Urine Multi-drug Screening with GC-MS or LC–MS-MS Using SALLE-hybrid PPT/SPE

Lee, Jun Hui; Park, Ji Won; Go, Ahra; Moon, Hee-Sung; Kim, Sujin; Jung, Sua; Jeong, Wonjoon; Chung, Heesun

doi:10.1093/jat/bky032

Cited by 21 publications

(17 citation statements)

References 21 publications

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“…Metabolites of kratom will not appear on a standard urine toxicology. Standard analytical screening techniques for mitragynine and its metabolites, as with other NPS, require a more sophisticated liquid chromatography-mass spectrometry [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Outcomes of mothers and newborns to prenatal exposure to kratom: a systematic review

et al. 2021

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Kratom is a legal, widely available substance that contains opioid agonist alkaloids. Due to the marketing of kratom as an opioid alternative for treatment of pain, anxiety, depression, or to reduce opioid withdrawal symptoms, the use of kratom has increased among persons in the USA including pregnant women. This systematic review of the peer-reviewed literature regarding kratom in relation to maternal and infant outcomes resulted in analysis of six case reports of prenatal kratom exposure. Maternal and infant withdrawal from kratom exposure was described in each case, resulting in pharmacologic treatment for both mothers and infants.

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Section: Introductionmentioning

confidence: 99%

Outcomes of mothers and newborns to prenatal exposure to kratom: a systematic review

et al. 2021

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“…In addition to the increased practical application of MALDI-TOF MS, the combination of electrospray ionization (ESI) and liquid chromatography–mass spectrometry (LC-MS/MS) is becoming popular as a rapid quantitative technique for low molecular weight compounds. LC-MS/MS is an essential tool for analyzing medicinal toxicants and therapeutic drug monitoring in forensic medicine [ 83 , 84 ]. The extent of the scientific literature relating to bacterial ID using LC-MS/MS has also gradually increased [ 85 , 86 , 87 , 88 ].…”

Section: Application Of Liquid Chromatography–mass Spectrometry Fomentioning

confidence: 99%

Current Status of Matrix-Assisted Laser Desorption/Ionization–Time-of-Flight Mass Spectrometry (MALDI-TOF MS) in Clinical Diagnostic Microbiology

2020

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Mass spectrometry (MS), a core technology for proteomics and metabolomics, is currently being developed for clinical applications. The identification of microorganisms in clinical samples using matrix-assisted laser desorption/ionization–time-of-flight mass spectrometry (MALDI-TOF MS) is a representative MS-based proteomics application that is relevant to daily clinical practice. This technology has the advantages of convenience, speed, and accuracy when compared with conventional biochemical methods. MALDI-TOF MS can shorten the time used for microbial identification by about 1 day in routine workflows. Sample preparation from microbial colonies has been improved, increasing the accuracy and speed of identification. MALDI-TOF MS is also used for testing blood, cerebrospinal fluid, and urine, because it can directly identify the microorganisms in these liquid samples without prior culture or subculture. Thus, MALDI-TOF MS has the potential to improve patient prognosis and decrease the length of hospitalization and is therefore currently considered an essential tool in clinical microbiology. Furthermore, MALDI-TOF MS is currently being combined with other technologies, such as flow cytometry, to expand the scope of clinical applications.

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“…Coupling of thinlayer chromatography (TLC) and SERS should also be propitious for on-site detection considering the simple, rapid, highsensitivity approach. 244 TLC has significant advantages over other commonly used techniques like gas chromatographymass spectrometry (GC-MS) 245,246 and liquid chromatography-mass spectrometry (LC-MS). 247,248 Since first reported by Hezel, 249 the TLC-SERS approach has been applied in the detection of various analytes, including biomarkers in biological samples.…”

Section: Sers-based Methods For Bacterial Infection and Disease Diagnosismentioning

confidence: 99%

Surface-enhanced Raman spectroscopy for bioanalysis and diagnosis

et al. 2021

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Urine Multi-drug Screening with GC-MS or LC–MS-MS Using SALLE-hybrid PPT/SPE

Cited by 21 publications

References 21 publications

Outcomes of mothers and newborns to prenatal exposure to kratom: a systematic review

Outcomes of mothers and newborns to prenatal exposure to kratom: a systematic review

Current Status of Matrix-Assisted Laser Desorption/Ionization–Time-of-Flight Mass Spectrometry (MALDI-TOF MS) in Clinical Diagnostic Microbiology

Surface-enhanced Raman spectroscopy for bioanalysis and diagnosis

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