Urinary metals and maternal circulating extracellular vesicle microRNA in the MADRES pregnancy cohort

Howe, Caitlin G.; Foley, Helen; Farzan, Shohreh F.; Chavez, Thomas; Johnson, Mark; Meeker, John D.; Bastain, Theresa M.; Marsit, Carmen J.; Breton, Carrie V.

doi:10.1080/15592294.2021.1994189

Cited by 14 publications

(15 citation statements)

References 104 publications

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“…Some ncRNA types are preferred over others for use as biomarkers due to their prevalence in common human samples including urine, blood, saliva, and cell-free RNA sources. , Their prevalence can be attributed in part to their stability, which is conferred by localization or unique structural features. miRNA and circRNA can be excreted to extracellular fluid and harbored by exosomes, extracellular vesicles, or proteins, which protect the miRNA from degradation. , On the other hand, piRNA biomarkers typically contain a 2′- O -methylation at their 3′ end, which increases stability and resists degradation by ribonucleases, , while circRNAs are resistant to exonuclease RNase R …”

Section: Challenges and Opportunities In Toxicoepigeneticsmentioning

confidence: 99%

“…miRNA is the most extensively studied class of ncRNA biomarkers in toxicological research. Numerous studies have highlighted miRNA biomarkers in response to cadmium, mercury, and other metals, as well as radiation, environmental stress, particulate matter, and diseases. Due to miRNA versatility and the growing body of toxicological research, routine evaluation of miRNA biomarker detection methods and regulatory mechanisms is required to advance future miRNA research.…”

Section: Challenges and Opportunities In Toxicoepigeneticsmentioning

confidence: 99%

“…In a small number of studies, lncRNAs have been linked to environmental exposures including phthalates, cadmium, BPA, benzene, ethanol, and certain human diseases. , A typical imprinted gene cluster contains at least one lncRNA that regulates the DNA methylation imprint at a given imprinted locus . Toxicological studies may also include lncRNA biomarkers associated with imprinting.…”

Section: Challenges and Opportunities In Toxicoepigeneticsmentioning

confidence: 99%

“…miRNA and circRNA can be excreted to extracellular fluid and harbored by exosomes, extracellular vesicles, or proteins, which protect the miRNA from degradation. 233,234 On the other hand, piRNA biomarkers typically contain a 2′-O-methylation at their 3′ end, which increases stability and resists degradation by ribonucleases, 235,236 while circRNAs are resistant to exonuclease RNase R. 237 miRNA is the most extensively studied class of ncRNA biomarkers in toxicological research. Numerous studies have highlighted miRNA biomarkers in response to cadmium, 238 mercury, 233 and other metals, 239 as well as radiation, 234 environmental stress, 240 particulate matter, 241 and diseases.…”

Section: Informationmentioning

confidence: 99%

“…233,234 On the other hand, piRNA biomarkers typically contain a 2′-O-methylation at their 3′ end, which increases stability and resists degradation by ribonucleases, 235,236 while circRNAs are resistant to exonuclease RNase R. 237 miRNA is the most extensively studied class of ncRNA biomarkers in toxicological research. Numerous studies have highlighted miRNA biomarkers in response to cadmium, 238 mercury, 233 and other metals, 239 as well as radiation, 234 environmental stress, 240 particulate matter, 241 and diseases. Due to miRNA versatility and the growing body of toxicological research, routine evaluation of miRNA biomarker detection methods and regulatory mechanisms is required to advance future miRNA research.…”

Section: Informationmentioning

confidence: 99%

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Toxicoepigenetics and Environmental Health: Challenges and Opportunities

Svoboda

Perera

Morgan

et al. 2022

Chem. Res. Toxicol.

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The rapidly growing field of toxicoepigenetics seeks to understand how toxicant exposures interact with the epigenome to influence disease risk. Toxicoepigenetics is a promising field of environmental health research, as integrating epigenetics into the field of toxicology will enable a more thorough evaluation of toxicant-induced disease mechanisms as well as the elucidation of the role of the epigenome as a biomarker of exposure and disease and possible mediator of exposure effects. Likewise, toxicoepigenetics will enhance our knowledge of how environmental exposures, lifestyle factors, and diet interact to influence health. Ultimately, an understanding of how the environment impacts the epigenome to cause disease may inform risk assessment, permit noninvasive biomonitoring, and provide potential opportunities for therapeutic intervention. However, the translation of research from this exciting field into benefits for human and animal health presents several challenges and opportunities. Here, we describe four significant areas in which we see opportunity to transform the field and improve human health by reducing the disease burden caused by environmental exposures. These include (1) research into the mechanistic role for epigenetic change in environment-induced disease, (2) understanding key factors influencing vulnerability to the adverse effects of environmental exposures, (3) identifying appropriate biomarkers of environmental exposures and their associated diseases, and (4) determining whether the adverse effects of environment on the epigenome and human health are reversible through pharmacologic, dietary, or behavioral interventions. We then highlight several initiatives currently underway to address these challenges.

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Section: Challenges and Opportunities In Toxicoepigeneticsmentioning

confidence: 99%

Section: Challenges and Opportunities In Toxicoepigeneticsmentioning

confidence: 99%

Section: Challenges and Opportunities In Toxicoepigeneticsmentioning

confidence: 99%

Section: Informationmentioning

confidence: 99%

Section: Informationmentioning

confidence: 99%

See 3 more Smart Citations

Toxicoepigenetics and Environmental Health: Challenges and Opportunities

Svoboda

Perera

Morgan

et al. 2022

Chem. Res. Toxicol.

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The impact of environmental contaminants on extracellular vesicles and their key molecular regulators: A literature and database‐driven review

Carberry

Rager

2022

Environ and Mol Mutagen

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Exposure to environmental chemicals is now well recognized as a significant factor contributing to the global burden of disease; however, there remain critical gaps in understanding the types of biological mechanisms that link environmental chemicals to adverse health outcomes. One type of mechanism that remains understudied involves extracellular vesicles (EVs), representing small cell-derived particles capable of carrying molecular signals such as RNAs, miRNAs, proteins, lipids, and chemicals through biological fluids and imparting beneficial, neutral, or negative effects on target cells. In fact, evidence is just now starting to grow that supports the role of EVs in various disease etiologies. This review aims to (1) Provide a landscape of the current understanding of the functional relationship between EVs and environmental chemicals; (2) Summarize current knowledge of EV regulatory processes including production, packaging, and release; and (3) Conduct a database-driven analysis of known chemical-gene interactions to predict and prioritize environmentally relevant chemicals that may impact EV regulatory genes and thus EV regulatory processes. This approach to predicting environmentally relevant chemicals that may alter EVs provides a novel method for evidence-based hypothesis generation for future studies evaluating the link between environmental exposures and EVs.

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