinicians continue to face the significant challenge of their serious GI complications, including bleeding, perforation, and occasionally death [1]. In almost all volunteers challenged with aspirin, mild haemorrhagic gastropathy involving the proximal or entire stomach develops within 24 h. The bleeding associated with this acute damage is minimal and only rarely clinically apparent.…”
Section: Introductionmentioning
confidence: 98%
“…[8][9][10][11][12][13][14][15][16][17] Indeed, peptic ulcers have been shown to occur among patients with increased GI risk taking ASA daily, within the dose range of 75-100 mg daily. [18] In turn, peptic ulcers may lead to serious complications, including upper GI bleeding, perforation, and gastric outlet obstruction.…”
Section: Introductionmentioning
confidence: 99%
“…Recent evidence also suggests that the increasing incidence of upper gastrointestinal bleeding could be accounted for by the widespread and increasing use of low-dose ASA 9,46,47 . Over the last 10 years, for example, the incidence of upper gastrointestinal bleeding attributed to low-dose ASA has increased 3-fold in south-west Scotland 47 .…”
Section: Clinical Evidence Of Low-dose Asa-induced Gastroduodenal Toxmentioning
confidence: 96%
“…Over the last 10 years, for example, the incidence of upper gastrointestinal bleeding attributed to low-dose ASA has increased 3-fold in south-west Scotland 47 . Additionally, a number of patientrelated risk factors increase the risk of upper gastrointestinal complications among patients receiving low-dose ASA.…”
Section: Clinical Evidence Of Low-dose Asa-induced Gastroduodenal Toxmentioning
confidence: 99%