Urinary arsenic speciation in subjects with or without restriction from seafood dietary intake

Arsenic in the human food chain, biotransformation and toxicology – Review focusing on seafood arsenic

“…From studies where humans have ingested seafood and the urinary excretion of arsenicals have been measured, no indications exist for formation of iAs from ingested organoarsenicals [46,49,54,85,93,99,100,143,144]. Scarce data from human seafood studies indicate that a repeated intake of seafood does not result in higher excretion of iAs than that ingested [93,107].…”

“…A high proportion of MA in urine may indicate lower methylation capacity. Age, smoking and gender seem to influence the relative distribution of methylated urinary arsenicals [85][86][87].…”

Presence of Arsenic in Commercial Beverages

“…The process is not complete and some inorganic arsenic and MMA remain [13] . The trivalent forms of MMA and DMA are more toxic than their inorganic compounds or their pentavalent forms [14] . The trivalent forms have been shown to inhibit enzymatic reactions [15] and should be considered as a potential factor for the development of various cancers.…”

Application of Organometallic Speciation in Clinical Studies

“…In order to understand whether the ingestion of seafood affects urinary As metabolites, urine samples were collected from study subjects and separated by HPLC, linked online to HG-AAS, to quantify the levels of various species of inorganic As and its metabolites [72].…”