Upregulation of CDGSH iron sulfur domain 2 attenuates cerebral ischemia/reperfusion injury

Hu, Miao; Huang, Jie; Chen, Lei; Sun, Xiao‐Rong; Yao, Zi-Meng; Tong, Xuhui; Jin, Wenjing; Zhang, Yuxin; Dong, Shuying

doi:10.4103/1673-5374.355766

Cited by 12 publications

(1 citation statement)

References 67 publications

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“…Some flavonoids may also protect against metabolic dysregulation in neurodegenerative processes by inhibiting LDHA activity in the brain ( Zhang et al, 2015a ). Additionally, flavonoids have been reported to alleviate brain damage caused by ischemia and reperfusion through LDH inhibition and anti-oxidant effects ( Dong et al, 2013 ). The flavonoid oroxylin A reduces LDH expression ( Sajeev et al, 2022 ) and shows potential for preventing and treating neurological diseases ( Lu et al, 2016 ).…”

Section: Natural Compounds As Ldh Inhibitors: Polyphenols Alkaloids T...mentioning

confidence: 99%

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Han,

Lee,

Park

et al. 2023

Front. Pharmacol.

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Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and present in various cells throughout the body. Its diverse physiological functions encompass glycolysis, and its abnormal activity is associated with numerous diseases. Targeting LDH has emerged as a vital approach in drug discovery, leading to the identification of LDH inhibitors among natural compounds, such as polyphenols, alkaloids, and terpenoids. These compounds demonstrate therapeutic potential against LDH-related diseases, including anti-cancer effects. However, challenges concerning limited bioavailability, poor solubility, and potential toxicity must be addressed. Combining natural compounds with LDH inhibitors has led to promising outcomes in preclinical studies. This review highlights the promise of natural compounds as LDH inhibitors for treating cancer, cardiovascular, and neurodegenerative diseases.

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Section: Natural Compounds As Ldh Inhibitors: Polyphenols Alkaloids T...mentioning

confidence: 99%

Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases

Han,

Lee,

Park

et al. 2023

Front. Pharmacol.

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Progress of Ferroptosis in Ischemic Stroke and Therapeutic Targets

Tian,

Li,

Pan

et al. 2024

Cell Mol Neurobiol

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Ferroptosis is an iron-dependent form of programmed cell death (PCD) and ischemic stroke (IS) has been confirmed to be closely related to ferroptosis. The mechanisms of ferroptosis were summarized into three interrelated aspects: iron metabolism, lipid peroxide metabolism, as well as glutathione and amino acid metabolism. What’s more, the causal relationship between ferroptosis and IS has been elucidated by several processes. The disruption of the blood–brain barrier, the release of excitatory amino acids, and the inflammatory response after ischemic stroke all lead to the disorder of iron metabolism and the antioxidant system. Based on these statements, we reviewed the reported effects of compounds and drugs treating IS by modulating key molecules in ferroptosis. Through detailed analysis of the roles of these key molecules, we have also more clearly demonstrated the essential effect of ferroptosis in the occurrence of IS so as to provide new targets and ideas for the therapeutic targets of IS. Graphical Abstract Three abnormal cell metabolism pathways contribute to ferroptosis after ischemic stroke, and many key regulatory compounds in ferroptosis can play important therapeutic roles.

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