Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016–2017)

Abstract

Kidney disease is expected to become the fifth leading cause of premature death globally by 2040. Uric acid level is a risk factor for kidney disease. The current study aims to investigate the association between uric acid levels and kidney function in the Korean population. The data of 11,042 participants of the 2016–2017 Korea National Health and Nutrition Examination Survey were analysed. The estimated glomerular filtration rate was calculated using the modification of diet in renal disease formula for Koreans. For each sex, uric acid levels were divided into five subsequent categories of increasing levels (Q1, Q2, Q3, Q4, and hyperuricemia). The association between uric acid level and kidney function was investigated using multiple logistic regression. The results showed that the higher the uric acid levels, the greater the odds of reduced kidney function in both sexes. In men, the adjusted odds ratios (95% confidence intervals) for reduced eGFR comparing the hyperuricemia group to the lowest serum uric acid quartile was 5.55 (3.27–9.44), and in women, the odds ratios (95% confidence intervals) was 7.52 (4.39–12.87). Normal weight or underweight in men and overweight in women, as well as diabetes mellitus, hypertension, and physical inactivity were highly associated with reduced kidney function. Our study revealed a dose–response relationship between uric acid levels and kidney function. Therefore, high uric acid level should be considered as a factor that is potentially related to kidney dysfunction in the Korean population.

The state of carotid artery wall in hypertensive patients with gout based on the study of inflammatory markers

“…Many studies have shown an association between IMC and high importance of major vascular risk factors for circulatory disorders: dyslipidemia and hypertension. The IMC thickness determines the individual severity of cardiovascular diseases [1,2].…”

“…Hyperuricemia, which in some cases leads to the development of gout, is involved in the pathogenesis of hypertension and atherosclerosis [1]. Epidemiological studies revealed the relationship between hyperuricemia and atherosclerotic vascular disease, and serum uric acid (UA) levels, making it possible to predict cardiovascular events and mortality in women and men [2].…”

Age at onset of alcohol consumption and its association with alcohol misuse in adulthood

“…(Continues) males and females, the results showed a linear increase as the age at first use of alcohol decreased. In male group, 15 or under OR was 2.50, 95% CI (1.97-3.17),16-18 OR 1.82, 95% CI (1.46-2.27), 19-23 OR 1.29, 95% CI (1.04-1.60), and putting those who first started drinking alcohol after they became age 24. In female group, 15 or under group OR was 1.66, 95% CI (1.18-2.33), 16-18 OR 1.61, 95% CI (1.23-2.11), 19-23 OR 1.04, 95% CI (0.81-1.…”

“…Due to the feature of cross-sectional study, overlapping individuals by year were not removed, but they were regarded as another individual study participant. The data from these surveys are used to monitor and estimate the prevalence of chronic diseases and citizens'health in the South Korean population 16,17.…”

Medical Students’ Perspective and Knowledge of Asymptomatic Hyperuricemia and Gout Management: A Cross-Sectional Study

“…Although uric acid is an endogenous antioxidant, studies link high serum uric acid levels with a number of conditions, including hypertension and cardiovascular disease, as well as metabolic syndrome and diabetes [ 3 , 4 , 5 , 6 ]. A large Korean study on more than 11,000 participants found a dose–response relationship between uric acid levels and decreased kidney function in both men and women [ 7 ]. The causal relationship and mechanisms connecting gout, hyperuricemia, and various comorbidities are complex, and not fully understood, with contradicting reports and studies [ 8 , 9 , 10 ].…”