Upper Gastrointestinal Disease Influences the Occurrence of Inflammatory Bowel Disease

Sonnenberg, Amnon; Turner, Kevin; Genta, Robert M.

doi:10.1007/s10620-019-05972-1

Cited by 10 publications

(5 citation statements)

References 15 publications

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“…Much like H pylori, the occurrence GERD, Barrett's oesophagus, and fundic gland hyperplasia were negatively associated with the occurrence of ulcerative colitis, Crohn's disease and microscopic colitis, which leads one to believe that prolonged reduction in acid secretion represents the common denominator that underlies all these inverse associations. 117 It is unlikely that some simple or systemic bias caused these negative associations. First of all, on both sides of the inverse relationship, multiple entities show the same trend.…”

Section: H Pylori Effects On Ibd and Microscopic Colitismentioning

confidence: 99%

Epidemiology of Helicobacter pylori

Sonnenberg

2022

Aliment Pharmacol Ther

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Section: H Pylori Effects On Ibd and Microscopic Colitismentioning

confidence: 99%

Epidemiology of Helicobacter pylori

Sonnenberg

2022

Aliment Pharmacol Ther

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“…In addition, Frost et al analyzed fecal microbiota in 212 H. pylori positive patients and controls, and found H. pylori related to increased fecal microbes diversity [18]. Other studies [19,20] including Sonnenberg et al, who studied biopsies from 302,061 upper and lower endoscopy patients (13,943 IBD), found that weakened gastric acid barrier may protect against IBD development [19]. Therefore, H. pylori may regulate lower digestive tract microbiota through the change of gastric acid secretion [21] and relate to the incidence of IBD.…”

Section: Plos Onementioning

confidence: 99%

The prevalence of Helicobacter pylori infection in inflammatory bowel disease in China: A case-control study

Ding

Wang

et al. 2021

PLoS ONE

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Background & aims Helicobacter pylori (H. pylori) infection remains high in China though the incidence of inflammatory bowel disease (IBD) has increased. Our aim was to investigate the relationship between the prevalence of H. pylori and inflammatory bowel disease. Methods Hospitalized IBD patients including Crohn’s disease (CD) and ulcerative colitis (UC) who had tested H. pylori antibody were enrolled. Controls were chose from age- and sex- matched healthy physical examination people who had H. pylori antibody test in a 1:2 fashion (IBD patients:controls). IBD medical history was recorded. All patients were typed by the Montreal classification. Mayo Clinic score and the Harvey-Bradshaw Severity Index were used to evaluate their disease activity. Patients and controls that had H. pylori eradication therapy before were excluded. Results Two hundred and sixty IBD patients including 213 CD patients and 47 UC patients, and 520 controls were involved in this study. The prevalence of H. pylori infection in IBD patients (9.6%, 25/260) and IBD newly diagnosed patients (12.1%, 8/66), as well as CD patients (8.9%, 19/213) including CD newly diagnosed patients (10.6%, 5/47) and UC patients (12.8%, 6/47) was significantly lower than controls (29.8%, 155/520) (p = 2.796*10−10, 0.007, 5.723*10−9, 0.016, 0.014), while there was no statistically difference between UC newly diagnosed patients and the controls, and IBD patients with different disease type, disease activity and treatment history. Conclusions H. pylori infection had a negative association with IBD, especially CD.

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“…Controversial studies exist in the literature regarding the association between CD and HP gastritis. Some studies reported a low frequency of CD as well as inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis in patients infected with HP [16][17][18]. Fujimori, in his editorial about this issue, suggests that this association might be caused by complex immunological relationships and host immune responses [19].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study

Issever,

Kuloglu,

Sengul

et al. 2023

Cureus

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Aims and objectivesDistal gastrectomy was a widely used therapeutic option for peptic ulcer and gastroesophageal reflux disease until quite recently. The consequences of anatomical and physiological changes following surgery in the gastric mucosa have been the object of interest for the scientist. In this study, we aimed to determine whether Helicobacter pylori (HP) infection and celiac disease were more common in patients with a history of distal gastrectomy. Materials and methodsThis is an observational retrospective study conducted at Giresun University Faculty of Medicine. The medical files of 35 patients with dyspepsia who had a history of distal gastrectomy for benign etiologies (antrectomy group) and 50 patients with dyspepsia (control group) were retrospectively analyzed. ResultsThere were more males and older patients in the antrectomy group. Concerning the lab parameters, platelets, lymphocyte, and albumin levels were significantly lower, and urea, creatinine, anti-Endomisium Ig A (anti-EMA), and anti-tissue transglutaminase IgA (anti-tTGA) antibody positivity were significantly higher in the antrectomy group. Gastric biopsy results revealed a higher positivity of HP, atrophy, neutrophil, and lymphocytes in the antrectomy group. Correlation analysis revealed an inverse correlation between albumin and anti-EMA/atrophy positivity whereas a positive correlation between anti-EMA and HP/atrophy positivity. ConclusionsHP infection and coeliac disease (CD) could be the problems that distal gastrectomy patients with dyspepsia can face during their follow-up. Concerning the pre-malignant potential of HP, its screening and eradication should be performed to prevent the malignant transformation of the remnant gastric tissue.

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Upper Gastrointestinal Disease Influences the Occurrence of Inflammatory Bowel Disease

Cited by 10 publications

References 15 publications

Epidemiology of Helicobacter pylori

Epidemiology of Helicobacter pylori

The prevalence of Helicobacter pylori infection in inflammatory bowel disease in China: A case-control study

Helicobacter Pylori and Celiac Disease Antibody Positivity Have a Higher Prevalence in Patients With Distal Gastrectomy: A Cross-Sectional Retrospective Study

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