Urapidil au cours de la chirurgie du phéochromocytome: commencer dès la phase préopératoire

Successful laparoscopic operation of bilateral pheochromocytoma in a patient with Beckwith-Wiedemann syndrome

“…Pre-and per-operative urapidil by intravenous perfusion with dosage matched to blood pressure, as has been described for the laparoscopic removal of unilateral pheochromocytomas, 15,16 was used with success in our bilateral intervention. In our patient (Table 1), the sharp increase in plasma cathecholamine levels after pneumoperitoneum and manipulation of each tumor underlines the need for adequate alpha receptor blockade and the clear-cut fall in catecholamine levels following removal of each tumor confirmed the bilateral nature of the disorder.…”

Effects of perioperative α 1 block on haemodynamic control during laparoscopic surgery for phaeochromocytoma

“…7±9 It is of pivotal importance to limit the effects of such release through preoperative preparation of the patient and perioperative use of drugs that block the effects of catecholamines on a 1 receptors. 10 However, there is a risk of severe hypotension after the tumour removal when long acting a 1 blockers are used. Urapidil, a competitive and selective short acting a 1 blocker is also an agonist at central serotoninergic receptors.…”