Uridine 5'diphospho‐glucuronosyltransferase 1A expression as an independent prognosticator in urothelial carcinoma of the upper urinary tract

Izumi, Kiyotaka; Inoue, Satoshi; Ide, Hiroki; Fujita, Kazutoshi; Mizushima, Taichi; Jiang, Guiyang; Yamaguchi, Seiji; Fushimi, Hiroaki; Nonomura, Norio; Miyamoto, Hiroshi

doi:10.1111/iju.13528

Cited by 3 publications

(4 citation statements)

References 28 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In SVHUC cells subsequently exposed to MCA, GATA3 knockdown resulted in the promotion of neoplastic transformation, along with down-regulation of the expression of tumor suppressor genes (e.g., p53, p21, PTEN) and up-regulation of that of oncogenes (e.g., c-myc, cyclins, FGFR3) [33], suggesting its function as a suppressor of urothelial tumor. Immunohistochemical studies in bladder [65] or UUT [62] specimens further showed significant down-regulation of UGT1A expression in tumors, compared with non-neoplastic urothelial tissues.…”

Section: Gata3mentioning

confidence: 94%

“…Correspondingly to a potential difference in the susceptibility to bladder carcinogens between men and women, the expression levels of mouse Ugt1a subtypes were shown to be considerably higher in the bladders from females than in those from males [60]. In immunohistochemical studies in bladder [61] or UUT [62] specimens, UGT1A expression was down-regulated in tumors, compared with non-neoplastic urothelial tissues, as well as in high-grade and/or muscle-invasive tumors, compared with low-grade and/or non-muscle-invasive tumors, and its positivity was associated with better patient outcomes.…”

Section: Udp-glucuronosyltransferases (Ugts)mentioning

confidence: 97%

See 1 more Smart Citation

The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis

Ide

Miyamoto

2020

Cancers

Self Cite

View full text Add to dashboard Cite

Preclinical and/or clinical evidence has indicated a potential role of steroid hormone-mediated signaling pathways in the development of various neoplastic diseases, while precise mechanisms for the functions of specific receptors remain poorly understood. Specifically, in urothelial cancer where sex-related differences particularly in its incidence are noted, activation of sex hormone receptors, such as androgen receptor and estrogen receptor-β, has been associated with the induction of tumor development. More recently, glucocorticoid receptor has been implied to function as a suppressor of urothelial tumorigenesis. This article summarizes and discusses available data suggesting that steroid hormone receptors, including androgen receptor, estrogen receptor-α, estrogen receptor-β, glucocorticoid receptor, progesterone receptor and vitamin D receptor, as well as their related signals, contribute to modulating urothelial tumorigenesis.

show abstract

Section: Gata3mentioning

confidence: 94%

Section: Udp-glucuronosyltransferases (Ugts)mentioning

confidence: 97%

The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis

Ide

Miyamoto

2020

Cancers

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, UGT1A expression was positively and negatively correlated with the levels of ERα and ERβ, respectively, but not those of AR. In a recent immunohistochemical study in UUT urothelial carcinoma tissues, the expression of UGT1A was down-regulated in tumors, compared with non-neoplastic urothelial tissues, and in MI tumors, compared with NMI tumors ( 119 ). Furthermore, UGT1A positivity in M0 tumors was found to be an independent predictor for better cancer-specific survival (HR=0.28; P=0.018).…”

Section: Molecules Whose Expression Is Modulated Via Steroid Hormone Receptor Signalsmentioning

confidence: 95%

The prognostic role of steroid hormone receptor signaling pathways in urothelial carcinoma

Nagata¹,

Miyamoto²

2020

Transl Cancer Res TCR

Self Cite

View full text Add to dashboard Cite

Emerging preclinical or clinical evidence suggests a vital role of nuclear receptor-mediated signals in modulating urothelial carcinogenesis and cancer growth. These include, but are not limited to, androgen receptor, estrogen receptors, glucocorticoid receptor, progesterone receptor, vitamin D receptor, retinoid receptors, and peroxisome proliferator-activated receptors, as well as orphan receptors. In particular, immunohistochemical studies in surgical specimens have demonstrated that increased or decreased expression of steroid hormone receptors, as well as alterations of their upstream or downstream signaling pathways, is often associated with oncologic outcomes in patients with bladder or upper urinary tract cancer. This review article summarizes and discusses available data indicating that steroid hormone receptors and related signals serve as biomarkers for urothelial tumors which further predict their recurrence and/or progression.

show abstract

“…89 It is an important enzyme of glucuronidation (detoxification mechanism of the body), responsible for the biotransformation of carcinogens that enter into the body through diet or as pollutants from the air. 90 In the bladder, acidic urine is responsible for the hydrolysis of glucuronide-carcinogen to release ultimate carcinogens. 91, 92 QR plays a pivotal role in the detoxification process by reducing electrophilic quinones.…”

Section: Anticarcinogenic Mechanism Of Essential Oilmentioning

confidence: 99%

Exploring the Molecular Mechanisms and Therapeutic Potentials of Essential Oils: A Systems Biology Approach

Kashyap

2024

Future Integr Med

View full text Add to dashboard Cite

Biological activities of essential oilsRecent studies on essential oils have highlighted their diverse biological activities, including antimicrobial, antiviral, antihelminthic, antioxidant, antiulcer, anti-inflammatory, insecticidal, larvicidal, and immunomodulatory effects. Essential oils find multifaceted applications in the food, perfume, herbal, and cosmetic industries. In the food industry, they are used for flavoring and preservation, while their aromatic properties are exploited in the cosmetic industry as perfumery components. 8, 9 The various ways that essential oils work through biological networks to exert their effects and their potential mechanisms of action are described below. (Figs. 1 and 2). Antioxidative activities of essential oilsThe excess of free radicals is responsible for the oxidation process.

show abstract

Uridine 5'diphospho‐glucuronosyltransferase 1A expression as an independent prognosticator in urothelial carcinoma of the upper urinary tract

Cited by 3 publications

References 28 publications

The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis

The Role of Steroid Hormone Receptors in Urothelial Tumorigenesis

The prognostic role of steroid hormone receptor signaling pathways in urothelial carcinoma

Exploring the Molecular Mechanisms and Therapeutic Potentials of Essential Oils: A Systems Biology Approach

Contact Info

Product

Resources

About