Urinary cadmium and peripheral blood telomere length predict the risk of renal function impairment: a study of 547 community residents of Shanxi, China

Zhang, Jia‐Chen; Li, Shuang-Jing; Guo, Jianyong; Zhang, Guo-Yan; KANG, Hui; Shi, Xiujing; Zhou, Han; Liang, Yufen; Shen, Weitong; Li, Lei

doi:10.1007/s11356-022-20923-6

Cited by 3 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data imply that the prevalence of Cd-induced tubular dysfunction was likely to be smaller than 10% at E Cd /E cr 0.469 µg/g creatinine in men, and 0.733 µg/g creatinine in women. Of concern, these E Cd /E cr levels have been associated with increased risk of CKD in the general populations in the U.S. [ 49 ] Spain [ 50 ], Taiwan [ 51 ] and China [ 52 , 53 ]. Arguably, E β2M is not a sensitive toxicity endpoint and consequently the dietary exposure guideline of tolerable intake at 0.83 µg/kg body weight/day derived from E β2M /E cr ≥ 300 µg/g creatinine endpoint does not afford sufficient health protection.…”

Section: Discussionmentioning

confidence: 99%

The Validity of Benchmark Dose Limit Analysis for Estimating Permissible Accumulation of Cadmium

Satarug

Vesey

Gobé

et al. 2022

IJERPH

View full text Add to dashboard Cite

Cadmium (Cd) is a toxic metal pollutant that accumulates, especially in the proximal tubular epithelial cells of kidneys, where it causes tubular cell injury, cell death and a reduction in glomerular filtration rate (GFR). Diet is the main Cd exposure source in non-occupationally exposed and non-smoking populations. The present study aimed to evaluate the reliability of a tolerable Cd intake of 0.83 μg/kg body weight/day, and its corresponding toxicity threshold level of 5.24 μg/g creatinine. The PROAST software was used to calculate the lower 95% confidence bound of the benchmark dose (BMDL) values of Cd excretion (ECd) associated with injury to kidney tubular cells, a defective tubular reabsorption of filtered proteins, and a reduction in the estimated GFR (eGFR). Data were from 289 males and 445 females, mean age of 48.1 years of which 42.8% were smokers, while 31.7% had hypertension, and 9% had chronic kidney disease (CKD). The BMDL value of ECd associated with kidney tubular cell injury was 0.67 ng/L of filtrate in both men and women. Therefore, an environmental Cd exposure producing ECd of 0.67 ng/L filtrate could be considered as Cd accumulation levels below which renal effects are likely to be negligible. A reduction in eGFR and CKD may follow when ECd rises from 0.67 to 1 ng/L of filtrate. These adverse health effects occur at the body burdens lower than those associated with ECd of 5.24 µg/g creatinine, thereby arguing that current health-guiding values do not provide a sufficient health protection.

show abstract

Section: Discussionmentioning

confidence: 99%

The Validity of Benchmark Dose Limit Analysis for Estimating Permissible Accumulation of Cadmium

Satarug

Vesey

Gobé

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…When Cd-plated materials are exposed to the atmosphere, Cd corrodes and breaks down before the underlying material. In addition, some Cd may be released into the atmosphere or deposited on the ground during welding, cutting, or grinding [57]. Exposure to welding fumes has been implicated in increased urinary Cd and β2-microglobulinaemia, which implies that it leads to renal tubular dysfunction [58].…”

Section: Concentration and Inter-elemental Corrlation Of The Ptes In ...mentioning

confidence: 99%

Exposure and Health Risks Posed by Potentially Toxic Elements in Soils of Metal Fabrication Workshops in Mbarara City, Uganda

Nuwamanya,

Byamugisha,

Nakiguli

et al. 2024

JoX

View full text Add to dashboard Cite

Metal fabrication workshops (MFWs) are common businesses in Ugandan cities, and especially those producing metallic security gates, window and door frames (burglar-proof), and balcony and staircase rails. The objective of this study was to comparatively assess the pollution levels and potential health risks of manganese (Mn), chromium (Cr), cadmium (Cd), lead (Pd) and nickel (Ni) in pooled surface soil samples from four 5-, 7-, 8-, and 10-year-old MFWs (n = 28) and a control site (n = 8) in Mbarara City, Uganda. The concentration of the potentially toxic elements (PTEs) was determined using inductively coupled plasma–optical emission spectrometry. Contamination, ecological, and human health risk assessment indices and models were used to identify any risks that the PTEs could pose to the pristine environment and humans. Our results showed that PTE pollution of soils is occuring in the MFWs than at the control site. The mean concentrations of the PTEs (mg kg−1) in the samples were: Mn (2012.75 ± 0.23–3377.14 ± 0.31), Cr (237.55 ± 0.29–424.93 ± 0.31), Cd (0.73 ± 0.13–1.29 ± 0.02), Pb (107.80 ± 0.23–262.01 ± 0.19), and Ni (74.85 ± 0.25–211.37 ± 0.14). These results indicate that the PTEs could plausibly derive from the fabrication activities in these workshops, which is supported by the high values of contamination factors, index of geoaccumulation, and the overall increase in pollution load indices with the number of years of operation of the MFWs. Human health risk assessment showed that there are non-carcinogenic health risks that could be experienced by children who ingest PTEs in the soils from the 7-, 8- and 10-year-old MFWs. The incremental life cancer risk assessment suggested that there are potential cancerous health effects of Cd and Ni that could be experienced in children (who ingest soils from all the four MFWs) and adults (ingesting soils from the 8- and 10-year-old MFWs). This study underscores the need to implement regulatory guidelines on the operation and location of MFWs in Uganda. Further research should be undertaken to investigate the emission of the PTEs during welding operations in the MFWs.

show abstract

Review of Correlations Between Telomere Length and Metal Exposure Across Distinct Populations

Beddingfield,

Ji,

Zarus

et al. 2024

Environments

View full text Add to dashboard Cite

Telomere length (TL) predicts the onset of replicative senescence, and its shortening is a limiter on the number of divisions individual somatic cells can perform. Metal-induced genotoxic events are discussed in Agency for Toxic Substances and Disease Registry’s (ATSDR) toxicological profiles. In vivo and in vitro toxicological studies suggest the correlation between toxic metals and TL. However, the correlation between TL and exposure to toxic metals in human populations is unclear despite decades of observational research. We conducted a literature search within the ATSDR toxicological profiles and PubMed database for peer-reviewed articles as of 04/2023 discussing TL and metal exposure in human populations. Through review of the 272 publications meeting these criteria, we identified 25 observational studies that considered the correlation between TL and exposure to some or all of six metals: cadmium (Cd), arsenic (As), nickel (Ni), selenium (Se), lead (Pb), and cesium (Cs). Because reported effect sizes were often not comparable across studies, we performed a sign test based on the reported significance for each metal–TL correlation. We found that Cd was consistently significantly correlated with shorter telomeres (p = 0.016). However, no consistent linear relationship was observed between TL and any of the other metals considered. Exploring this association can enhance our understanding of how metal exposure may influence TL dysfunction. Our findings suggest that Cd exposure contributes to shorter TL, which may affect the DNA damage response (DDR) resulting in numerous chronic health conditions. Further, we highlight inconsistencies in findings on the correlation between metal exposure and TL across different populations and exposure levels. This suggests that correlations between some metals and TL may vary across populations, and that correlations may change at different exposure levels. Also, our findings suggest the need for further research on the potential for nonlinear relationships and non-additive effects of co-exposure to multiple hazardous metals, which could explain the inconsistencies observed across studies. The inconsistent incidences of metal–TL correlations justify additional exploration into the complex interaction between metals and TL.

show abstract

Urinary cadmium and peripheral blood telomere length predict the risk of renal function impairment: a study of 547 community residents of Shanxi, China

Cited by 3 publications

References 54 publications

The Validity of Benchmark Dose Limit Analysis for Estimating Permissible Accumulation of Cadmium

The Validity of Benchmark Dose Limit Analysis for Estimating Permissible Accumulation of Cadmium

Exposure and Health Risks Posed by Potentially Toxic Elements in Soils of Metal Fabrication Workshops in Mbarara City, Uganda

Review of Correlations Between Telomere Length and Metal Exposure Across Distinct Populations

Contact Info

Product

Resources

About