Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth

Park, Sunwha; You, Young Ah; Kim, Young-Han; Kwon, Eunjin; Ansari, AbuZar; Kim, Soo Min; Lee, Ga-In; Hur, Young Min; Jung, Yun Hwa; Kim, Kwangmin; Kim, Young Ju

doi:10.1038/s41598-022-13871-1

Cited by 14 publications

(11 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previous study, we used machine learning with the ratio of relative abundances of L. iners and U. parvum for PTB prediction 27 . We also reported that Ureaplasma and Prevotella colonization with Lactobacillus during pregnancy facilitates FTB 28 . In this study, in the logistic regression analysis, we included the L. iners and U. parvum abundances and the gestational age at sampling as adjusted factors to analyze the risk of PTB.…”

Section: Discussionmentioning

confidence: 54%

“…We then reported the bacterial risk score for PTB prediction based on the ratio of L. iners and Ureaplasma parvum abundances 27 . Recently, we reported that Ureaplasma and Prevotella abundances, along with Lactobacillus abundance, are associated with full-term birth (FTB) 28 . Here, we analyzed the characteristics of the vaginal microbial community during pregnancy in a cohort of Korean women and determined whether the characteristics of a particular community were associated with the risk of PTB in a case–control study.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Transition in vaginal Lactobacillus species during pregnancy and prediction of preterm birth in Korean women

You

Park

Kim

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

The predominance of vaginal Lactobacillus species, specifically L. crispatus, is important for pregnancy maintenance, but varies by race. The composition of the vaginal microbiome can affect susceptibility to adverse pregnancy outcomes. We performed 16S rRNA gene amplicon sequencing on vaginal swabs taken from Korean pregnant women. Here, we report the transition of Lactobacillus spp. in samples of full-term birth (FTB) collected longitudinally in the second and third trimesters of pregnancy in a cohort study (n = 23) and their association with Lactobacillus abundance and preterm birth (PTB) in a case–control study (n = 200). Lactobacillus species, which was dominant in FTB samples including those that received interventions in the second trimester, did not change until 37 weeks of gestation. However, L. crispatus was replaced by other Lactobacillus species after 37 weeks. The PTB risk showed a closer association with the Lactobacillus abundance than with community state type determined by Lactobacillus species. PTB was associated with less than 90% of Lactobacillus abundance and an increase in Ureplasma parvum in the second trimester. Thus, the vaginal microbiome may change in preparation for childbirth in response to multiple intrinsic factors after 37 weeks of gestation. Monitoring the Lactobacillus abundance may help improve the reliability of microbial PTB biomarkers.

show abstract

Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Transition in vaginal Lactobacillus species during pregnancy and prediction of preterm birth in Korean women

You

Park

Kim

et al. 2022

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…Furthermore, we found a relative increase in the abundance of Gardnerella and Ureaplasma in the third trimester compared to the first and second trimesters, but this increase was in accordance with a high Lactobacillus abundance. Gardnerella and Ureaplasma are well-known pathogens associated with adverse pregnancy outcomes [ 55 ]. However, recent microbiome reports [ 7 , 55 ] point out that vaginal colonization with Ureaplasma and Gardnerella during a pregnancy with Lactobacillus abundance seems to be protective against pregnancy complications.…”

Section: Discussionmentioning

confidence: 99%

“…Gardnerella and Ureaplasma are well-known pathogens associated with adverse pregnancy outcomes [ 55 ]. However, recent microbiome reports [ 7 , 55 ] point out that vaginal colonization with Ureaplasma and Gardnerella during a pregnancy with Lactobacillus abundance seems to be protective against pregnancy complications. Park et al, 2022 [ 55 ] demonstrated that Ureaplasma and Lactobacillus coexistence with high Lactobacillus abundance leads to term birth.…”

Section: Discussionmentioning

confidence: 99%

“…However, recent microbiome reports [ 7 , 55 ] point out that vaginal colonization with Ureaplasma and Gardnerella during a pregnancy with Lactobacillus abundance seems to be protective against pregnancy complications. Park et al, 2022 [ 55 ] demonstrated that Ureaplasma and Lactobacillus coexistence with high Lactobacillus abundance leads to term birth. In addition, Park et al, 2022 [ 55 ], Liu et al, 2022 [ 7 ], and DiGuilio, 2015 [ 16 ] reported that preterm birth and premature membrane ruptures are only predictive with low or depleted Lactobacillus abundance in the presence of Ureaplasma and Gardnerella.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Compositional Changes in the Vaginal Bacterial Microbiome of Healthy Pregnant Women across the Three Gestational Trimesters in Ismailia, Egypt

et al. 2023

View full text Add to dashboard Cite

The composition of the vaginal microbiome may lead to adverse pregnancy outcomes. Normal pregnancy is associated with changes in the vaginal bacterial community composition, which tend to be more enriched with one or two Lactobacillus species promoting a healthy vagina and favorable birth outcomes. The aim of the current study was to determine compositional changes in the healthy vaginal microbiome composition during the three trimesters of pregnancy in Ismailia, Egypt using Illumina MiSeq sequencing of the V3–V4 region of the 16S rRNA. The phylum Firmicutes and the genus Lactobacillus dominated across the three trimesters of pregnancy. L. iners was the most abundant species. However, L. coleohominis and L. reuteri represented the least dominant vaginal lactobacilli. Core microbiome analyses showed the Lactobacillus genus and L. iners species to have the highest prevalence in all the samples of our study groups. The phylum Firmicutes was found to be negatively correlated with almost all other vaginal phyla during pregnancy. Likewise, a negative correlation between Lactobacillus and almost all other genera was detected, including significant negative correlations with Dialister and Prevotella. Furthermore, negative correlations of L. iners were detected with almost all other species, including a significant negative correlation with L. helveticus, G. vaginalis, S. anginosus, and S. agalactiae.

show abstract

Oral microbiota in preschoolers with rampant caries: a matched case–control study

Wu,

Li,

Lyu

et al. 2024

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Rampant caries is identified by rapid onset, severe decay affecting multiple surfaces, and early pulp infection. This case–control study was conducted to investigate the disparities in oral microbiota between children affected by rampant caries and their caries-free counterparts. A total of 88 preschool children, with matched distribution of sex and age in both the case and control groups, participated in this study. Children’s oral health–related behaviors were reported by parents, salivary pH levels were assessed using a portable pen-type pH meter, and supragingival dental plaque was analyzed by 16S rRNA gene sequencing. Children with rampant caries exhibited lower salivary pH levels, poorer toothbrushing habits, and more frequent consumption of sugary snacks. Veillonella, enriched in caries-free children, showed a positive correlation with salivary pH levels and a negative correlation with candy consumption. Conversely, Fusobacterium and Neisseria, more abundant in children with rampant caries, positively correlated with the frequency of candy consumption. Furthermore, Streptococcus mutans, Porphyromonas gingivalis, and Bacteroides acidifaciens were identified as potential oral microbiome markers for differentiating preschoolers with rampant caries from their caries-free peers. B. acidifaciens, typically found in the gut, has been rarely reported in the field of oral health. More well-designed cohort studies are recommended to elucidate the mechanisms through which gut microbiota influences rampant caries in pediatric patients and offer insights into effective strategies for caries management in young children. Key points • Lower salivary pH levels in children with rampant caries. • Biomarkers for predicting rampant caries. • Impact of oral health–related behaviors on oral microbiota.

show abstract

Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth

Cited by 14 publications

References 43 publications

Transition in vaginal Lactobacillus species during pregnancy and prediction of preterm birth in Korean women

Transition in vaginal Lactobacillus species during pregnancy and prediction of preterm birth in Korean women

Compositional Changes in the Vaginal Bacterial Microbiome of Healthy Pregnant Women across the Three Gestational Trimesters in Ismailia, Egypt

Oral microbiota in preschoolers with rampant caries: a matched case–control study

Contact Info

Product

Resources

About