Urinary Isoxanthopterin in Heart Failure Patients

Abstract

is a useful marker to assess systemic oxidative stress. 4 Thus, U-IXP may be a promising novel marker to assess the degree of ROS activity and to predict mortality and morbidity in heart failure patients. 5 Although several biomarkers are clinically available to predict prognosis in heart failure patients, U-IXP has the advantages of being a non-invasive marker and being uniquely associated with the ROS system. In this study we investigated the association between U-IXP and clinical outcomes in heart failure patients. Methods Patient SelectionPatients who were admitted to our institute for the treatment of decompensated heart failure between July 2019 and September 2020 were prospectively included in the present study. Patients aged <20 years, those admitted at the weekend, those who had undergone cardiac intervention within the past 1 month, and those who declined to take part in the study were excluded. All patients provided written informed consent. This study was approved by the Clinical

Pathophysiology of chikungunya virus infection associated with fatal outcomes

“…The CHIK fatality patients also showed a substantial reduction in isoxanthopterin in the serum, suggesting oxidative stress, as well as liver and renal damage. 49 , 50 We also found a significant increase in N-acyl amides (i.e., anandamide and N-stearoyl-proline) in CHIK patients with fatal outcomes; these metabolites are biologically active, endogenous ligands that bind to transient receptor potential (TRP) channels. Within TRPs, the TRP-vanilloid (TRPV) family exerts a role in mechanisms of pain and inflammation.…”

Urinary isoxanthopterin as a novel predictor following catheter ablation for atrial fibrillation

“…However, given its complexity to quantify the degree of oxidative stress, their detailed association remains uncertain. Recently, urinary isoxanthopterin (U‐IXP), which is converted from pterin mainly by xanthine oxidase, was proposed as a novel biomarker to predict clinical outcomes in the heart failure cohort 11 . We hypothesized that baseline U‐IXP might be an independent marker to predict AF recurrence following catheter ablation.…”