Upregulation of long noncoding RNA RP4 exacerbates hypoxia injury in cardiomyocytes through regulating miR-939/Bnip3/Wnt/β-catenin pathway

Rong, Jingfeng; Xu, Jin; Liu, Qian; Wu, Yaoyao; Guo, Huiling; Mu, Ting; Zhou, Hua; Chi, Hao

doi:10.1080/21691401.2019.1640232

Cited by 2 publications

(1 citation statement)

References 30 publications

(36 reference statements)

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“…The function of BNIP3 is similar to that of PTP4A1, which includes the inhibition of cancer aggression. PTP4A1 can be modulated by the lncRNAs HULC and RP4 in response to cellular injury [ 29 , 30 ]. These findings suggest that RP11-317-J19.1, PTP4A1 , and BNIP3 may play crucial roles in restraining cancer aggressiveness; thus, they serve as strong predictors of breast cancer bone metastasis.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer

Teng

Yang

Huang

et al. 2021

Aging

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The molecular mechanism of bone metastasis in breast cancer is largely unknown. Herein, we aimed to identify the key genes and long non-coding RNAs (lncRNAs) related to the bone metastasis of breast cancer using a bioinformatics approach. We screened differentially expressed genes and lncRNAs between normal breast and breast cancer bone metastasis samples using the GSE66206 dataset from the Gene Expression Omnibus. We also constructed a differentially expressed lncRNA-mRNA interaction network and analyzed the node degrees to identify the driving genes. After finding potential pathogenic modules of breast cancer bone metastasis, we identified breast cancer bone metastasis-related modules and functional enrichment analysis of the genes and lncRNAs in the modules. Based on the above analysis, we constructed a differentially expressed lncRNA-mRNA network related to bone metastasis in breast cancer and identified core driver genes, including BNIP3 and the lncRNA RP11-317-J19.1. The role of core driver genes and lncRNAs in the network implies their biological functions in regulating bone development and remodeling. Thus, targeting the core driver genes and lncRNAs in the network may be a promising therapeutic strategy to manage bone metastasis.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer

Teng

Yang

Huang

et al. 2021

Aging

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MiR-939-5p suppresses PM_2.5-induced endothelial injury via targeting HIF-1α in HAECs

et al. 2021

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Upregulation of long noncoding RNA RP4 exacerbates hypoxia injury in cardiomyocytes through regulating miR-939/Bnip3/Wnt/β-catenin pathway

Abstract: Chi (2019) Upregulation of long noncoding RNA RP4 exacerbates hypoxia injury in cardiomyocytes through regulating miR-939/Bnip3/Wnt/β-catenin pathway, Artificial Cells,

Cited by 2 publications

References 30 publications

Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer

Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer

MiR-939-5p suppresses PM_2.5-induced endothelial injury via targeting HIF-1α in HAECs

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Upregulation of long noncoding RNA RP4 exacerbates hypoxia injury in cardiomyocytes through regulating miR-939/Bnip3/Wnt/β-catenin pathway

Abstract: Chi (2019) Upregulation of long noncoding RNA RP4 exacerbates hypoxia injury in cardiomyocytes through regulating miR-939/Bnip3/Wnt/β-catenin pathway, Artificial Cells,

Cited by 2 publications

References 30 publications

Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer

Bioinformatics analysis for the identification of key genes and long non-coding RNAs related to bone metastasis in breast cancer

MiR-939-5p suppresses PM2.5-induced endothelial injury via targeting HIF-1α in HAECs

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MiR-939-5p suppresses PM_2.5-induced endothelial injury via targeting HIF-1α in HAECs