Uritica dioica improves brain dysfunctions in propionic acid autistic like rat model through brain monoamines and mitochondrial energy

Ali, Elham H.A.; Hassan, Mohamed K.; Abbas, Osama A.; E.Elmalahy, Heba; Almaaty, Ali H. Abu

doi:10.21608/ajbs.2020.133010

Cited by 5 publications

(8 citation statements)

References 78 publications

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“…Propionic acid creates oxidative stress in PC12 that leads to mitochondria malfunction and can cause shutdown of citric acid cycle [77,78]. Our previous work we measured ATP, ADP, and AMP in the brain homogenate and a significant decline in bioenergetics was confirmed when compared to the control one [79].…”

Section: Mitochondrial Dysfunctionmentioning

confidence: 92%

“…The results showed that nettle leaves had poor effect on brain monoamines, bioenergetics, and behaviour improvement. While the roots showed a great effect on brain monoamines, bioenergetics, and behaviour [79]. Risperidone enhances monoamines system and behaviour.…”

Section: Supplements and Antioxidant Used To Ameliorate Or Prevent Th...mentioning

confidence: 94%

“…In the last 15 years, many behaviour tests were performed to evaluate propionic acid model features. The surprised one was social impairment to treated rats with each other and strangers [35,37,71,81,79,66]. Movement disorder specially stereotype behaviour, repetitive without proposed pattern.…”

Section: Behavior Similaritiesmentioning

confidence: 99%

“…In addition injected Wister rats weighing 115-125 g, a single dose of propionic acid(175 mg/kg, ip) for ultrastructure examination to amygdala and hippocampus [89,90]. Moreover, Wistar rats pups weighing 45-60g have been injected once daily 250 mg/kg ip for 17 consecutive days [79]. All these previous studies tried to produce an ASD animal model to get its research demand.…”

Section: Route Of Administration Of Ppa To Induce Animal Model Of Autismmentioning

confidence: 99%

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Is Propionic acid a suitable model for autism?

Elmalahy¹,

Ali

Almaaty

et al. 2021

Alfarama Journal of Basic & Applied Sciences

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Autism Spectrum Disorder (ASD) is defined as different degrees of disability in social interaction, stereotyped behavior, and altered motor and sensory perception. Many scientific research are concerned with making and developing animal models of autism to figure out the appropriate correlation between behavioural changes and the pathology of brain tissue to help in clinical trials of effective therapeutic formulations. Propionic acid can be present inside the cells as metabolite in a normal state and present in high amount in the gut due to some digestive disorders or alteration in gut microbiota. Moreover, it is considered an artificial food additive. Lately, propionic acid has become a controversy model. This review assessment demonstrates a complete picture and all the available information is needed to be known about the mechanism of action of the induced autistic model. It discusses the different methods explains the pathophysiology, and various treatment modalities were tried in the propionic induced animal model. It also enlists the developmental and behavioral aspects of the model animals

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Section: Mitochondrial Dysfunctionmentioning

confidence: 92%

Section: Supplements and Antioxidant Used To Ameliorate Or Prevent Th...mentioning

confidence: 94%

Section: Behavior Similaritiesmentioning

confidence: 99%

Section: Route Of Administration Of Ppa To Induce Animal Model Of Autismmentioning

confidence: 99%

See 2 more Smart Citations

Is Propionic acid a suitable model for autism?

Elmalahy¹,

Ali

Almaaty

et al. 2021

Alfarama Journal of Basic & Applied Sciences

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“…Group 2 (VPA -Control +): These include 8 male offspring of the mother group who received oral VPA Group 3 (VPA+ Moringa): These include 8 male offspring of the oral VPA mother group who were orally gavaged 400 mg/kg/day of the Moringa oleifera extract (Mohamed et al, 2019). Group 4 (VPA+Risperdone): These include 8 male offspring of the oral VPA mother group who were orally gavaged with 1gm/kg/day (Ali et al, 2020) Group 5 (VPA+Moringa+ Risperidone): These include 8 male offspring of the oral VPA mother group who received the MO and RIS with the dosage mentioned in the previous groups.…”

Section: -Experimental Designmentioning

confidence: 99%

Moringa oleifera improves liver and kidney functions in Valproic Acid autistic-like rat model

على

الشريف²,

خفاجى³

et al. 2023

مجلة البحوث البيئية والطاقة

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Autism is a neurological disease that affects social reciprocity and communication throughout life. Autism has been on the rise at an alarming rate over the last three decades, while the frequency appears to vary by country. The present study was designed to investigate the effect of Moringa oleifera leaves on sodium valproate (VPA) induced autistic-like rat model on the liver and kidney function and histopathology changes in rats compared with the synthetic drug risperidone. 40 pregnant females rats, 5 of them were used as control and the other 35 received a single oral dose of 800 mg/kg valproic acid (VPA) on the 11 th day of gestation then their offspring after weaning were randomly distributed into equal groups (n=8) and treated for 25 days as group 1: (Cont-) offspring of control mothers, (Cont+) VPA injection served as control positive, group 3: VPA+ moringa(400/mg/kg b. wt, p.o), group 4: VPA+ RIS (1 mg/kg b. wt, p.o), and group 5: VPA+ moringa + RIS. The rats were sacrificed at the end of the experiment and serum was used for the estimation of serum aspartate transaminase (AST), alanine transaminase (ALT), urea, and creatinine in addition to the histopathological study of the liver and brain. The results showed improvement in the weight, liver, and kidney function by moringa and/or risperidone treatment in comparison with VPA treated group. Therefore, it may be concluded that Moringa oleifera extract had a protective effect due to its impact on liver and kidney function.

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The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

Semwal,

Rauf,

Olatunde

et al. 2023

Nat. Prod. Bioprospect.

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Urtica dioica is a perennial herb from the family of Urticaceae that is commonly known as stinging nettle. This plant is widespread in Europe, Africa, America, and a part of Asia, as it adapts to different environments and climatic conditions. The leaves, stalk, and bark of U. dioica found applications in the field of nutrition, cosmetics, textile, pest control and pharmacology. In this connection, bioactive chemical constituents such as flavonoids, phenolic acids, amino acids, carotenoids, and fatty acids have been isolated from the plant. With this review, we aim at providing an updated and comprehensive overview of the contributions in literature reporting computational, in vitro, pre-clinical and clinical data supporting the therapeutic applications of U. dioica. Experimental evidence shows that U. dioica constituents and extracts can provide neuroprotective effects by acting through a combination of different molecular mechanisms, that are discussed in the review. These findings could lay the basis for the identification and design of more effective tools against neurodegenerative diseases. Graphical Abstract

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Uritica dioica improves brain dysfunctions in propionic acid autistic like rat model through brain monoamines and mitochondrial energy

Cited by 5 publications

References 78 publications

Is Propionic acid a suitable model for autism?

Is Propionic acid a suitable model for autism?

Moringa oleifera improves liver and kidney functions in Valproic Acid autistic-like rat model

The medicinal chemistry of Urtica dioica L.: from preliminary evidence to clinical studies supporting its neuroprotective activity

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