Urinary phthalate metabolites among elementary school children of Korea: Sources, risks, and their association with oxidative stress marker

Kim, Sunmi; Kang, Seok Kwon; Lee, Gowoon; Lee, Saeram; Jo, Areum; Kwak, Kyunghee; Kim, Dohyung; Koh, Dohyun; Kho, Younglim; Kim, Sungkyoon; Choi, Kyungho

doi:10.1016/j.scitotenv.2013.10.118

Cited by 64 publications

(35 citation statements)

References 55 publications

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“…Because of their ubiquitous exposure, phthalates are commonly detected in human samples (Kim et al 2014). Epidemiologic research has found associations between exposure to phthalates and various adverse health outcomes, including altered male reproductive development and function, altered thyroid function, increased waist circumference and insulin resistance, decreased gestational age or increased risk of premature birth, and respiratory symptoms and asthma (Ferguson et al 2011).…”

Section: Motivating Examplementioning

confidence: 99%

Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting

Carrico

Gennings

Wheeler

et al. 2014

JABES

861

492

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In risk evaluation, the effect of mixtures of environmental chemicals on a common adverse outcome is of interest. However, due to the high dimensionality and inherent correlations among chemicals that occur together, the traditional methods (e.g. ordinary or logistic regression) suffer from collinearity and variance inflation, and shrinkage methods have limitations in selecting among correlated components. We propose a weighted quantile sum (WQS) approach to estimating a body burden index, which identifies “bad actors” in a set of highly correlated environmental chemicals. We evaluate and characterize the accuracy of WQS regression in variable selection through extensive simulation studies through sensitivity and specificity (i.e., ability of the WQS method to select the bad actors correctly and not incorrect ones). We demonstrate the improvement in accuracy this method provides over traditional ordinary regression and shrinkage methods (lasso, adaptive lasso, and elastic net). Results from simulations demonstrate that WQS regression is accurate under some environmentally relevant conditions, but its accuracy decreases for a fixed correlation pattern as the association with a response variable diminishes. Nonzero weights (i.e., weights exceeding a selection threshold parameter) may be used to identify bad actors; however, components within a cluster of highly correlated active components tend to have lower weights, with the sum of their weights representative of the set.

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Section: Motivating Examplementioning

confidence: 99%

Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting

Carrico

Gennings

Wheeler

et al. 2014

JABES

861

492

View full text Add to dashboard Cite

show abstract

“…Oxidative stress and inflammation have been found to be the root cause of some adverse health effects induced by phthalates in both humans (Ferguson et al, 2011;Ambruosi et al, 2011;Kim et al, 2014;North et al, 2014) and animals (Zhou et al, 2011;Kasahara et al, 2002;Zuo et al, 2014). For example, 1000 mg/kg DEHP exposure by gavage can cause lipid peroxidation in the liver of rats (Erkekoglu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma

You

Chen

Mao

et al. 2014

Food and Chemical Toxicology

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Di-(2-ethylhexyl) phthalate, as the most commonly used plasticizer, is considered to be related to the asthma prevalence. There are studies affirming that the DEHP has an adjuvant effect in the pathogenesis of allergy asthma. Oxidative stress is one possible pathway for DEHP-adjuvant effect. Thus, this study explored whether DEHP could induce adjuvant effect in mouse asthma model via oxidative stress pathway. Male BALB/c mice were randomly divided into six groups: (1) saline group, (2) DEHP group, (3) ovalbumin (OVA) group, (4) DEHP+OVA group, (5) OVA+vitamin E (Vit E) group, (6) DEHP+OVA+Vit E group. The exposure dose of DEHP was 30 mg/kg body weight (bw)/day. After 18 days of the exposure protocol. Reactive oxygen species (ROS), glutathione (GSH) and malonaldehyde (MDA) levels and biomarkers related to asthma model were measured. Collectively, these data indicated higher ROS and MDA levels and lower GSH contents in DEHP+OVA group than that in OVA group, while Vit E, an antioxidant, could restore ROS, MDA and GSH levels to control levels and attenuate the DEHP and/or OVA effects. Our observations suggested that there was a relationship between oxidative stress and the adjuvant effect induced by DEHP in this mouse asthma model.

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“…After exposure to DEHP during prepuberty and puberty, significant decrease in GSH/GSSG redox ratio (>10-fold) and marked increase in TBARS levels were observed [10]. Epidemiological study also shows that urinary oxidative stress marker malondialdehyde (MDA) concentrations were significantly associated with several DEHP metabolite levels in prepubertal children [11]. …”

Section: Introductionmentioning

confidence: 99%

Prepubertal Exposure to Genistein Alleviates Di-(2-ethylhexyl) Phthalate Induced Testicular Oxidative Stress in Adult Rats

Zhang

Chong

et al. 2014

BioMed Research International

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Di-(2-ethylhexyl) phthalate (DEHP) is the most widely used plastizer in the world and can suppress testosterone production via activation of oxidative stress. Genistein (GEN) is one of the isoflavones ingredients exhibiting weak estrogenic and potentially antioxidative effects. However, study on reproductive effects following prepubertal multiple endocrine disrupters exposure has been lacking. In this study, DEHP and GEN were administrated to prepubertal male Sprague-Dawley rats by gavage from postnatal day 22 (PND22) to PND35 with vehicle control, GEN at 50 mg/kg body weight (bw)/day (G), DEHP at 50, 150, 450 mg/kg bw/day (D50, D150, D450) and their mixture (G + D50, G + D150, G + D450). On PND90, general morphometry (body weight, AGD, organ weight, and organ coefficient), testicular redox state, and testicular histology were studied. Our results indicated that DEHP could significantly decrease sex organs weight, organ coefficient, and testicular antioxidative ability, which largely depended on the dose of DEHP. However, coadministration of GEN could partially alleviate DEHP-induced reproductive injuries via enhancement of testicular antioxidative enzymes activities, which indicates that GEN has protective effects on DEHP-induced male reproductive system damage after prepubertal exposure and GEN may have promising future in its curative antioxidative role for reproductive disorders caused by other environmental endocrine disruptors.

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Urinary phthalate metabolites among elementary school children of Korea: Sources, risks, and their association with oxidative stress marker

Cited by 64 publications

References 55 publications

Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting

Characterization of Weighted Quantile Sum Regression for Highly Correlated Data in a Risk Analysis Setting

The adjuvant effect induced by di-(2-ethylhexyl) phthalate (DEHP) is mediated through oxidative stress in a mouse model of asthma

Prepubertal Exposure to Genistein Alleviates Di-(2-ethylhexyl) Phthalate Induced Testicular Oxidative Stress in Adult Rats

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