Urinary spermine level as novel additional diagnostic marker of prostate cancer

Bentrad, Veronika; Gogol, S.; Zaletok, S.; Vitruk, Yurii V.; Stakhovskyi, E. O.; Grechko, Boghdan O.

doi:10.1093/annonc/mdz343.023

Cited by 4 publications

(3 citation statements)

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“…In this regard, spermine is a polyamine involved in cellular metabolism, having ornithine AA as a precursor. Our findings regarding decreased levels of L-proline in PCa patients' plasma samples vs. healthy controls are consistent with other literature findings, as Bentrad et al (2019) described that the concentration of spermine was 7-34 times lower in PCa samples when compared to healthy individuals and even to patients with benign prostate hyperplasia [22]. In contrast, one study proposed spermine (among other metabolites) as a potential biomarker in distinguishing aggressive from indolent PCa, as spermine levels were decreased in the aggressive phenotype [23].…”

Section: Discussionsupporting

confidence: 93%

Potential Diagnostic Biomarker Detection for Prostate Cancer Using Untargeted and Targeted Metabolomic Profiling

Nițușcă

Socaciu

et al. 2023

CIMB

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Prostate cancer (PCa) remains one of the leading causes of cancer mortality in men worldwide, currently lacking specific, early detection and staging biomarkers. In this regard, modern research focuses efforts on the discovery of novel molecules that could represent potential future non-invasive biomarkers for the diagnosis of PCa, as well as therapeutic targets. Mounting evidence shows that cancer cells express an altered metabolism in their early stages, making metabolomics a promising tool for the discovery of altered pathways and potential biomarker molecules. In this study, we first performed untargeted metabolomic profiling on 48 PCa plasma samples and 23 healthy controls using ultra-high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-[ESI+]-MS) for the discovery of metabolites with altered profiles. Secondly, we selected five molecules (L-proline, L-tryptophan, acetylcarnitine, lysophosphatidylcholine C18:2 and spermine) for the downstream targeted metabolomics and found out that all the molecules, regardless of the PCa stage, were decreased in the PCa plasma samples when compared to the controls, making them potential biomarkers for PCa detection. Moreover, spermine, acetylcarnitine and L-tryptophan had very high diagnostic accuracy, with AUC values of 0.992, 0.923 and 0.981, respectively. Consistent with other literature findings, these altered metabolites could represent future specific and non-invasive candidate biomarkers for PCa detection, which opens novel horizons in the field of metabolomics.

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Section: Discussionsupporting

confidence: 93%

Potential Diagnostic Biomarker Detection for Prostate Cancer Using Untargeted and Targeted Metabolomic Profiling

Nițușcă

Socaciu

et al. 2023

CIMB

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“…Results indicated that normalized urinary spermine level was significantly lower in cancerous conditions than both BPH and healthy conditions [9]. Similar study with HPLC technique also revealed spermine levels in PCa patients were lowered by 7-34 times in comparison with healthy men and lower by 5-13 times than in patients with BPH as well as in peripheral blood [23]. Serkova et al has also assessed the role of polyamines in human expressed prostatic secretions by proton nuclear magnetic resonance spectroscopy.…”

Section: Urological Cancersmentioning

confidence: 84%

The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies

Tse

Wong

Chiu

et al. 2022

IJMS

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Polyamines are essential biomolecules for normal cellular metabolism in humans. The roles of polyamines in cancer development have been widely discussed in recent years. Among all, spermine alongside with its acetylated derivative, N1, N12-diacetylspermine, demonstrate a relationship with the diagnosis and staging of various cancers, including lung, breast, liver, colorectal and urogenital. Numerous studies have reported the level of spermine in different body fluids and organ tissues in patients with different types of cancers. Currently, the role and the underlying mechanisms of spermine in cancer development and progression are still under investigation. This review summarized the roles of spermine in cancer development and as a diagnostic, prognostic and therapeutic tool in various cancers.

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“…A step toward an applicable urine test for spermine, which functions as a tumor marker, − has been made by the Kim group, establishing analyte-directed formation of emissive excimers in the presence of polyamines, particularly spermine . The emission turn-on probe ( C3.3 in Figure ) was operational in 10 mM HEPES, pH 7.4, and in artificial urine.…”

Section: Amines (Other Than Amino Acids)mentioning

confidence: 99%

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

et al. 2022

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Synthetic molecular probes, chemosensors, and nanosensors used in combination with innovative assay protocols hold great potential for the development of robust, low-cost, and fast-responding sensors that are applicable in biofluids (urine, blood, and saliva). Particularly, the development of sensors for metabolites, neurotransmitters, drugs, and inorganic ions is highly desirable due to a lack of suitable biosensors. In addition, the monitoring and analysis of metabolic and signaling networks in cells and organisms by optical probes and chemosensors is becoming increasingly important in molecular biology and medicine. Thus, new perspectives for personalized diagnostics, theranostics, and biochemical/ medical research will be unlocked when standing limitations of artificial binders and receptors are overcome. In this review, we survey synthetic sensing systems that have promising (future) application potential for the detection of small molecules, cations, and anions in aqueous media and biofluids. Special attention was given to sensing systems that provide a readily measurable optical signal through dynamic covalent chemistry, supramolecular host− guest interactions, or nanoparticles featuring plasmonic effects. This review shall also enable the reader to evaluate the current performance of molecular probes, chemosensors, and nanosensors in terms of sensitivity and selectivity with respect to practical requirement, and thereby inspiring new ideas for the development of further advanced systems.

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Urinary spermine level as novel additional diagnostic marker of prostate cancer

Cited by 4 publications

References 0 publications

Potential Diagnostic Biomarker Detection for Prostate Cancer Using Untargeted and Targeted Metabolomic Profiling

Potential Diagnostic Biomarker Detection for Prostate Cancer Using Untargeted and Targeted Metabolomic Profiling

The Potential Role of Spermine and Its Acetylated Derivative in Human Malignancies

Molecular Probes, Chemosensors, and Nanosensors for Optical Detection of Biorelevant Molecules and Ions in Aqueous Media and Biofluids

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