Urine Saturation and the Formation of Calcium-containing Renal Calculi: The Effects of Various Forms of Therapy

Marshall, R. W.; Barry, Hugh C.

doi:10.1159/000394935

Cited by 5 publications

(5 citation statements)

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“…This addition ally absorbed oxalate finally appears in the urine. Reduction of the calcium/oxalate ratio in the diet [18] or binding of calcium in the intestine by administration of ionexchangers such as cellulose phosphate [10,19] have a simi lar effect on oxalate absorption and excretion in the urine. In the light of the observations in this paper it is difficult to understand how treatment with cellulose phosphate will benefit the calcium oxalate stone-former, as suggested by some workers [5,23,24,31].…”

Section: The Mechanism By Which Mild Hyperoxaluria Increases the Riskmentioning

confidence: 99%

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

Robertson

Peacock²

1980

Nephron

270

118

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Hypercalciuria is common in patients who form calcium oxalate urinary stones and is considered by many to be the cause ofthe disorder. This review shows that there is little relationship between either the rate of stone-formation or calcium oxalate crystalluria and the urinary excretion of calcium. There is, however, a strong relationship between these parameters and the urinary excretion of oxalate which is slightly, but significantly, elevated in stone-formers compared with normals. It is concluded that this mild degree of hyperoxaluria may be much more important than hypercalciuria in the genesis of calcium oxalate stones.

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Section: The Mechanism By Which Mild Hyperoxaluria Increases the Riskmentioning

confidence: 99%

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

Robertson

Peacock²

1980

Nephron

270

118

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“…This rise in oxalate crystals on thiazide treatment is not easy to explain and may indeed be not statistically significant. It is worth noting, however, that both Marshall and Barry (1973) and Hallson, Kasidas and Rose (1977) both noted a small but not statistically significant rise in urinary oxalate with thiazide treatment suggesting that this rise might in fact be real and be responsible for the similar rise in oxalate crystal incidence.…”

mentioning

confidence: 94%

“…However, the changes produced in urine composition by the drugs used to lower urinary calcium are rather complex. For example, it has been shown that cellulose phosphate dramatically raises urinary oxalate (Marshall and Barry, 1973;Hallson, Kasidas and Rose, 1977) and lowers urinary magnesium (Dent, Harper and Parfitt, 1964;Teotia et al, 1974) while thiazides have been shown to lower urinary citrate (Garcia and Yendt, 1970). It is therefore difficult to know whether the treatments used in fact lead to an increase or decrease in saturation of urine with regard to calcium oxalate and phosphate.…”

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confidence: 99%

Crystalluria in Normal Subjects and in Stone Formers With and Without Thiazide and Cellulose Phosphate Treatment

Hallson

Rose

1976

British Journal of Urology

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Quantitative and qualitative studies have been made of the urinary crystals from a series of normal subjects and from stone formers with idiopathic hypercalciuria with and without treatment with thiazide diuretics and/or cellulose phosphate. The results obtained from mid-morning unprepared subjects seemed more helpful than those obtained following overnight collections or after a dry breakfast. Crystalluria was more common in stone formers than in normal subjects, but was seen in both groups. The most striking difference between these 2 groups was the almost complete absence of aggregation of oxalate crystals in the normal subjects. Cellulose phosphate greatly reduced phosphate crystals but resulted in a large increase in small oxalate crystals but without change in the incidence of aggregation of oxalate crystals. Thiazides also reduced occurrence of phosphate crystals but only gave a very small increase in oxalate crystals and also without change in aggregation of oxalate crystals.

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“…Similar studies of complex chemistry using urine ionic equilibrium programs have been carried out by ELLIOT (1973), MARSHALL and BARRY (1973), GILL (1974), ACHILLES et al (1976), ERWIN et al (1976), TISELIUS et al (1978), BRUNDIG et al (1980, DANIELS andMARANGELLA (1981), HARTUNG et al (1981), RAPADO et al (1981), MATOUSCHEK and HUBER (1982), TISELIUS andLARSSON (1982), VOGEL et al (1984), BAUMANN et al (1985) and ACHILLES and ULSHOEFER (1985). attempted to reduce the number of measurements required by estimating the calcium oxalate, octacalcium phosphate and magnesium ammonium phosphate activity products.…”

Section: ) Urine Studiesmentioning

confidence: 67%

Diagnosis of Urinary Calculi

Vahlensieck¹

1985

Handbook of Urology

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Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest 50:21 Arnaud CD, Goldsmit RS, Bardier PJ, Sizemore GW (1974) Influence ofimmunoheterogenity of circulating parathyroid hormone on results of radioimmunoassay of serum in man. Am J Med 56:785 Arora B, Selby PL, Norman RW, Peacock M, Robertson WG (1985) The effect of an increased intake of various constituents of a high animal protein diet on the risk of calcium oxalate stone formation in men. In: Schwille PO, Smith LH, Robertson WG, Vahlensieck W (eds) Urolithiasis and realted clinical research. Plenum Press, New York London, p 85

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Urine Saturation and the Formation of Calcium-containing Renal Calculi: The Effects of Various Forms of Therapy

Cited by 5 publications

References 0 publications

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

The Cause of Idiopathic Calcium Stone Disease: Hypercalciuria or Hyperoxaluria?

Crystalluria in Normal Subjects and in Stone Formers With and Without Thiazide and Cellulose Phosphate Treatment

Diagnosis of Urinary Calculi

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