Urinary caffeine and its metabolites in association with advanced liver fibrosis and liver steatosis: a nationwide cross-sectional study

Dong, Rui; Zhang, Ru; Shen, Chao; Shen, Ya; Shen, Zhengkai; Tian, Ting; Wang, Jie

doi:10.1039/d3fo04957d

Food Funct.

2024

DOI: 10.1039/d3fo04957d

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Urinary caffeine and its metabolites in association with advanced liver fibrosis and liver steatosis: a nationwide cross-sectional study

Rui Dong,

Ru Zhang,

Chao Shen

et al.

Abstract: Aims: This study used urinary caffeine and its metabolites to evaluate its relationship with liver fibrosis and steatosis. Methods: A total of 2069 adult participants with needed data were filtrated...

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Cited by 2 publications

References 67 publications

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Cardiometabolic phenotype linked to fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease

Dong,

Tian,

Luo

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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Cardiometabolic phenotype linked to fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease

Dong,

Tian,

Luo

et al. 2024

Nutrition, Metabolism and Cardiovascular Diseases

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Association Between Dietary Flavonoid Intake and Cardiovascular Health in Cancer Survivors: A Cross-Sectional Study

Li,

Chen,

Xie

et al. 2024

JMDH

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Purpose Flavonoids are naturally occurring compounds with diverse health-promoting properties. The purpose of this study was to explore the associations between dietary flavonoid intake and cardiovascular health in cancer survivors. Patients and Methods We obtained data from the National Health and Nutrition Examination Survey (NHANES) 2007–2008, 2009–2010, and 2017–2018 cycles. Weighted linear regression and restricted cubic spline (RCS) were used to explore the correlation between dietary flavonoid intake and cardiovascular health (Life’s Essential 8 (LE8) score) in cancer survivors. Then, weighted quantile sum (WQS) regression and quantile-based g-computation (qgcomp) models were performed to assess the mixed effects of the six flavonoid subclasses and to determine the major flavonoid types. Additionally, the protective effect of high flavonoid intake on cardiovascular health was further evaluated in different subgroups, and mediation analysis was used to explore mediating factors. Results After adjusting for all covariates, compared to those in the first quartile, participants in the fourth quartile of total flavonoids, anthocyanidins, flavonols, flavanones, and flavones intake exhibited increases in LE8 scores of 3.24% (95% CI: 0.45–6.03, P for trend=0.030), 6.25% (95% CI: 3.14–9.36, P for trend<0.001), 3.01% (95% CI: 1.33–4.69, P for trend= 0.003), 3.23% (95% CI: 0.18–6.27, P for trend=0.030), and 5.01% (95% CI: 2.42–7.61, P for trend<0.001), respectively. Meanwhile, significant non-linear relationships were supported by the RCS models. However, the weighted linear regression and RCS models did not reveal any clear correlations between isoflavone or flavan-3-ol intake and the LE8 score. Regarding mixed effects, anthocyanidin, flavonol, flavanone, and flavone intake were positively related to the LE8 score according to both the WQS and qgcomp models, and anthocyanidin intake was the major contributor. Conclusion Our study indicated that dietary flavonoid intake is positively associated with cardiovascular health in cancer survivors, among which anthocyanidin intake might provide the most benefit.

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Urinary caffeine and its metabolites in association with advanced liver fibrosis and liver steatosis: a nationwide cross-sectional study

Abstract: Aims: This study used urinary caffeine and its metabolites to evaluate its relationship with liver fibrosis and steatosis. Methods: A total of 2069 adult participants with needed data were filtrated...

Cited by 2 publications

References 67 publications

Cardiometabolic phenotype linked to fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease

Cardiometabolic phenotype linked to fibrosis and mortality in metabolic dysfunction-associated steatotic liver disease

Association Between Dietary Flavonoid Intake and Cardiovascular Health in Cancer Survivors: A Cross-Sectional Study

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