Urinary Trypsinogen-2 Dipstick in Acute Pancreatitis

Abstract

Objectives To determine the frequency of raised Urinary Trypsinogen-2 in diagnosed patients of acute pancreatitis. Methodology Settings Patients in emergency refer to General Surgery ward-3 Jinnah Post Graduate and Medical Centre Karachi. Duration Six months, started from 20-01-2012 to 19-07-2012. Study Design Cross sectional descriptive study. Subjects and Methods All cases of Acute Pancreatitis diagnosed by Upper Abdominal Pain, Raised Serum Amylase and/or Serum Lipase and Abdominal CT Scan findings, were included in the study. Urinary Trypsinogen-2 dipstick test was done. All patient related data including age, gender, sex and raised Urinary Trypsinogen-2 or normal, was recorded. Data analysis was done on SPSS version 10. Frequency and percentage was calculated for gender and raised trypsinogen-2. Age and gender wise stratification was done to see the effect of these variables on outcome. Results Mean age of the patients was 38.14 ±7.42 years. The minimum age was 24 years, while the maximum age was 63 years. Raised urinary trypsinogen-2 level was present in 55 (65.5%) patients. Stratification of age group shows, that 40 (66.7%) patients in age group ≤ 40 years had raised urinary trypsinogen-2. Stratification of gender showed significant association with raised urinary trypsinogen-2 level (p-value 0.010). Conclusion The frequency of raised Urinary Trypsinogen-2 in diagnosed patients of acute pancreatitis was found to be high.

Urinary amylase / urinary creatinine ratio (uAm/uCr) - a less-invasive parameter for management of hyperamylasemia

“…In particular, the serum level of lipase is a comparable marker of pancreatic disease, but rapid and cost-effective measurement systems are not broadly available [1-3]. Urinary trypsinogen-2 strip test has also drawn attention recently for early detection of pancreatitis, but is not quantitative and less sensitive [23,24]. Therefore, sAm has some issues concerning its use, but has been used broadly as practical marker of pancreatic disorders.…”

What Have We Learned About Acute Pancreatitis in Children?

“…Newer tests such as serum or urine measurement of trypsinogen activation peptide have not been examined in children (27,28). …”

“…Additional biochemical parameters to diagnose acute pancreatitis include the serum cationic trypsinogen, which was shown by Weizman and Durie (18) to have greater sensitivity than amylase. Newer tests such as serum or urine measurement of trypsinogen activation peptide have not been examined in children (27,28).…”

Pancreatitis aguda

“…Se han desarrollado tests para determinación rápida de tripsinógeno urinario. Al parecer, si bien su realización es de fácil implementación, los resultados de sensibilidad y especificidad son contradictorios en las distintas publicaciones, (95) (96) por lo que su uso no se ha generalizado.…”