Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study

Yılmaz, Alev; Afonso, Alberto Caldas; Akil, İpek; Aksu, Bağdagül; Alpay, Harika; Atmış, Bahriye; Aydoğ, Özlem; Bayazıt, Aysun Karabay; Bayram, Meral Torun; Bilge, İlmay; Bulut, İpek Kaplan; Büyükkaragöz, Bahar; Çomak, Elif; Demir, Belde Kasap; Dinçel, Nida; Durmus, Mehmet Akif; Dursun, Hasan; Düşünsel, Ruhan; Düzova, Ali; Ertan, Pelin; Gedikbaşı, Asuman; Göknar, Nilüfer; Güven, Serçin; Hacıhamdioğlu, Duygu Övünç; Jankauskienė, Augustina; Kalyoncu, Mukaddes; Kavukçu, Salìh; Kenan, Bahriye Uzun; Küçük, Nuran; Kural, Bahar; Litwin, Mieczysław; Montini, Giovanni; Morello, William; Nayır, Ahmet; Obrycki, Łukasz; Ömer, Beyhan; Özdemir, Ebru Mısırlı; Özkayın, Neşe; Paripović, Dušan; Pehlivanoğlu, Cemile; Saygılı, Seha; Schaefer, Susanne; Sönmez, Ferah; Tabel, Yılmaz; Taş, Nesrin; Taşdemir, Mehmet; Teixeira, Ana; Tekcan, Demet; Tülpar, Sebahat; Türkkan, Özde Nisa; Uysal, Berfin; Uysalol, Metin; Vaičiūnienė, Daiva; Yavuz, Sevgi; Yel, Sibel; Yıldırım, Tarık; Yıldırım, Zeynep; Yıldız, Nurdan; Yüksel, Selçuk; Yurtseven, Eray; Schaefer, Franz; Topaloğlu, Rezan

doi:10.1007/s00467-022-05664-5

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…In our previous UTILISE study, we evaluated children with UTI and found increased uHSP70 levels during infection (2). The presence of CAKUT is one of the most important risk factors for developing UTI (10).…”

Section: Discussionmentioning

confidence: 99%

“…This study was planned as a part of UTILISE study, a prospective multicenter and multinational study (2). The UTILISE study had a group of patients with proven UTI (n=191); among them, we included those with CAKUT in the CAKUT-A group (n=89).…”

Section: Methodsmentioning

confidence: 99%

“…Urinary tract infection (UTI) is a common clinical finding in patients with CAKUT. The UTILISE (Urinary Tract Infection and Levels of heat shock protein 70 In children as a Sensitive marker for Excluding other infections) study showed that urine Heat Shock Protein 70 (uHSP70) is elevated during acute UTI and decreases after antibiotic treatment (2). HSPs are expressed in the kidneys in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stress (3).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

Aksu,

Afonso,

Akil

et al. 2024

Front. Urol.

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BackgroundCongenital anomalies of the kidney and urinary tract (CAKUT) are defined as structural malformations of the kidney and/or urinary tract. Heat shock proteins (HSPs) are expressed in the kidney in response to cellular changes, such as thermal, hemodynamic, osmotic, inflammatory, and mechanical stresses. This study aimed to assess uHSP70 levels during acute urinary tract infections (UTI) and non-infection periods in patients with CAKUT, and to evaluate whether uHSP70 is elevated in CAKUT subtypes.MethodsAmong patients with CAKUT, 89 patients with UTI (CAKUT-A), 111 without UTI (CAKUT-B), and 74 healthy children were included in the study. uHSP70 levels were measured using enzyme-linked immunosorbent assay (ELISA).ResultsuHSP70 level was significantly higher in the CAKUT-A group than in the CAKUT-B and healthy control groups (p < 0.0001). Moreover, the level of uHSP70 was significantly higher in the CAKUT-B group than in the control group (p < 0.0001), but was not different between the CAKUT subtypes (p > 0.05).ConclusionUrine HSP70 can also be used to predict UTI in patients with CAKUT. Moreover, uHSP70 levels were higher in children with CAKUT during the non-infectious period than in healthy controls. This suggests that children with CAKUT are at risk of chronic non-infectious damage.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%