RÉSUMÉ La présente enquête avait pour objectif d'évaluer le niveau de connaissances, les attitudes et pratiques vis-à-vis des précautions standard (PS) parmi le personnel soignant duABSTRACT This survey aims at assessing knowledge, attitudes and practices towards standard precautions (SP) among caregivers at Hassan II University Teaching Hospital in Fes. This is a cross-sectional prospective and evaluative study that covers a two-month period. Data were collected using an anonymous and selfadministered questionnaire. Sampling population was divided into 307 nurses (53.8%), 210 hospital doctors (36.77%) and 57 support staff (9.45%), belonging to other various categories working in different departments. This is a young population since 79.7% are under 30 years old. The results have shown that only 28.72% of health care professionals had received training in SP. Moreover, 87.7% claimed to practice hands' hygiene while moving from one patient to another. In contrast, 75.7% emphasized the need to change gloves each time they work on a new patient. However, individual protection measures were rarely mentioned in several risky situations.