Urinary bisphenol A and plasma hormone concentrations in male workers exposed to bisphenol A diglycidyl ether and mixed organic solvents

Hanaoka, Tomoyuki

doi:10.1136/oem.59.9.625

Cited by 160 publications

(106 citation statements)

References 28 publications

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“…We found only one public report on urinary BPA levels of workers occupationally exposed to BPA 16) . The participants in that study were 42 male workers, whose job task was to spray BPA diglycidyl ether (BADGE) with mixed organic solvents as an epoxy resin hardening agent in a machine plant and two related plants.…”

Section: Discussionmentioning

confidence: 83%

Occupational Exposure Levels of Bisphenol A among Chinese Workers

Miao

et al. 2009

Journal of Occupational Health

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The purpose of this study was to assess ambient Bisphenol A (BPA) levels in workplaces and urine BPA levels of workers. Methods: Workers in epoxy resin and BPA manufacturing factories were recruited. Personal samples for airborne BPA were taken in the workshops and spot urine samples were collected from workers before and after their shifts. The samples were assayed with highperformance liquid chromatography with a fluorescence detector. TWA 8 of airborne PBA in the workplaces and biological BPA burden of the workers were calculated. Correlations between the external and the internal exposure levels were sought. Results: Workers from the factories were occupationally exposed to BPA at median personal airborne levels of 6.67 µg/m 3 (or at the mean of 450 µg/m 3 ). More than 90% of the workers who were occupationally exposed to BPA had detectable BPA levels in their blood samples. The medians of creatinine-adjusted urinary BPA levels were 84.6 µg/g Cr and 111 µg/g Cr pre-and post-shift (means of 4,630 µg/g Cr and 5,400 µg/g Cr), respectively. The urinary BPA concentration post-shift was significantly associated with the urinary BPA level pre-shift and personal airborne BPA levels. Conclusions: It was indicated that workers in epoxy resin and BPA manufacturing factories are occupationally exposed to BPA at high levels. There is an urgent need to create occupational standards and take effective preventive Field Studymeasures to protect workers from the potential adverse effects of BPA. (J Occup Health 2009; 51: 432-436)

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Section: Discussionmentioning

confidence: 83%

Occupational Exposure Levels of Bisphenol A among Chinese Workers

Miao

et al. 2009

Journal of Occupational Health

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“…It has also been shown that BADGE generates BPA endogenously in BADGE-exposed male workers and that their plasma FSH levels decrease as their BPA levels rise. Nonetheless, neither free testosterone nor LH levels are affected in these conditions (Hanaoka et al, 2002). In male partners of pregnant women, urinary BPA levels have been inversely associated only with the free androgen index (FAI: testosterone/SHBG; sex hormone-binding globulin; Mendiola et al, 2010).…”

Section: Inhibin Bmentioning

confidence: 99%

Parallel assessment of the effects of bisphenol A and several of its analogs on the adult human testis

et al. 2017

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WHAT IS KNOWN ALREADY:The few epidemiologic studies performed suggest that bisphenols have potential endocrine disruptive properties, but they did not identify clear and direct patterns of endocrine disruption. STUDY DESIGN, SIZE, DURATION:Adult human testis explants in culture were exposed to BPA and the analogs bisphenol F (BPF), bisphenol S (BPS), bisphenol E (BPE), bisphenol B (BPB), and bisphenol A diglycidyl ether (BADGE) at 10 -9 to 10 -5 M for 24 h or 48h.PARTICIPANTS/MATERIALS, SETTING, METHODS: Human adult testes were obtained from prostate cancer patients who had no hormone therapy, or from multiorgan donors. After ex vivo exposure to the investigated bisphenols, the measured outcomes were related to histopathology (gross morphology and germ cell viability determined by anti-caspase 3 immunohistochemistry), and the levels of testosterone, insulin-like fator 3 and inhibin B were measured using immunoassays. The levels of mRNA encoding key enzymes of bisphenol biotransformation were investigated by quantitative PCR: UGT2B15 UDP (glucuronosyltransferase two family, polypeptide B15), GUSB (glucuronidase beta), SULT1A1 and 3 (sulfotransferase family 1 A member 1 and 3) and STS (steroid sulfatase). MAIN RESULTS AND THE ROLE OF CHANCE: A significant dose-dependent inhibition wasfound between testosterone levels measured in the culture medium and concentrations of BPA The active concentrations of BPA and BPA-A used in the study were higher than those found in human biological fluids. WIDER IMPLICATIONS OF THE FINDINGS:Under our experimental conditions, direct exposure to BPA or BPA-A can result in endocrine disturbance in the adult human testis.

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“…(European-Union, 2003). One study measured total urinary bisphenol A in Japanese workers who sprayed an epoxy compound (Hanaoka et al, 2002). …”

Section: Summary Of Human Exposurementioning

confidence: 99%

“…Hanaoka et al (2002), supported by the Japanese Ministry of Health and Welfare and Ministry of Education, Science, Sports, and Culture, examined possible relationships between bisphenol A exposure and hormone levels in male workers. Exposed workers included 42 men in 3 Japanese plants who sprayed an epoxy hardening agent consisting of a mixture of bisphenol A diglycidyl ether (10-30%), toluene (0-30%), xylene (0-20%), 2-ethoxyethanol (0-20%), 2-butoxyethanol (0-20%), and methyl isobutyl ketone (0-30%).…”

Section: Experimental Animal Studies Considered Bymentioning

confidence: 99%

“…In 3 Japanese plants, exposed workers included 42 men who sprayed an epoxy hardening agent consisting of a mixture of bisphenol A diglycidyl ether (10-30%), toluene (0-30%), xylene (0-20%), 2-ethoxyethanol (0-20%), 2-butoxyethanol (0-20%), and methyl isobutyl ketone (0-30%) (Hanaoka et al, 2002). The workers wore ''protection devices'' during spraying.…”

Section: Fcpsa (2005)mentioning

confidence: 99%

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