Urodynamic and Histological Changes in a Sterile Rabbit Vesicoureteral Reflux Model

Abstract

This study aimed to investigate pressure changes of renal pelvis and histological change of kidneys in a surgically induced sterile rabbit vesicoureteral reflux (VUR) model. Five rabbits served as a control group, 7 as the sham-operated group, and 8 served as the VUR group. Three weeks later, urodynamic studies were performed, and histological examinations evaluated degree of inflammation, fibrosis, and tubular damage in the kidneys. At a low infusion rate, renal pelvic pressure in the VUR group was stable until late filling phase and then increased slightly. At a high infusion rate, the renal pelvic pressures of the sham-operated and control groups were stable until late filling phase and then increased slightly, whereas the renal pelvic pressure in the VUR group steadily increased from mid filling phase. Focal thinning of the tubular epithelium and interstitial widening were observed in certain cortical areas of refluxing kidneys, without inflammatory cell infiltration. Obvious changes in the mean diameters of distal tubules and extracellular matrix volume fractions were observed in two highly refluxing kidneys. High pressure reflux with bladder instability may result in renal cortical changes.

The Biocompatibility of a Cellulose Exopolysaccharide Implant in the Rabbit Bladder When Compared With Dextranomer Microspheres Plus Hyaluronic Acid

“…1 Current treatment options for the treatment of this disease include prophylaxis (long term) with antibiotics to prevent pyelonephritis and await spontaneous resolution. However, high grades of reflux have a low rate of spontaneous resolution.…”

Simplified Bioprinting-Based 3D Cell Culture Infection Models for Virus Detection

“…The five cell lines used cover a large range of commonly used target cells for the cultivation of a broad spectrum of viruses and originate from different cell types, tissues, and species. The epithelial CRFK cells, which originate from the renal cortex, grew on Wellbricks in several layers in a cuboidal (upper layers) to squamous (lower layers) morphology, which can also be observed in the transitional epithelium of the renal pelvis [ 41 ]. In contrast, Vero cells, which also originate from the kidney, showed a cuboidal, single-layered cell growth typical of most of the kidney epithelium, e.g., for collecting ducts [ 42 ].…”

Validity of a disposable catheter to drain urine overnight in neurogenic bladder

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