Urine Routine Test has Potential Predictive Value in Premature Rupture of the Membranes

Abstract

Background: This study was conducted to discuss predictive value of a routine urine test for premature rupture of the membranes(PROM).Methods: We carried out the retrospective research after collecting routine urine test data from 45 cases of full preterm premature rupture of membranes (PPROM) and 45 cases of full-term preterm premature rupture of membranes (fPROM). In addition 70 healthy pregnant women (Normal) and 70 non-pregnant adult healthy women were enrolled. Parametric and Non-parametric tests was performed respectively. The receiver operating characteristic (ROC) was established and we further calculated the area under the ROC curve (AUC). In this study multiple cutoffs were selected, afterwords the positive predictive value (PPV), the negative predictive value (NPV), the positive likelihood ratio (+LR) and negative likelihood ratio (-LR) were further calculated by sensitivity and specificity with the aim of finding the best cutoff point.Results: The results indicated that S/G and COND were significantly different between PROM and Non-pregnant and Normal groups. Significant differences in pH, WBCs, RBCs, BAC and EC between the PPROM and Normal groups were observed. When the cutoff for bacteria was 89.15, it had the largest AUC of 0.744. We found that its PPV 70.6%, NPV was 74.1%, +LR was 3.79, and –LR was 0.55.Conclusion: A routine urine test especially for bacterial counts can be used to predict the risk of PROM, which is expected to provide considerable predictive value for PROM.