Urinary Hydrogen Peroxide and Renal Function Parameter of Type 2 Diabetes Mellitus Patients Consuming Metformin and Metformin-Sulfonylurea

Sauriasari, Rani; Mahani, Mutiara; Sekar, Andisyah Putri; Azizahwat,

doi:10.5530/jyp.2017.1s.2

Cited by 3 publications

(4 citation statements)

References 15 publications

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“…There was no significant UACR difference (p=0.099) between groups. These results agree with a previous study [13]. The UACR in both groups was categorized as microalbuminuria in the 30-300 mg/g range.…”

Section: Resultssupporting

confidence: 93%

Urine Albumin-to-Creatinine Ratio and Estimated Glomerular Filtration Rate in Matched Groups of Type 2 Diabetes Mellitus Patients Receiving Metformin and Metformin-Sulfonylurea

2020

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Objective: Renal disease complications in type 2 diabetes mellitus patients are characterized by progressive urinary albumin excretion and decreasedglomerular filtration. The drugs most commonly prescribed as antidiabetic therapy in Indonesia are metformin and sulfonylurea. It is still unclearwhether the effect of metformin-sulfonylurea on kidney is different from that of metformin monotherapy.Methods: We compared the effectiveness of metformin monotherapy and metformin-sulfonylurea combination to the urine albumin-to-creatinineratio (UACR) and estimated glomerular filtration rate (eGFR) as renal function parameters. Study subjects were patients on either of these drugregimens for at least 1 year. We collected 88 samples from type 2 diabetes mellitus patients (37 patients on metformin and 51 on metforminsulfonylurea).The patients fasted for 8 h before urine and blood collection for UACR and eGFR analysis. We measured the eGFR using the chronickidney disease epidemiology collaboration (CKD-EPI) equation, serum creatinine, and urine creatinine by colorimetric enzymatic assay, and urinealbumin by immunoturbidimetry.Results: The eGFR level in the metformin and metformin-sulfonylurea groups was within the normal range, but lower in the metformin group(79.59±2.81) than in the metformin-sulfonylurea group (87.82±2.82) (p=0.018). In addition, hyperfiltration cases were more frequent in metforminsulfonylureagroup (p=0.029). The UACR in patients taking metformin-sulfonylurea (177.95±60.92) was higher than that in the metformin group(49.58±14.19) but the difference between them was not significant (p=0.099).Conclusion: Metformin monotherapy was associated with a lower frequency of hyperfiltration and lower UACR level compared to metforminsulfonylureacombination.

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Section: Resultssupporting

confidence: 93%

Urine Albumin-to-Creatinine Ratio and Estimated Glomerular Filtration Rate in Matched Groups of Type 2 Diabetes Mellitus Patients Receiving Metformin and Metformin-Sulfonylurea

2020

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“…In diabetes, glucose levels decrease and increase because of a lack of insulin. The pancreatic islets of Langerhans beta cells synthesize insulin . Nanomaterials are very important in industry because they have been used in many fields, such as medicine, plastics, ceramics, and the food industry, to detect poisonous chemicals.…”

Section: Introductionmentioning

confidence: 99%

“…The pancreatic islets of Langerhans beta cells synthesize insulin. 5 Nanomaterials are very important in industry because they have been used in many fields, such as medicine, plastics, ceramics, and the food industry, to detect poisonous chemicals. They determine diverse biological chemicals, like glucose, H 2 O 2 , uric acid, and dopamine.…”

Section: Introductionmentioning

confidence: 99%

Designing Nanocomposite-Based Electrochemical Biosensors for Diabetes Mellitus Detection: A Review

Guo,

Wang,

et al. 2024

ACS Omega

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This review will unveil the development of a new generation of electrochemical sensors utilizing a transition-metal-oxide-based nanocomposite with varying morphology. There has been considerable discussion on the role of transition metal oxide-based nanocomposite, including iron, nickel, copper, cobalt, zinc, platinum, manganese, conducting polymers, and their composites, in electrochemical and biosensing applications. Utilizing these materials to detect glucose and hydrogen peroxide selectively and sensitively with the correct chemical functionalization is possible. These transition metals and their oxide nanoparticles offer a potential method for electrode modification in sensors. Nanotechnology has made it feasible to develop nanostructured materials for glucose and H 2 O 2 biosensor applications. Highly sensitive and selective biosensors with a low detection limit can detect biomolecules at nanomolar to picomolar (10 −9 to 10 −12 molar) concentrations to assess physiological and metabolic parameters. By mixing carbon-based materials (graphene oxide) with inorganic nanoparticles, nanocomposite biosensor devices with increased sensitivity can be made using semiconducting nanoparticles, quantum dots, organic polymers, and biomolecules.

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“…Peroxides, free radicals, protein-, lipid- and DNA-modified substances are oxidative stress-related markers that have a pivotal role in cell damage [ 7 , 8 ]. Hydrogen peroxide (H 2 O 2 ) is one of a few peroxides used as a biomarker of oxidative stress [ 9 , 10 ]. The unique characteristic of H 2 O 2 is its ability to diffuse into the cell, forming hydroxyl radicals, and has the potential to attack biological molecules such as DNA, proteins, and lipids leading to cell damage [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Role of urinary H2O2, 8-iso-PGF2α, and serum oxLDL/β2GP1 complex in the diabetic kidney disease

et al. 2022

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Oxidant species is reported as a major determinant in the pathophysiology of diabetic kidney disease. However, reactive oxygen species (ROS) formation in the initial phase and progressing phase of diabetic kidney disease remains unclear. Therefore, we conducted this study to find out what ROS and their modified product are associated with eGFR in type 2 diabetes mellitus (T2DM) patients. A cross-sectional study was performed on 227 T2DM patients. The study subjects were divided into three groups based on their eGFR stage (Group 1, eGFR > 89 ml/min/1.73 m2; Group 2, eGFR = 60–89 ml/min/1.73 m2; and Group 3, eGFR < 60 ml/min/1.73 m2). Enzyme-linked immunosorbent assay (ELISA) was used to measure serum oxLDL/β2GPI complex and urinary 8-iso-PGF2α, while ferrous ion oxidation xylenol orange method 1 (FOX-1) was used to measure urinary hydrogen peroxide (H2O2). H2O2 significantly decreased across the groups, whereas OxLDL/β2GPI complex increased, but not significant, and there was no trend for 8-iso-PGF2α. Consistently, in the total study population, only H2O2 showed correlation with eGFR (r = 0.161, p = 0.015). Multiple linear regression analysis showed that significant factors for increased eGFR were H2O2, diastolic blood pressure, and female. Whereas increased systolic blood pressure and age were significant factors affecting the decrease of eGFR. We also found that urinary H2O2 had correlation with serum oxLDL/β2GPI complex in total population. This finding could lead to further research on urinary H2O2 for early detection and research on novel therapies of diabetic kidney disease.

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Urinary Hydrogen Peroxide and Renal Function Parameter of Type 2 Diabetes Mellitus Patients Consuming Metformin and Metformin-Sulfonylurea

Cited by 3 publications

References 15 publications

Urine Albumin-to-Creatinine Ratio and Estimated Glomerular Filtration Rate in Matched Groups of Type 2 Diabetes Mellitus Patients Receiving Metformin and Metformin-Sulfonylurea

Urine Albumin-to-Creatinine Ratio and Estimated Glomerular Filtration Rate in Matched Groups of Type 2 Diabetes Mellitus Patients Receiving Metformin and Metformin-Sulfonylurea

Designing Nanocomposite-Based Electrochemical Biosensors for Diabetes Mellitus Detection: A Review

Role of urinary H2O2, 8-iso-PGF2α, and serum oxLDL/β2GP1 complex in the diabetic kidney disease

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