Urinary Tract Infections

Gatermann, Sören; Crossley, Kent

doi:10.1002/9781444308464.ch24

Cited by 3 publications

(5 citation statements)

References 156 publications

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“…Urease is encoded by the ureABCDERGD operon, and the resulting multisubunit enzyme is known to function as the major virulence factor during urinary tract infection with CoNS such as Staphylococcus saprophyticus . Efficient urease production in ATCC12228 and RP62A could reflect their lifestyles on human skin or on indwelled medical devices, where they encounter urea as a part of body fluids. In our recent exoproteome study, we have shown that RP62A and ATCC12228 are more efficient in hydrolyzing urea compared to that of PM221 .…”

Section: Resultsmentioning

confidence: 99%

Genomics and Proteomics Provide New Insight into the Commensal and Pathogenic Lifestyles of Bovine- and Human-Associated Staphylococcus epidermidis Strains

Savijoki¹,

Iivanainen²,

Siljamäki³

et al. 2014

J. Proteome Res.

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The present study reports comparative genomics and proteomics of Staphylococcus epidermidis (SE) strains isolated from bovine intramammary infection (PM221) and human hosts (ATCC12228 and RP62A). Genome-level profiling and protein expression analyses revealed that the bovine strain and the mildly infectious ATCC12228 strain are highly similar. Their genomes share high sequence identity and synteny, and both were predicted to encode the commensal-associated fdr marker gene. In contrast, PM221 was judged to differ from the sepsis-associated virulent human RP62A strain on the basis of distinct protein expression patterns and overall lack of genome synteny. The 2D DIGE and phenotypic analyses suggest that PM221 and ATCC12228 coordinate the TCA cycle activity and the formation of small colony variants in a way that could result in increased viability. Pilot experimental infection studies indicated that although ATCC12228 was able to infect a bovine host, the PM221 strain caused more severe clinical signs. Further investigation revealed strain- and condition-specific differences among surface bound proteins with likely roles in adhesion, biofilm formation, and immunomodulatory functions. Thus, our findings revealed a close link between the bovine and commensal-type human strains and suggest that humans could act as a reservoir of bovine mastitis-causing SE strains.

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Section: Resultsmentioning

confidence: 99%

Genomics and Proteomics Provide New Insight into the Commensal and Pathogenic Lifestyles of Bovine- and Human-Associated Staphylococcus epidermidis Strains

Savijoki¹,

Iivanainen²,

Siljamäki³

et al. 2014

J. Proteome Res.

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“…Infections due to S. saprophyticus usually peak during late summer and fall, a pattern similar to that of sexually transmitted diseases (54,55). A number of risk factors have been identified, including recent sexual intercourse, outdoor swimming, and occupational meat processing (54). Several virulence factors have been proposed, including a surface-exposed 160-kDa hemagglutinin/adhesin, which is expressed preferably under anaerobic conditions and binds surface-exposed fibronectin on uroepithelial cells; this might explain the tropism for kidney colonization of S. saprophyticus (24).…”

Section: Urinary Tract Infectionmentioning

confidence: 91%

“…If the organism is susceptible to well-absorbed oral antibiotics, therapy can sometimes be completed by the oral route once the infection has been controlled and the foreign material removed. In contrast, UTI caused by S. saprophyticus usually can be treated orally with any of the antibiotics most commonly used against urinary pathogens (54).…”

Section: Endophthalmitismentioning

confidence: 98%

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Coagulase-Negative Staphylococci: Role as Pathogens

1999

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Coagulase-negative staphylococci have long been regarded as apathogenic but their important role as pathogens and their increasing incidence have been recognized and studied in recent years. Although specific virulence factors are not as clearly established as they are in Staphylococcus aureus, it seems clear that factors such as bacterial polysaccharide components are involved in attachment and/or persistence of bacteria on foreign materials. Coagulase-negative staphylococci are by far the most common cause of bacteremia related to indwelling devices. Most of these infections are hospital-acquired, and studies over the past several years suggest that they are often caused by strains that are transmitted among hospitalized patients. Other important infections due to coagulase-negative staphylococci include central nervous system shunt infections, native or prosthetic valve endocarditis, urinary tract infections, and endophthalmitis. Intravenous treatment of systemic infections is usually required because coagulase-negative staphylococci have become increasingly resistant to multiple antibiotics.

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“…Catheters are put in the focal line to give liquids and drugs, yet delayed use can cause genuine diseases in the circulation system, jeopardizing wellbeing and expanding the expense of care [9]. Despite the fact that there is is a 46% discount in CLABSI from 2008 -2013 in American clinics, an expected 30,100 CLABSI still happen in the emergency unit intense office offices in the United States every year [10] .…”

Section: Materials and Methods Central Line-associated Bloodstream In...mentioning

confidence: 99%

Study Physiology and Immunology Emergency Clinic Diseases in Patients Experiencing Clinical Consideration and Contamination.

Ibrahim¹

2023

IJMRA

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Emergency clinic diseases or medicinal services related contaminations happen in patients experiencing clinical consideration. This contamination happens worldwide in both created and creating nations. Generally, Staph, Streptococcus, an d Escherichia coli have been triple clinic diseases. Emergency clinic pneumonia, careful injury contaminations, and vascular-related septicemia made access most illnesses and passings in medical clinic patients; concentrated consideration units were the foca l point of anti-infection obstruction. The procured antimicrobial opposition is the primary issue, and the obstruction of Staphylococcus aureus is the greatest concern. The move to outpatient care departs the most powerless patients in medical clinics, with emergency clinic disease representing 7% in created nations and 10% in creating nations. Since this disease happens duri ng medical clinic remain, it causes delayed remain, incapacity and financial weight. Visit diseases incorporate focal line circulato ry system contaminations, urinary tract diseases related with a catheter, careful site contaminations and ventilation-related pneumonia. Clinic pathogens incorporate microscopic organisms, infections, and contagious parasites. As indicated by WHO gauges, almost 15% of all patients endure in medical clinics these contaminations. During hospitalization, the patient is presented to pathogens through an alternate asset condition, human services work force, and other contaminated patients.

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Urinary Tract Infections

Cited by 3 publications

References 156 publications

Genomics and Proteomics Provide New Insight into the Commensal and Pathogenic Lifestyles of Bovine- and Human-Associated Staphylococcus epidermidis Strains

Genomics and Proteomics Provide New Insight into the Commensal and Pathogenic Lifestyles of Bovine- and Human-Associated Staphylococcus epidermidis Strains

Coagulase-Negative Staphylococci: Role as Pathogens

Study Physiology and Immunology Emergency Clinic Diseases in Patients Experiencing Clinical Consideration and Contamination.

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