2021
DOI: 10.21037/tau-20-1039
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Urinary extracellular vesicles: a rising star in bladder cancer management

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Cited by 13 publications
(9 citation statements)
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“…Cystoscopy is currently the standard test for diagnosis of bladder cancer; however, it is an invasive procedure and may lead to complications such as urethral perforation, hemorrhage, and infection . There have been a few attempts to analyze EVs as biomarkers that can provide an alternative source for non-invasive diagnostics. , To address the need for high-throughput clinical detection, we applied the one-pot EV proteomics pipeline to investigate the urinary EV proteomes from 37 patients already diagnosed with bladder cancer and 16 healthy individuals using 1 mL of urine from each. The clinical annotation of each sample is shown in Table S4.…”
Section: Resultsmentioning
confidence: 99%
“…Cystoscopy is currently the standard test for diagnosis of bladder cancer; however, it is an invasive procedure and may lead to complications such as urethral perforation, hemorrhage, and infection . There have been a few attempts to analyze EVs as biomarkers that can provide an alternative source for non-invasive diagnostics. , To address the need for high-throughput clinical detection, we applied the one-pot EV proteomics pipeline to investigate the urinary EV proteomes from 37 patients already diagnosed with bladder cancer and 16 healthy individuals using 1 mL of urine from each. The clinical annotation of each sample is shown in Table S4.…”
Section: Resultsmentioning
confidence: 99%
“…Presently, cytology is the only test implemented for assisting in BC patient management, used in complementarity with cystoscopy [ 9 ]. The FDA-approved urine-sediment-based tests for BC diagnosis and follow-up, mostly assessing proteins, metabolites, DNA, or mRNA, have not gained wide acceptance in clinical routine due to its low sensitivity for detecting early disease and its limited reproducibility [ 81 ]. Thus, novel molecular biomarkers are required to fill this gap.…”
Section: Discussionmentioning
confidence: 99%
“…Carcinogenic exosomes had an increase in unfolded endoplasmic reticulum proteins, which leads to the oxidative stress response mechanism within cells when they are proliferating quickly [ 82 ]. This oxidative stress phenomenon was observed in mice models utilizing bladder cancer cells [ 83 , 84 ]. Demonstrated using muscle invasive bladder cancer cells, the presence of EMT underscores the impact exosomes have in the setting of MIBC [ 84 ].…”
Section: Exosomes In Muscle Invasive Bladder Cancermentioning
confidence: 99%