Urban particulate air pollution linked to dyslipidemia by modification innate immune cells

Association between Air Pollution and Lipid Profiles

“…However, most studies reported that air pollution was associated with adverse changes in 1-3 lipid indexes, and the changes in the others are beneficial or not significant [6,10,[12][13][14][15][16][17][18]20,[22][23][24][25][26][27][28][29][30][31][32][33][34][35]38,48]. A few studies reported that air pollution was associated with adverse changes in all four conventional lipid indexes [19,21,56], such as the study of Wang et al, which showed that a 10 µg/m 3 increase in PM 2.5 concentration was associated with a 0.92% increase in TC, a 2.23% increase in TG, a 3.04% increase in LDL-C, and a 2.03% decrease in HDL-C [19]. In addition, there are also very few studies that have reported the individual beneficial effects of air pollution, such as the study of Mao et al, in which PM 1 and PM 2.5 were associated with the reduction in TG [13,14].…”

“…In addition to the common TG, TC, LDL-C, and HDL-C, the outcome indexes also included apolipoprotein A (ApoA), apolipoprotein B (ApoB), the ratio of ApoA to ApoB, low-density lipoprotein particles (LDL-P), oxidized low-density lipoprotein (ox-LDL), nonhigh-density lipoprotein cholesterol (non-HDL-C), and TC/HDL-C [10,33,56]. ApoA and ApoB are important components of HDL and LDL, respectively.…”