Urinary transferrin pre-emptively identifies the risk of renal damage posed by subclinical tubular alterations

Casanova, Alfredo G.; Vicente-Vicente, Laura; Hernández-Sánchez, María Teresa; Prieto, Marta; Rihuete, María; Ramis, Laura; Barco, Elvira del; Cruz, Juan Jesús; Ortíz, Alberto; Cruz-González, Ignacio; Martı́nez-Salgado, Carlos; Pescador, Moisés; López‐Hernández, Francisco J.; Morales, Ana Isabel

doi:10.1016/j.biopha.2019.109684

Cited by 28 publications

(27 citation statements)

References 53 publications

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“…Prior sepsis studies supported the use of urine samples as biomarkers for therapeutic and immunological monitoring 10 – 17 . Therefore, collecting urine samples for immune system monitoring may be an appealing alternative over blood sample collection, especially considering that many patients with COVID-19 infections receive treatment at home and blood draw can be challanging 18 , 19 . While the literature indicates a correlation between these two compartments, it is not a uniform finding across the different research studies and are mainly focused on nucleic acid signatures 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure

Laudański

Okeke

Hajj

et al. 2021

Sci Rep

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Kidney function is affected in COVID-19, while kidney itself modulates the immune response. Here, hypothesize if COVID-19 urine biomarkers level can assess immune activation vs. clinical trajectory. Considering the kidney’s critical role in modulating the immune response, we sought to analyze activation markers in patients with pre-existing dysfunction. This was a cross-sectional study of 68 patients. Blood and urine were collected within 48 h of hospital admission (H1), followed by 96 h (H2), seven days (H3), and up to 25 days (H4) from admission. Serum level ferritin, procalcitonin, IL-6 assessed immune activation overall, while the response to viral burden was gauged with serum level of spike protein and αspike IgM and IgG. 39 markers correlated highly between urine and blood. Age and race, and to a lesser extend gender, differentiated several urine markers. The burden of pre-existing conditions correlated with urine DCN, CAIX and PTN, but inversely with IL-5 or MCP-4. Higher urinary IL-12 and lower CAIX, CCL23, IL-15, IL-18, MCP-1, MCP-3, MUC-16, PD-L1, TNFRS12A, and TNFRS21 signified non-survivors. APACHE correlated with urine TNFRS12, PGF, CAIX, DCN, CXCL6, and EGF. Admission urine LAG-3 and IL-2 predicted death. Pre-existing kidney disease had a unique pattern of urinary inflammatory markers. Acute kidney injury was associated, and to a certain degree, predicted by IFNg, TWEAK, MMP7, and MUC-16. Remdesavir had a more profound effect on the urine biomarkers than steroids. Urinary biomarkers correlated with clinical status, kidney function, markers of the immune system activation, and probability of demise in COVID-19.

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Section: Introductionmentioning

confidence: 99%

Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure

Laudański

Okeke

Hajj

et al. 2021

Sci Rep

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“…It has been proven that they are metabolic components or derivatives, degradation compounds or remnants of them that appear in the urine as a result of damage to kidney structures [ 36 , 37 , 38 , 39 ]. In this study we have identified different urinary biomarkers (protein, albumin, transferrin, KIM-1, NAG and NGAL), which are related to a subclinical tubular alteration [ 40 , 41 , 42 ]. The importance of this finding is that repeated tubular damage could progress to chronic kidney disease [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides

Martín-Reina

Casanova

Dahiri

et al. 2021

IJERPH

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Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase and butyrylcholinesterase activities are considered as biomarkers of pesticides poisoning. However, biomarkers of oxidative stress are also playing an important role in toxicity of these contaminants. Further, increased activities of gamma-glutamyltransferase, alanine aminotransferase, urea and creatinine have been linked with hepatic and nephrotoxic cell damage, respectively. The aim of this study was to ascertain if the indirect exposure to pesticides leads to some biochemical parameter changes. Thus, cholinesterase activities, oxidative stress status (lipid and protein oxidation), hepatic function (AST and ALT levels), hormonal function (TSH, T4, FSH, LH and AMH), renal function (serum creatinine and urea), as well as possible subclinical kidney damage (urinary proteins and biomarkers of early kidney damage) were evaluated in farmer women who collect fruits and vegetables comparing with a group of women non-occupational exposed to pesticides but living in the same rural environment. Samples were taken periodically along one year to relate the observed effects to a chronic exposure. Our main results showed for the first time a subclinical kidney damage in a rural setting with indirect chronic exposure to pesticides.

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“…vascular, haemodynamic). [20] The combination of [TIMP-2]*[IGFBP7], urinary markers of G1 cell cycle arrest, improve the identi cation of patients at risk for imminent AKI, [38] [39] and the decline in their urinary values is a valid predictor for renal recovery. [40] The exact mechanism by which IGFBP7 and TIMP-2 levels increase in the urine in different AKI models is not completely known, although increased ltration, proximal tubular cell leakage and defects in tubular reabsorption are the most likely mechanisms.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Subclinical Sequelae of acute Kidney Injury Predispose To Acute Kidney Injury In Rats: Diagnostic Biomarkers

Fuentes‐Calvo¹,

Cuesta²,

Sancho-Martínez³

et al. 2021

Preprint

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Background. Acute kidney injury (AKI) is a risk factor for new AKI episodes and progression to chronic kidney disease, cardiovascular events and death, as under certain circumstances renal repair is maladaptive leading to proinflammatory and profibrotic signals. The definition for AKI recovery is based on increases in plasma creatinine, but it only happens when 50-70 % of nephrons have been lost. There are no studies monitoring the real state of structural and functional recovery after an AKI episode. We analysed the functional and structural sequelae after an episode of AKI in rats, whether and for how long animals retain enhanced sensibility to AKI and whether such a condition may be detected by known biomarkers of subclinical renal damage.Methods. We performed a cisplatin (5mg/kg body weight)-induced AKI in rats and, after recovery, we studied the renal susceptibility to new AKI episodes after treatment with subtoxic doses of gentamicin (50 mg/kg).Results. One week after the recuperation of a cisplatin-induced AKI, the kidneys show histological alterations (cast formation, necrosis and tubular dilatation), and predisposition to new AKI episodes after subtoxic gentamicin treatment. Tubular function (urine output and urinary excretion of K+, assessed by the furosemide tubular function test) remains affected despite the recovery of renal filtration after the AKI episode. Several urinary biomarkers detect this subclinical damage: albumin, transferrin, insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2). The increased [TIMP-2]*[IGFBP7] urinary excretion predicts new AKI episodes before gentamicin subtoxic treatment.Conclusions. After a cisplatin-induced AKI, the kidneys are in functional risk for new AKI episodes, which can be prevented by monitoring IGFBP7 and TIMP-2 urinary excretion. Our findings require subsequent clinical validation to verify the potential of these biomarkers in predicting future episodes of kidney damage.

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Urinary transferrin pre-emptively identifies the risk of renal damage posed by subclinical tubular alterations

Cited by 28 publications

References 53 publications

Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure

Longitudinal urinary biomarkers of immunological activation in covid-19 patients without clinically apparent kidney disease versus acute and chronic failure

Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides

WITHDRAWN: Subclinical Sequelae of acute Kidney Injury Predispose To Acute Kidney Injury In Rats: Diagnostic Biomarkers

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