Urinary hormone levels: a population study of associations between steroid and catecholamine excretion rates

Summers, Kim M.; Harrison, G. A.; Hume, David; Palmer, Charlotte

doi:10.1080/03014468300006241

Cited by 12 publications

(2 citation statements)

References 20 publications

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“…Sotsky and colleagues [ 19811 described a significant negative correlation between plasma norepinephrine response and percent cortisol suppression following dexamethasone. Urinary levels of steroid metabolites (17-hydroxycorticosteroids and 17-oxosteroids) were measured by Summers et al [1983] in over 400 males and compared to urinary levels of norepinephrine. Again, a strong positive relationship was noted between the two substances.…”

Section: Lhpa Dysregulation In Depressionmentioning

confidence: 99%

Hormonal mediation of the memory disorder in depression

Reus

1984

Drug Development Research

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Many patients with major depression show deficits in information processing to a degree that parallels the severity of the mood disorder. Parallel findings of alteration in hormonal systems known to modulate memory functions suggest that the biological and cognitive changes described may be functionally linked. A specific goal for norepinephrine and the limbic hypothalamic-pituitary-adrenal axis is hypothesized and related to specific components of the alteration in information processing. The cognitive and mood effects of stimulant compounds in normal and depressed patient populations and parallels between the biologic and cognitive changes seen in normal aging and those observed in depression are considered.

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Section: Lhpa Dysregulation In Depressionmentioning

confidence: 99%

Hormonal mediation of the memory disorder in depression

Reus

1984

Drug Development Research

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“…The field of human and non‐human primate evolutionary biology (HEB) has been a longtime leader in MIB research (for early examples of this work, see Brockman et al, 1995 ; Campbell, 1994 ; Ellison, 1988 ; Knott, 1997 ; Summers et al, 1983 ; Worthman & Stallings, 1997 ). In many respects, this position of leadership has emerged as a necessity for carrying out respectful and sustainable research with some of the world's most vulnerable human and comparative non‐human primate (NHP) populations.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive biomarkers in human and non‐human primate evolutionary biology: Tools for understanding variation and adaptation

Urlacher

Kim

Luan

et al. 2022

American J Hum Biol

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Background: The use of minimally invasive biomarkers (MIBsphysiological biomarkers obtained from minimally invasive sample types) has expanded rapidly in science and medicine over the past several decades. The MIB approach is a methodological strength in the field of human and non-human primate evolutionary biology (HEB). Among humans and our closest relatives, MIBs provide unique opportunities to document phenotypic variation and to operationalize evolutionary hypotheses.Aims: This paper overviews the use of MIBs in HEB. Our objectives are to (1) highlight key research topics which successfully implement MIBs,(2) identify promising yet under-investigated areas of MIB application, and(3) discuss current challenges in MIB research, with suggestions for advancing the field.

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Human salivary steroids: Methodological considerations and applications in physical anthropology

Ellison

1988

Am. J. Phys. Anthropol.

136

111

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The measurement of steroid hormones in saliva presents a number of attractive opportunities to physical anthropologists and human biologists in areas including reproductive ecology, growth and development, behavioral physiology, and nutrition. Among the key advantages of salivary steroid assays, as opposed to plasma or urinary assays, are the noninvasive and nondisruptive nature of sample collection. Significant disadvantages exist as well, stemming from the increased level of assay sensitivity required and the need for carefully controlled sample collection. Methodological aspects of research design, sample collection and handling, and data analysis and interpretation in the use of salivary steroid assays are discussed in detail, with special attention given to commonly overlooked but potentially crucial considerations. A review of potential applications within physical anthropology includes the use of testosterone assays in studies of male reproductive function and aggressive behavior; the use of adrenal androgen assays in studies of human growth and maturation; the use of cortisol assays in studies of stress physiology and limbic system arousal; and the use of ovarian steroids in studies of female reproductive function.Steroids, as a class of biologically active molecules, are among the most potent and pervasive regulators of vertebrate physiology. They help to regulate basic energy metabolism, both catabolic mobilization of energy and anabolic accumulation of tissue; they serve as primary regulators of adolescent growth and reproductive maturation; they directly determine primary and secondary sex characters; they are crucial in the regulation of adult reproductive function; and they help regulate mineral and electrolyte balance. They are also implicated in the control of libido, aggression, maternal behavior, stress, learning, personality development, and psychopathology. Along with primary sites of production in the gonads and adrenals, and sites of peripheral conversion throughout the body, including skin, muscles, adipose tissue, kidneys, lungs, and liver, they appear also to be synthesized directly in the brain (Le Goascogne et al., 1987). As a group, steroids readily permeate the blood-brain barrier and thus provide one of the primary links between systemic physiology and the central nervous system. It is little wonder, then, that steroids have been the object of intense scientific interest, that several primary research journals restrict themselves exclusively to the chemistry and biology of steroids, or that research reports focusing on steroid physiology are found in journals from fields as diverse as nutrition, psychology, neuroscience, anthropology, social deviance, and child development.The great proliferation of research into steroid physiology dates from the development of reliable assay methods in the 1960s. Berson and Yallow's Nobel Prizewinning technique of radioimmunoassay allowed accurate measurement of circulating steroids in serum and urine. Later outgrowths of this technique all...

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Urinary hormone levels: a population study of associations between steroid and catecholamine excretion rates

Cited by 12 publications

References 20 publications

Hormonal mediation of the memory disorder in depression

Hormonal mediation of the memory disorder in depression

Minimally invasive biomarkers in human and non‐human primate evolutionary biology: Tools for understanding variation and adaptation

Human salivary steroids: Methodological considerations and applications in physical anthropology

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