Uric acid levels in patients on antituberculosis drugs in the southwest Region of Cameroon

Pokam, Benjamin D. Thumamo; Eteneneng, Enoh Jude; Eyo, Aniekan-Augusta Okon; Umoh, Nse O.; Guemdjom, Prisca Wabo

doi:10.4103/ijmy.ijmy_161_17

Cited by 7 publications

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“…Therefore, weak correlations were found between INH and RMP and INH and EMB in our work. A large number of previous studies have shown that anti-TB drugs can affect UA metabolism in humans, which could result in Frontiers in Pharmacology frontiersin.org elevated blood UA (Louthrenoo et al, 2015;Thumamo Pokam et al, 2018;Ha et al, 2019). We also found that UA was an independent influencing factor of the PZA concentration.…”

Section: Discussionmentioning

confidence: 99%

Correlations among the plasma concentrations of first-line anti-tuberculosis drugs and the physiological parameters influencing concentrations

Cheng,

Luo,

Guo

et al. 2023

Front. Pharmacol.

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Background: The plasma concentrations of the four most commonly used first-line anti-tuberculosis (TB) drugs, isoniazid (INH), rifampicin (RMP), ethambutol (EMB), and pyrazinamide (PZA), are often not within the therapeutic range. Insufficient drug exposure could lead to drug resistance and treatment failure, while excessive drug levels may lead to adverse reactions. The purpose of this study was to identify the physiological parameters influencing anti-TB drug concentrations.Methods: A retrospective cohort study was conducted. The 2-h plasma concentrations of the four drugs were measured by using the high-performance liquid chromatography-tandem mass spectrometry method.Results: A total of 317 patients were included in the study. The proportions of patients with INH, RMP, EMB, and PZA concentrations within the therapeutic range were 24.3%, 31.5%, 27.8%, and 18.6%, respectively. There were positive associations between the concentrations of INH and PZA and RMP and EMB, but negative associations were observed between the concentrations of INH and RMP, INH and EMB, RMP and PZA, and EMB and PZA. In the multivariate analysis, the influencing factors of the INH concentration were the PZA concentration, total bile acid (TBA), serum potassium, dose, direct bilirubin, prealbumin (PA), and albumin; those of the RMP concentration were PZA and EMB concentrations, weight, α-l-fucosidase (AFU), drinking, and dose; those of the EMB concentration were the RMP and PZA concentrations, creatinine, TBA and indirect bilirubin; and those of the PZA concentration were INH, RMP and EMB concentrations, sex, weight, uric acid and drinking.Conclusion: The complex correlations between the concentrations of the four first-line anti-TB drugs lead to a major challenge in dose adjustment to maintain all drugs within the therapeutic window. Levels of TBA, PA, AFU, and serum potassium should also be considered when adjusting the dose of the four drugs.

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Section: Discussionmentioning

confidence: 99%

Correlations among the plasma concentrations of first-line anti-tuberculosis drugs and the physiological parameters influencing concentrations

Cheng,

Luo,

Guo

et al. 2023

Front. Pharmacol.

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Hyperthyroidism is an important risk factor for incident gout particularly in younger age groups and males

Tao,

Xu,

Fang

2023

Rheumatol Int

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Drug resistance in drug-resistant tuberculosis patients with and without diabetes mellitus: a comparative analysis

Cai,

Xu,

et al. 2024

BMC Infect Dis

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Uric acid levels in patients on antituberculosis drugs in the southwest Region of Cameroon

Abstract: Hyperuricemia is associated with ATDs, with treatment duration being a significant factor. The disorder should be closely monitored, especially during the intensive phase of treatment.

Cited by 7 publications

References 0 publications

Correlations among the plasma concentrations of first-line anti-tuberculosis drugs and the physiological parameters influencing concentrations

Correlations among the plasma concentrations of first-line anti-tuberculosis drugs and the physiological parameters influencing concentrations

Hyperthyroidism is an important risk factor for incident gout particularly in younger age groups and males

Drug resistance in drug-resistant tuberculosis patients with and without diabetes mellitus: a comparative analysis

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