Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003–2008

Farzan, Shohreh F.; Chen, Yu; Trachtman, Howard; Trasande, Leonardo

doi:10.1016/j.envres.2015.11.012

Cited by 104 publications

(56 citation statements)

References 79 publications

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“…31, 32 Studies of other populations at levels more similar to those observed presently have detected associations with these and other oxidative stress biomarkers as well. 33, 34 In regard to pregnant women specifically, this is the first study to examine associations between urinary PAH biomarkers and 8-OHdG, 8-iso, and the tyrosine adducts during gestation. Another study of 2-NAP and 1-PYR reported associations with increases in malondialdehyde, another biomarker of oxidative lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Ferguson

McElrath

Pace

et al. 2017

Environ. Sci. Technol.

104

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Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) is prevalent and may adversely impact pregnancy and development of the fetus. The purpose of this exploratory study was to examine urinary PAH metabolites in association with mediators of these outcomes. To do so we measured a panel of 12 inflammatory, angiogenic, and oxidative stress biomarkers in plasma or urine from women in their third trimester of pregnancy (n=200). Urinary PAH metabolites were highly detectable (>88%) in the study population, and most were higher in women who had lower education levels, higher body mass index, and who were African American. Some PAH metabolites showed consistent positive associations with the plasma inflammation marker C-reactive protein (CRP) and the urinary oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. For example, an interquartile range increase in 2-hydroxynapthalene was associated with a 35% increase in CRP (95% confidence interval = −0.13, 83.2), a 14% increase in 8-OHdG (95% confidence interval = 0.59, 30.1), and a 48% increase in 8-isoprostane (95% confidence interval = 16.7, 87.0). These data suggest that exposure to PAHs may cause systemic changes during pregnancy that could lead to adverse pregnancy or developmental outcomes; however, these results should be corroborated in a larger study population.

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Section: Discussionmentioning

confidence: 99%

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Ferguson

McElrath

Pace

et al. 2017

Environ. Sci. Technol.

104

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“…One study used a dipstick to measure proteinuria (Factor-Litvak et al, 1999). Among the studies that examined estimated glomerular filtration rate (eGFR), seven studies used creatinine based estimating equations (Fadrowski et al, 2010, Farzan et al, 2016, Garcia-Esquinas et al, 2013, Kataria et al, 2015a, Kooijman et al, 2015, Loghman-Adham, 1998, Watkins et al, 2013). Four studies used Cystatin C based estimating equations to determine eGFR (Fadrowski et al, 2010, Skroder et al, 2015, Hawkesworth et al, 2013, Filler et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

“…These include studies of fluoride levels(Xiong et al, 2007; Liu et al, 2005), aflatoxin (Hassan et al, 2006a) and ochratoxin (Hassan et al, 2006b), maternal smoking levels (Taal et al, 2011, Kooijman et al, 2015), secondhand smoking (Garcia-Esquinas et al, 2013), Bisphenol A, Triclosan, Benzophenone-3 (Trasande et al, 2013), PFOA (Geiger et al, 2013; Watkins et al, 2013; Kataria et al, 2015a), Bisphenol-A-glycidyl-dimethacrylate (bisGMA) (Trachtenberg et al, 2014), melamine exposure (Lam et al, 2008; Guan et al, 2009), polycyclic aromatic hydrocarbons (PAHs) (Farzan et al, 2016) and various phthalate compounds (Trasande et al, 2014, Tsai et al, 2016) (Table 3). The study designs included 12 cross-sectional, 1 case control, 2 prospective cohort, 1 retrospective cohort, and 1 randomized clinical trial.…”

Section: Resultsmentioning

confidence: 99%

“…A cross-sectional study of 660 children in the United States found that out of 10 PAH compounds, only 3-Hydroxyphenanthrene was associated with a statistically significant decrease in eGFR in children (Farzan et al, 2016). All other PAH metabolites were not significantly associated with a decrease in eGFR or an increase in albumin/creatinine ratio (Farzan et al, 2016). …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Environmental exposures and pediatric kidney function and disease: A systematic review

Zheng

Sanders

Saland

et al. 2017

Environmental Research

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Background Environmental chemical exposures have been implicated in pediatric kidney disease. No appraisal of the available evidence has been conducted on this topic. Methods We performed a systematic review of the epidemiologic studies that assessed association of environmental exposures with measures of kidney function and disease in pediatric populations. The search period went through July 2016. Results We found 50 studies that met the search criteria and were included in this systematic review. Environmental exposures reviewed herein included lead, cadmium, mercury, arsenic, fluoride, aflatoxin, melamine, environmental tobacco, bisphenol A, dental procedures, phthalates, ferfluorooctanoic acid, triclosan, and thallium/uranium. Most studies assessed environmental chemical exposure via biomarkers but four studies assessed exposure via proximity to emission source. There was mixed evidence of association between metal exposures, and other non-metal environmental exposures and pediatric kidney disease and other kidney disease biomarkers. The evaluation of causality is hampered by the small numbers of studies for each type of environmental exposure, as well as lack of study quality and limited prospective evidence. Conclusion There is a need for well-designed epidemiologic studies of environmental chemical exposures and kidney disease outcomes.

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“…Furthermore due to the complex nature of PAHs, high content excreted in urine can be associated with recent exposure, while low excretion is assigned to low exposure or decreased ability to detoxify a particular PAHs compounds [36]. However, high levels of urine PAH were also reported for adolescents aged 12-19 years following National Health and Nutrition Ex- EAHT amination Survey (NHANES) [37]. Abiodun et al, showed that PAHs pollution was more in Asia and Africa than elsewhere in the world [38].…”

Section: Eahtmentioning

confidence: 99%

Biomonitoring of concentrations of polycyclic aromatic hydrocarbons in blood and urine of children at playgrounds within Owerri, Imo State, Nigeria

Wirnkor

Ngozi

Ajero

et al. 2019

Environ Anal Health Toxicol

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Polycyclic aromatic hydrocarbons (PAHs) exposure is among the leading air pollutants associated with diverse adverse health effects due to their persistent, bio-accumulative and toxic characteristics. Children are most affected by these pollutants, yet studies directly related children to these pollutants are scarce in Nigeria. In this study, blood and urine from 36 children between the ages 4-14 years were collected as per sterile procedures by a licensed phlebotomist from the antecubital fossa into BD vacutainer tubes® while a mid-stream urine sample into acid-washed 120 mL BD vacutainer urine cups and stored in refrigerator at –4˚C for 6 hours, then each 5 mL was extracted with 10 mL of pentane and analyzed for 15 PAHs using GC-MS. Results revealed that PAHs concentrations (53.48 to 70.8 μg/dL) in blood was lower than in urine (94.98 to 115.04 μg/dL). Mean values had no significant (p>0.5) differences between schools, possibly due to the fact that all schools were experiencing similar anthropogenic disturbances. At 5% level of significance, positive and strong correlationships (r=0.83, r=0.73) were observed for fluorene-fluoranthene (FLa) and benzo (a) anthracene-FLa respectively in blood samples. Two and three rings PAHs had generally low concentrations in both blood and urine. Despite being the most distributed compound, the concentration of dibenzo (a,h) anthracene was highest for urine than in blood. Urine PAHs showed higher concentration of carcinogenic PAHs than blood. Elimination ratios (ER) such as for acenaphthene (0.06) and anthracene (Ant; 0.11) were considered low while values such as for FLa (1.36) and indeno [1, 2, 3-cd] pyrene (1.55) were considered high ER. Trends in elimination ratios showed close similarity. In conclusion there was elevated PAHs in blood and urine of children with consequent high carcinogenic and then non-carcinogenic risks. This research is significant in setting the stage for more detailed work at same time alerting policy makers on the need for urgent mitigation steps that will reduce children exposure to this class of dangerous pollutants.

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Urinary polycyclic aromatic hydrocarbons and measures of oxidative stress, inflammation and renal function in adolescents: NHANES 2003–2008

Cited by 104 publications

References 79 publications

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Urinary Polycyclic Aromatic Hydrocarbon Metabolite Associations with Biomarkers of Inflammation, Angiogenesis, and Oxidative Stress in Pregnant Women

Environmental exposures and pediatric kidney function and disease: A systematic review

Biomonitoring of concentrations of polycyclic aromatic hydrocarbons in blood and urine of children at playgrounds within Owerri, Imo State, Nigeria

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