Uric acid is a key player in salt-induced endothelial dysfunction: the therapeutic role ofStigma maydis(corn silk) extract

Abstract

Hyperuricemia has been implicated in the pathogenesis and complications of cardiovascular diseases with associated elevated oxidant events. There is evidence that excessive salt intake results in cardiometabolic disturbances but the mechanism is elusive. Also, Stigma maydis (corn silk) is noted for its antioxidant properties among other beneficial roles. This study, therefore, aimed to establish the effect of high-salt diet (SD) on uric acid (UA) production and the role of S. maydis in salt-induced phenotypes. Four groups of randomly selected rats (n = 5) were fed with normal rat feed, corn silk extract (500 mg/kg), SD (8%) and corn silk extract plus high-salt feed. After 6 weeks of the experimental procedure, each animal was anesthetized by exposure to chloroform vapor and blood samples collected by cardiac puncture. Data were expressed in means ± SEM and p values <0.05 were accepted as significant. SD resulted in reduced plasma superoxide dismutase (SOD), nitric oxide (NO), and glutathione peroxidase (GPx) but not endothelial nitric oxide synthase. Also, plasma UA and vascular cell adhesion molecule-1 (VCAM-1) increased in the SD group compared with control. However, S. maydis extract in the SD-exposed group increased NO and GPx and not SOD. Also, S. maydis extract attenuated UA and VCAM-1. In conclusion, high-salt intake may initiate deleterious cardiovascular events through UA-dependent mechanism and S. maydis extract has therapeutic potential in high-salt–induced oxidative damage and/or UA-dependent endothelial pathologies.

Individual and combined association analysis of famine exposure and serum uric acid with hypertension in the mid-aged and older adult: a population-based cross-sectional study

“…One of the possible mechanism might be uric acid deposition on the blood vessels walls activates the renin-angiotensin system, suppress the liberate of carbon monoxide, enhance inflammation, and leads to vasoconstriction later [ 62 ]. Another possibility involving oxidative stress and endothelial dysfunction related with high SUA level may contribute to elevated blood pressure [ 65 , 66 ].…”

Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis

“…e keywords "hyperuricemia" and "gout" were entered into the TTD, Drugbank, Dis-GeNET, Genecards, OMIM, and PharmGkb databases to obtain gout-related targets. e numbers of disease-related targets were 20, 66, 258, 2319, 13, and 4, respectively, and after deduplication were 20,38,234,1971,13, and 4, respectively. A total of 2081 targets were obtained.…”

“…Based on the syndrome, different methods, such as the promotion of blood circulation, diuresis, and invigorating the kidney, are adopted [11]. rough syndrome differentiation, effective Chinese medicines for gout treatment have been discovered, such as turmeric [12], corn silk [13], and tuckahoe [14]. Both clinical applications and modern pharmacological research have confirmed the uric acidlowering effect of these herbs.…”

Current State of Research in the Field of Chemical Composition and Pharmacological Effects of Zea Maydis Styli Cum Stigmatis

“…Определение содержания оксида азота, супероксиддисмутазы, глутатионпероксидазы и мочевой кислоты в крови и сосудистых тканях лабораторных животных позволило подтвердить существенные негативные изменения, произошедшие под влиянием повышенного потребления соли. Наряду с этим, авторами исследования отмечено, что, благодаря своим антиоксидантным свойствам, терапевтический потенциал экстракта КСР может быть востребован при окислительном повреждении, вызванном высоким содержанием соли и/или мочевой кислоты [30].…”