Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstruction

Bartoli, Fabio; Rosa, Philippe; Aceto, Gabriella; Niglio, Francesco; D'Addato, Olinda; Pastore, Valentina; Campanella, Vittoria; Magaldi, Simona; Lasalandra, Carla; Bitonto, G Di; Gesualdo, Loreto

doi:10.1016/j.jpedsurg.2010.07.057

Cited by 62 publications

(50 citation statements)

References 21 publications

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“…In the studies conducted by Bartoli et al with children with UPO, they have showed that b 2 microglobulin levels are high in functional and obstructive congestion and that it drops in cases where the stenosis is eliminated with surgery. 26 In this experimental model, the increase of the urine values in Group UPO after stenosis demonstrates: b 2 microglobulin levels decreased back to its normal limits with alfuzosin treatment in Group UPT. Serum K, P, Cl, Ca, BUN, and creatinine levels in Group UPT administered with alfuzosin reaches back to its statistically significant normal values compared to Group UPO, and that its renal functions were conserved with alfuzosin treatment.…”

Section: Discussionmentioning

confidence: 61%

The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction

et al. 2016

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(2016) The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction, Renal Failure, Background: In this study, it was aimed to determine the effects of alfuzosin on experimentally generated unilateral partial ureteropelvic junction obstruction (UPO) in rats. Materials and methods: Thirty Long-Evans rats were randomly allocated into five groups. In control group (C), nothing was performed; in group Sham (S) only laparotomy was done; in Alfuzosin group (A) only alfuzosin was administered for two weeks (10 mg/kg/day p.o.) without any surgery; in UPO group, unilateral UP junction obstruction was produced; and in the Group UPT (ureteropelvic obstruction þ treatment), alfuzosin was administered for two weeks (10 mg/kg/day p.o.) in addition to UPO production. Renal pelvic anteroposterior diameters were determined with ultrasonography (USG) and renal arterial resistivity indexes by color Doppler USG. Urine was collected both at the beginning and at the end of the experiment for 24 h in all the groups and at the end of the experiment, blood samples were obtained. Blood and urine electrolytes and TGFb1, urine density, urine b 2 microglobulin levels were determined. Renal tissue samples harvested from all of the rats were histopathologically evaluated. Results were determined using one-way ANOVA t-test; p < 0.05 was accepted as significant. Results: Urine density in the UPT group was lower with respect to UPO group and blood electrolytes were preserved as close to normal (p < 0.05). In the UPT group, urine TGF-b1 and blood TGFb1, blood b 2 microglobulin levels and histopathologic damage scores were lower compared to the UPO group (p < 0.05). Conclusion: It is shown in this experimental unilateral partial UPO model that alfuzosin treatment prevents obstructive renal damage.

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Section: Discussionmentioning

confidence: 61%

The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction

et al. 2016

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“…For instance, CCL2/MCP-1 and CXCL8/IL-8 are the chemokines more commonly associated with pediatric renal diseases [7,11,12,15,16,19,20,46,47,55,58,[65][66][67][68][69][73][74][75].…”

Section: Discussionmentioning

confidence: 99%

“…In pediatric patients with CAKUT, the chemokine CCL2/MCP-1 has been associated with urinary tract obstruction in UPJO [65][66][67][68], whereas high urinary levels of CXCL8/IL-8 were found in VUR [73][74][75]. This chemokine has been also correlated to the presence of renal scarring [73] renal function deterioration in CAKUT patients [12].…”

Section: Discussionmentioning

confidence: 99%

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Chemokines as Potential Markers in Pediatric Renal Diseases

Silva¹,

Pereira²,

Teixeira³

et al. 2015

Biomarkers in Kidney Disease

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Glomerular diseases and obstructive uropathies are the two most frequent causes of chronic kidney disease (CKD) in children. Recently, biomarkers have become a focus of clinical research as potentially useful diagnostic tools in pediatric renal diseases. Among several putative biomarkers, chemokines emerge as promising molecules since they play relevant roles in the pathophysiology of pediatric renal diseases. The evaluation of these inflammatory mediators might help in the management of diverse renal diseases in children and the detection of patients at high risk to develop CKD. The aim of this paper is to revise general aspects of chemokines and the potential link between chemokines and the most common pediatric renal diseases by including experimental and clinical evidence.

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“…Bu histopatolojik değişikliklerden de renal kan akı-mının azalmasına yani iskemiye bağlı olarak üretimi artan bazı mediatörlerin ve serbest oksijen radikallerinin sorumlu olduğu gösterilmiştir (1,3,27,30) . Literatür-de tam veya kısmi ÜPB tıkanıklığında biyokimyasal, ultrastrüktürel ve fonksiyonel parametreler açısından karşı taraf böbrekte oluşan yanıtı inceleyen birkaç ça-lışma (2,7,26,32,33) vardır.…”

Section: Introductionunclassified

The early and late period alterations on the contralateral renal parenchyma secondary to unilateral ureteropelvic junction obstruction: experimental study

Kaçar¹,

Çetin²,

Çalışkan³

et al. 2010

TCCD

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Urinary epidermal growth factor, monocyte chemotactic protein-1, and β2-microglobulin in children with ureteropelvic junction obstruction

Cited by 62 publications

References 21 publications

The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction

The effect of alfuzosin on renal resistive index, urinary electrolytes and β2 microglobulin levels and TGF β-1 levels of kidney tissue in rats with unilateral ureteropelvic junction obstruction

Chemokines as Potential Markers in Pediatric Renal Diseases

The early and late period alterations on the contralateral renal parenchyma secondary to unilateral ureteropelvic junction obstruction: experimental study

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