Upper Limb Motor Skills Performance Evaluation Based on Point-and-Click Cursor Trajectory Analysis: Application in Early Multiple Sclerosis Detection

Papatheodorou, Nikolaos; Pino, Alexandros; Constantinides, Vasilios C.; Andreadou, Elisabeth; Papageorgiou, Charalabos

doi:10.1109/access.2019.2901926

Cited by 7 publications

(5 citation statements)

References 61 publications

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“…В ходе исследования были получены данные о потенциальной возможности использования алгоритмов, предложенных A. Pino и соавт. [21,22], при разработке программного обеспечения для оценки координации руки у пациентов с РС в российской популяции. По результатам проведенного тестирования установлено, что пациенты с РС хуже справляются с предложенными тестами на координацию.…”

Section: результатыunclassified

“…В качестве метода диагностики нарушения функции верхней конечности была разработана оригинальная компьютерная программа (кинетическая система), в основу которой положены алгоритмы A. Pino и соавт. [21]; алгоритмы представлены в открытом доступе (IDEA 2D) [22]. Программный код реализован авторами настоящего исследования самостоятельно на языке Python, опираясь на описание математической модели оригинального исследования.…”

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Evaluation of the upper extremity motor skills with a computer kinetic system in multiple sclerosis patients

Shumakov

Leshonkov

Vekhina

et al. 2023

Almanac of Clinical Medicine

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Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating neurodegenerative disorder with multiple lesions in the central nervous system. Motor abnormalities are considered to be a major cause of permanent occupational, social and daily disability of MS patients. However, due to serious limitations of existing methods for assessment of upper limb functioning, evaluation of coordinator and motor abnormalities in the upper extremities in clinical practice is difficult. Aim: To evaluate the efficacy of a computer kinetic method in the diagnosis of fine motor abnormalities of upper limbs in MS patients at early stage of the disease, when motor abnormalities in the upper limbs are not yet obvious. Materials and methods: The main study group included 42 patients with confirmed MS, who consented for testing and met the inclusion criteria (among them, absence of obvious motor and coordinator abnormalities in the arms). The mean age of the patients was 36 [29; 44] years. The control group included 31 healthy subjects with a mean age of 28 [21; 37] years. All the patients were assessed with an original computer kinetic system, including a two-minute test, when the patient had to follow a moving object on the screen with a computer mouse. Every test series resulted in 13 final characteristics. Results: The test of the dominant hand showed that compared to the control group, the MS patients without clinical motor abnormalities in the upper extremities spend 20% more time to move to the aim object (p 0.001), have a 18% lower output motor performance (p 0.001), make by 54% more recurrent returns to the aim object (p = 0.012), by 7% more crosses of the ideal trajectory of moving to the aim (p = 0.036), by 32% more deviations from the ideal trajectory of moving along the x axis and by 52% more along the y axis (p 0.001 for both comparisons), as well as they have a 12% lower mean rate of the movements during the computer test (p 0.001) and by 12% more rate picks (p = 0.003). Conclusion: Patients with confirmed MS, low degree of disability and absence of any clinically confirmed motor abnormalities in the upper limbs do have subclinical signs of motor abnormalities in the arms that can be identified by computer kinetic system.

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Section: результатыunclassified

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Evaluation of the upper extremity motor skills with a computer kinetic system in multiple sclerosis patients

Shumakov

Leshonkov

Vekhina

et al. 2023

Almanac of Clinical Medicine

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“…MDC represents the number of direction changes within the axis of the detected sub-paths during drag movements. More recently, these measures have been shown successful in differentiating between groups with and without motor impairment Mertens et al, 2012;Montague et al, 2014;Papatheodorou et al, 2019).…”

Section: Data Preparation Maze Performance and Movement Metricsmentioning

confidence: 99%

Development and Evaluation of Maze-Like Puzzle Games to Assess Cognitive and Motor Function in Aging and Neurodegenerative Diseases

Nef

Chesham

Schütz

et al. 2020

Front. Aging Neurosci.

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There is currently a need for engaging, user-friendly, and repeatable tasks for assessment of cognitive and motor function in aging and neurodegenerative diseases. This study evaluated the feasibility of a maze-like Numberlink puzzle game in assessing differences in game-based measures of cognition and motor function due to age and neurodegenerative diseases. Fifty-five participants, including young (18-31 years, n = 18), older (64-79 years, n = 14), and oldest adults (86-98 years, n = 14), and patients with Parkinson's (59-76 years, n = 4) and Huntington's disease (HD; 35-66 years, n = 5) played different difficulty levels of the Numberlink puzzle game and completed usability questionnaires and tests for psychomotor, attentional, visuospatial, and constructional and executive function. Analyses of Numberlink game-based cognitive (solving time and errors) and motor [mean velocity and movement direction changes (MDC)] performance metrics revealed statistically significant differences between age groups and between patients with HD and older adults. However, patients with Parkinson's disease (PD) did not differ from older adults. Correlational analyses showed significant associations between game-based performance and movement metrics and performance on neuropsychological tests for psychomotor, attentional, visuospatial, and constructional and executive function. Furthermore, varying characteristics of the Numberlink puzzle game succeeded in creating graded difficulty levels. Findings from this study support recent suggestions that data from a maze-like puzzle game provide potential "digital biomarkers" to assess changes in psychomotor, visuoconstructional, and executive function related to aging and neurodegeneration. In particular, game-based movement measures from the maze-like puzzle Numberlink games are promising as a tool to monitor the progression of motor impairment in neurodegenerative diseases. Further studies are needed to more comprehensively establish the cognitive validity and test-retest reliability of using Numberlink puzzles as a valid cognitive assessment tool.

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“…Nonetheless, research on novel BCI solutions for target populations has been limited to laboratory settings (Fager et al, 2012;Wolpaw and Wolpaw, 2012;Guy et al, 2018) and able-bodied adults (Pires et al, 2011;Oken et al, 2018). A modest subset of BCI studies has recruited adults with disabilities, including: amyotrophic lateral sclerosis (Nijboer et al, 2008;Huggins et al, 2011;Oken et al, 2014); multiple sclerosis (Papatheodorou et al, 2019); brainstem stroke (Sellers et al, 2014); muscular dystrophy (Zickler et al, 2011); acquired brain injury (Huang et al, 2019) and cerebral palsy (CP) (Taherian et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Brain-Computer Interfaces for Children With Complex Communication Needs and Limited Mobility: A Systematic Review

Orlandi

House

Karlsson

et al. 2021

Front. Hum. Neurosci.

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Brain-computer interfaces (BCIs) represent a new frontier in the effort to maximize the ability of individuals with profound motor impairments to interact and communicate. While much literature points to BCIs' promise as an alternative access pathway, there have historically been few applications involving children and young adults with severe physical disabilities. As research is emerging in this sphere, this article aims to evaluate the current state of translating BCIs to the pediatric population. A systematic review was conducted using the Scopus, PubMed, and Ovid Medline databases. Studies of children and adolescents that reported BCI performance published in English in peer-reviewed journals between 2008 and May 2020 were included. Twelve publications were identified, providing strong evidence for continued research in pediatric BCIs. Research evidence was generally at multiple case study or exploratory study level, with modest sample sizes. Seven studies focused on BCIs for communication and five on mobility. Articles were categorized and grouped based on type of measurement (i.e., non-invasive and invasive), and the type of brain signal (i.e., sensory evoked potentials or movement-related potentials). Strengths and limitations of studies were identified and used to provide requirements for clinical translation of pediatric BCIs. This systematic review presents the state-of-the-art of pediatric BCIs focused on developing advanced technology to support children and youth with communication disabilities or limited manual ability. Despite a few research studies addressing the application of BCIs for communication and mobility in children, results are encouraging and future works should focus on customizable pediatric access technologies based on brain activity.

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Upper Limb Motor Skills Performance Evaluation Based on Point-and-Click Cursor Trajectory Analysis: Application in Early Multiple Sclerosis Detection

Cited by 7 publications

References 61 publications

Evaluation of the upper extremity motor skills with a computer kinetic system in multiple sclerosis patients

Evaluation of the upper extremity motor skills with a computer kinetic system in multiple sclerosis patients

Development and Evaluation of Maze-Like Puzzle Games to Assess Cognitive and Motor Function in Aging and Neurodegenerative Diseases

Brain-Computer Interfaces for Children With Complex Communication Needs and Limited Mobility: A Systematic Review

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