Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea

Cho, Namjun; Kim, Dae-Yeon; Kwon, Soon Hyo; Ha, Tae Won; Kim, Hyun Kyu; Lee, Man Ryul; Chun, Sang Sik; Park, Samel; Lee, Eun-Young; Gil, Hyo‐Wook

doi:10.23876/j.krcp.21.015

Cited by 10 publications

(6 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, the literature has demonstrated a role for exosomes in physiological and pathological conditions, such as in the progression of cancer, which has been vastly described in the literature [ 17 , 18 , 19 , 20 ]. In addition, circulating and urinary exosomes are being used to identify key proteins and microRNA (miRNAs), circular RNAs (circRNA), or long non-coding RNA (lncRNA) associated with different diseases including type 2 diabetes, nephropathy, aldosteronism, atherosclerosis, and several types of cancer (bladder, gastric, prostate cancers) [ 21 , 22 , 23 , 24 , 25 ]. Therefore, it seems that the exosomes carry potential molecules to help in the diagnosis of diseases.…”

Section: Exosomesmentioning

confidence: 99%

Exosomes as Intercellular Messengers in Hypertension

Arishe

Priviero

Wilczynski

et al. 2021

IJMS

View full text Add to dashboard Cite

People living with hypertension have a higher risk of developing heart diseases, and hypertension remains a top cause of mortality. In hypertension, some detrimental changes occur in the arterial wall, which include physiological and biochemical changes. Furthermore, this disease is characterized by turbulent blood flow, increased fluid shear stress, remodeling of the blood vessels, and endothelial dysfunction. As a complex disease, hypertension is thought to be caused by an array of factors, its etiology consisting of both environmental and genetic factors. The Mosaic Theory of hypertension states that many factors, including genetics, environment, adaptive, neural, mechanical, and hormonal perturbations are intertwined, leading to increases in blood pressure. Long-term efforts by several investigators have provided invaluable insight into the physiological mechanisms responsible for the pathogenesis of hypertension, and these include increased activity of the sympathetic nervous system, overactivation of the renin–angiotensin–aldosterone system (RAAS), dysfunction of the vascular endothelium, impaired platelet function, thrombogenesis, vascular smooth muscle and cardiac hypertrophy, and altered angiogenesis. Exosomes are extracellular vesicles released by all cells and carry nucleic acids, proteins, lipids, and metabolites into the extracellular environment. They play a role in intercellular communication and are involved in the pathophysiology of diseases. Since the discovery of exosomes in the 1980s, numerous studies have been carried out to understand the biogenesis, composition, and function of exosomes. In this review, we will discuss the role of exosomes as intercellular messengers in hypertension.

show abstract

Section: Exosomesmentioning

confidence: 99%

Exosomes as Intercellular Messengers in Hypertension

Arishe

Priviero

Wilczynski

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…T2D urine miRNA studies mainly studied T2D patients with kidney complications [ 178 , 179 , 180 , 181 , 182 , 183 , 184 ], except one study compared patients with different T2D treatments [ 185 ] ( Table 10 ). Most studies profiled miRNAs from urinary exosomes, while a few profiled urine supernatants [ 178 , 184 ].…”

Section: Epigenomics Biomarkers For T2dmentioning

confidence: 99%

Circulating Nucleic Acid-Based Biomarkers of Type 2 Diabetes

Padilla-Martínez

Wojciechowska

Szczerbiński

et al. 2021

IJMS

View full text Add to dashboard Cite

Type 2 diabetes (T2D) is a deficiency in how the body regulates glucose. Uncontrolled T2D will result in chronic high blood sugar levels, eventually resulting in T2D complications. These complications, such as kidney, eye, and nerve damage, are even harder to treat. Identifying individuals at high risk of developing T2D and its complications is essential for early prevention and treatment. Numerous studies have been done to identify biomarkers for T2D diagnosis and prognosis. This review focuses on recent T2D biomarker studies based on circulating nucleic acids using different omics technologies: genomics, transcriptomics, and epigenomics. Omics studies have profiled biomarker candidates from blood, urine, and other non-invasive samples. Despite methodological differences, several candidate biomarkers were reported for the risk and diagnosis of T2D, the prognosis of T2D complications, and pharmacodynamics of T2D treatments. Future studies should be done to validate the findings in larger samples and blood-based biomarkers in non-invasive samples to support the realization of precision medicine for T2D.

show abstract

“…Several studies have showed that have potential renoprotective effects through reducing inflammation, fibrosis, and oxidative damage (Tanaka et al, 2014;Daza-Arnedo et al, 2021). In addition, DPP4i have been shown to provide renoprotective benefits in TAC-induced kidney injury through urinary exosome-derived miRNA profiling and anti-apoptotic effects (Huang et al, 2012;Cho et al, 2021). However, it remains unclear whether these protective effects can be further enhanced by combining DPP4i with GTE.…”

Section: Introductionmentioning

confidence: 99%

Synergistic Renoprotective Effects of Green Tea Extract and Gemigliptin against Tacrolimus-Induced Nephrotoxicity in Mice

Yoon,

Lee,

Kim

et al. 2024

Int. J. Morphol.

View full text Add to dashboard Cite

Although tacrolimus (TAC) significantly reduces allograft rejection incidence in solid-organ transplantation, its long-term use is associated with an increased risk of TAC-induced nephrotoxicity. In this study, we investigated the renoprotective effects of green tea extract (GTE) with or without the dipeptidyl peptidase 4 inhibitor, gemigliptin, by assessing serum creatinine levels, the amount of proteinuria, and histopathology in TAC-induced nephrotoxicity. TAC-induced nephrotoxicity was induced by intraperitoneal TAC injection, GTE was administered via subcutaneous injection, and gemigliptin was administered orally. Mice with TAC-induced nephrotoxicity exhibited a significant increase in both serum creatinine levels and 24-hour urine protein. However, when treated with GTE via subcutaneous injection, mice showed a decrease in serum creatinine levels and the amount of proteinuria. When GTE was combined with gemigliptin, further renoprotective effects were observed in biochemical assessments, consistent with the attenuation of TAC-induced nephrotoxicity in histopathology. The expression of p53 protein was lower in the mice treated with the combination of GTE and gemigliptin compared to mice with TAC-induced nephrotoxicity. Our results demonstrate that the combination of GTE and gemigliptin treatment reveals synergistic renoprotective effects by decreasing the expression of p53 protein. These findings suggest that the combination of GTE and gemigliptin could potentially be used as a prophylactic or therapeutic strategy for TAC-induced nephrotoxicity.

show abstract

Urinary exosomal microRNA profiling in type 2 diabetes patients taking dipeptidyl peptidase-4 inhibitor compared with sulfonylurea

Cited by 10 publications

References 31 publications

Exosomes as Intercellular Messengers in Hypertension

Exosomes as Intercellular Messengers in Hypertension

Circulating Nucleic Acid-Based Biomarkers of Type 2 Diabetes

Synergistic Renoprotective Effects of Green Tea Extract and Gemigliptin against Tacrolimus-Induced Nephrotoxicity in Mice

Contact Info

Product

Resources

About