Urinary Netrin-1: A New Biomarker for the Early Diagnosis of Renal Damage in Obese Children

Hacıhamdioğlu, Duygu Övünç; Hacıhamdioğlu, Bülent; Altun, Demet; Müftüoğlu, Tuba; Karademır, Ferhan; Süleymanoğlu, Selami

doi:10.4274/jcrpe.2828

Cited by 13 publications

(12 citation statements)

References 27 publications

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“…New biomarkers are necessary for early diagnosis of obesity-related renal damage and determining necessary interventions. For this purpose, tubular injury biomarkers, such as kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), neutrophil gelatinase-associated lipocalin (NGAL), and netrin-1, were recently investigated in patients with obesity [ 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Are there any new reliable markers to detect renal injury in obese children?

et al. 2018

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Aim: The aim of this study was to examine the serum and urine levels of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin (OPN), matrix metalloproteinase-9 (MMP-9), and serum Cystatin-C to determine the renal effect of obesity in obese children.Methods: Seventy-two obese and 35 non-obese healthy children were included in this study. Blood pressure (BP) was evaluated with office measurement. Creatinine, cystatin C, lipids, fasting glucose, and insulin levels were measured, and homeostasis model assessment -insulin resistance (HOMA-IR) was calculated. The urine albumin/creatinine ratio was calculated. The serum and urine KIM-1, NGAL, OPN, and MMP-9 levels were measured.Results: Serum cystatin-C, triglyceride, and homeostasis model assessment-insulin resistance (HOMA-IR) index were found to be significantly higher in the obese group (p = .0001), and high-density lipoprotein (HDL) cholesterol was found to be significantly lower (p = .019) in the obese group. No significant differences were found in serum KIM-1, NGAL, OPN or MMP-9 levels between groups (p > .05). No significant differences were found in urine KIM-1 and MMP-9 levels (p > .05), Urine NGAL, and OPN levels were found significantly higher in obese groups (p < .05).Conclusions: According to our results, although serum KIM-1, NGAL, OPN, MMP-9, and urine MMP-9, urine KIM-1 do not appear to be ideal markers to evaluate renal injury in the early period of obesity, the serum levels of cystatin C and urine NGAL, urine OPN can be used as a good marker for assessing the renal effect of obesity which can lead end stage renal disease in pediatric population.

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Section: Discussionmentioning

confidence: 99%

Are there any new reliable markers to detect renal injury in obese children?

et al. 2018

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Section: Discussionmentioning

confidence: 99%

“…There are also only a few studies in older children [9,18]. A study by Övünç Hacıhamdioğlu et al found that the value of urinary netrin 1/crea in healthy controls was (mean ± SD) 240.9 (123.5-450.2) pg/mg crea [9]. Ramesh et al in a study in patients after cardiopulmonary bypass gave the results of urinary netrin-1 in healthy controls in the range 100-200 pg/mg crea [18].…”

Section: Discussionmentioning

confidence: 99%

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Urinary netrin-1 concentration in healthy full-term newborns

et al. 2021

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IntroductionMonitoring of renal function in acute kidney injury in the pediatric population is complicated by the lack of age-related reference values of new biomarkers. Urinary netrin-1 is a new marker to demonstrate early kidney damage. Netrin-1 has a molecular mass of 72 kDa. It is therefore unlikely that it is filtered by the glomerulus under normal conditions. However, netrin-1 is highly induced after acute and chronic kidney injury and excreted in urine in humans. The aim of the study was to determine the normal concentrations of urinary netrin-1 in healthy full-term newborns.Material and methodsThe study included 88 healthy full-term neonates (51 boys and 37 girls) born from normal, uncomplicated pregnancies. The concentration of netrin-1 was determined in urine obtained on the first or second day of life with a commercially available ELISA kit.ResultsThe urinary concentration of netrin-1 in newborns was independent of gender and time of urine collection. We found a negative correlation between both the urinary netrin-1 concentration and urinary netrin-1 concentration after normalization for urinary creatinine and the birth weight.ConclusionsThis is the first study showing the urinary netrin-1 concentration in healthy full-term newborns. Future investigation is needed to confirm its potential role as a marker of kidney function in this age group.

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“…This peptide is comprised of nearly six hundred residues of an amino-terminal domain VI, followed by 3 laminin-type epidermal growth factor replications (V-1, V-2, and V-3) and a carboxy-terminal domain [ 25 , 26 ] as illustrated in Figure 1 . The biological roles of Netrin is mediated through two well-recognized receptor families, namely, the deleted receptors in colorectal cancer (DCC) and the uncoordinated 5 (UNC5) receptors [ 27 , 28 ], but added receptors such as CD146, also termed melanoma cell adhesion molecule and Down syndrome cell adhesion molecule, might also be involved [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications

Yimer

Zewdie

Hishe

2018

Journal of Diabetes Research

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Diabetes is a multifactorial metabolic syndrome and is one of the shared long-lasting illnesses globally. It is linked to long-term microvascular and macrovascular complications that contribute to disability, compromised quality of life, and reduction in lifespan, which eventually leads to death. This disease is not only incurring significant economic burden but also adversely affects the patients, caregivers, communities, and the society at large. The interruption of diabetes progress and its complications is a primary focus of scientific communities. In spite of various diagnostic modalities for diabetes, there is a limited marker to investigate the risk and progress of its complications. Netrin has recently received more attention as a biomarker of diabetes and a broader range of long-term complication. Therefore, the impetus of this review is to exhaustively discuss the role of Netrin as a potential biomarker and its therapeutic implication in diabetes and diverse sets of microvascular and macrovascular complications of diabetes. It also discourses the possible mechanisms of Netrin for the said pharmacological effect for a better understanding of the development and progression of diabetes and its complications in relation to this protein. It enables protective measures to be applied at the subclinical stage and the responses to preventive or therapeutic measures to be scrutinized. Besides, it might also facilitate the appraisal of novel therapeutic options for diabetes and various complications through modifying the endogenous Netrin and provide surrogate endpoints for intervention.

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Urinary Netrin-1: A New Biomarker for the Early Diagnosis of Renal Damage in Obese Children

Cited by 13 publications

References 27 publications

Are there any new reliable markers to detect renal injury in obese children?

Are there any new reliable markers to detect renal injury in obese children?

Urinary netrin-1 concentration in healthy full-term newborns

Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications

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