Ureteral Involvement Is Associated with Poor Prognosis in Upper Urinary Tract Urothelial Carcinoma Patients Treated by Nephroureterectomy: A Multicenter Database Study

Predictive ability of renal cortex enhancement in dynamic computed tomography for residual renal function after nephroureterectomy: Comparison with 99mTc‐diethylenetriaminopentacetic acid renography and validation study

“…UTUC has an aggressive biology, and previous studies including the present study have reported that one‐third to one‐half of patients have stage T3 or greater disease at the time of surgery . Although RNU with bladder cuff excision is the gold standard for the treatment of localized UTUC, the oncological outcomes for patients with high‐grade or non‐organ‐confined disease remain poor, with 5‐year cancer‐specific survival rates of approximately 50% .…”

“…UTUC has an aggressive biology, and previous studies including the present study have reported that one-third to one-half of patients have stage T3 or greater disease at the time of surgery. [18][19][20] Although RNU with bladder cuff excision is the gold standard for the treatment of localized UTUC, the oncological outcomes for patients with high-grade or non-organ-confined disease remain poor, with 5-year cancer-specific survival rates of approximately 50%. 21,22 It is debatable, however, whether a pre-or postoperative setting would be preferable for the administration of perioperative systemic chemotherapy, under our limited ability to predict tumor stage and renal function decrement caused by the loss of a renal unit.…”

Survival differences of patients with ureteral versus pelvicalyceal tumours: a systematic review and meta-analysis

“…The 14 studies in this meta-analysis included 14,895 participants [13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The baseline characteristics of the included studies are summarised in Table I study ranged from 133 to 3387 (mean 1064, median 623).…”

“…The ureter has a thin layer of surrounding adventitia that contains a plexus of blood and lymphatic vessels. Waseda et al proved that lymphovascular invasion (LVI) is more often observed in ureteral localisation [23], whereas Lee et al emphasised that LVI is a practical prognostic parameter, especially in ureteral tumours [27]. Conversely, tumours located in the renal pelvis are surrounded by renal parenchyma and perihilar adipose tissue, which is a natural barrier that is capable of containing the spread of tumour cells, and provides wider surgical margins and enables easier resection.…”

“…Moreover, Waseda et al suggested that tumours in both locations should be considered as UI independently of tumour stage in the ureter. The author proved that no difference in survival between patients with both regional tumours and patients with tumours located only in the ureter exists [23]. Therefore, patients with tumours in two distinct locations should be taken into account in the analysis of UI instead of the analysis of tumour focality.…”