Urological Pathology

Herbut, Peter A.

doi:10.1097/00007611-195209000-00030

Cited by 26 publications

(34 citation statements)

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“…In rats so pretreated the pattern of bladder disturbance resembles the clinical syndrome of an atonic neurogenic bladder (Herbut, 1952), which can be observed in neurological diseases affecting sensory nerves (as e.g. tabes dorsalis).…”

Section: Discussionmentioning

confidence: 85%

“…tabes dorsalis). Cystometric investigations in patients yielded no contractions of the bladder either during filling or when the bladder was full to capacity (Herbut, 1952). After sectioning of the sacral dorsal roots in cats a prolonged overdistension of the bladder occurs due to a lack of sensation, followed by atony with great volumes of residual urine and overflow (Barrington, 1914).…”

Section: Discussionmentioning

confidence: 96%

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Systemic capsaicin treatment impairs the micturition reflex in the rat

Holzer‐Petsche

Lembeck

1984

British J Pharmacology

125

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1 Filling the urinary bladder via a urethral cannula and preventing its voiding in anaesthetized rats led to rhythmic contractions of the detrusor muscle, which lasted for more than 1 h. This rhythmic activity ceased about 30 min after a s.c. injection of 50 mg kg-l capsaicin. The contractile response of the detrusor to topically applied capsaicin was lost after systemic administration of the toxin, whereas no change in the sensitivity to acetylcholine was observed. 2 Urinary bladders of normal rats had a capacity of about 1 ml. Bladders of rats treated with capsaicin as neonates held a volume of more than 5 ml without contracting. Such bladders were insensitive to topically applied capsaicin but they contracted to acetylcholine as strongly as the bladders of control rats. 3 During an observation period of 3 days control rats gained weight at night and lost weight by day. Rats treated with capsaicin as neonates showed little fluctuation in body weight. Such rats hardly excreted any urine by day although at night they excreted as much as controls. 4 A water load of 5 ml 100 g-l was excreted by control rats within 3 h. Rats treated with capsaicin as neonates excreted only half as much. In addition, 50% of the water load was excreted far later by capsaicin treated rats than by controls. Few changes were observed in rats treated with capsaicin as adults. 5 It is concluded that all primary afferent fibres mediating the sensation of a full bladder are capsaicin-sensitive. An additional effect of capsaicin on renal mechanisms cannot be excluded.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 96%

Systemic capsaicin treatment impairs the micturition reflex in the rat

Holzer‐Petsche

Lembeck

1984

British J Pharmacology

125

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“…Devamlı veya aralıklı oIarak idrarda kan görüImesi (makro veya mikro-hematuria), çok ve sık sık idrar dökme (Pollakuria), veya idrar yapamama, ya da yapmada güçlük çekme (Dysuria), idrar yapmayla iIgiIi (veya iIgisiz de oIabilen) bir acı duyma hissinin meydana çıkması en önemIi işaretIerdir (5,49,58). Sidik kesesi embryonaI hayatta mezo-ve endodermal tabakalardan köken alıp geçit epiteIi (transitional epithelium) ilc örtülü özel bir mukoza tabakasına sahip olduğu için, histolojik yapıları değişen iyi ve kötü huylu, çeşitli tümörlere köken oIabiIir.…”

Section: A Sidik Kesesi Tümörlerinin })Iyoloji Ve Lc-pidemiyolojisiunclassified

“…Sidik kesesi embryonaI hayatta mezo-ve endodermal tabakalardan köken alıp geçit epiteIi (transitional epithelium) ilc örtülü özel bir mukoza tabakasına sahip olduğu için, histolojik yapıları değişen iyi ve kötü huylu, çeşitli tümörlere köken oIabiIir. Bunların, Cetvel 2. de de gösterildiği gibi, % 98 ini kötü huyIu, kanserler teşkil eder (5,49,58,61,83,85). İnsanda kese kanseri çoğunlukla trigonumda, bir tek papillar lczyon halinde başlar ve zamanIa büyüyerek; karnı bahar şeklini alır (58--6 I).…”

Section: A Sidik Kesesi Tümörlerinin })Iyoloji Ve Lc-pidemiyolojisiunclassified

“…Operasyonlardan sonra sık sık nüks ettikleri gibi, yayılmaları sırasında kan veya lenf damarlarına girerek yakın veya uzak, diğer organlara metastaz yapabiIirler (5,8,49,58,61,83,85,127). Kese kanserlerinde metastaz olayına genel oIarak pek sık rastIanmaz isede, çevresel etkenlere iIgili olanlarda metastazlara çok yüksek oranda (% 8-17) rastlanabiIeceği bildirilmiştir (8,49,58,61,118,127). Gerek papiller, gerekse infiltratif kanserierİn, çok ilerledikleri olaylarda, aynı kesede çeşitI i şekil ve histolojik yapıda, kanseröz üremelere rastlanabilir (83,84).…”

Section: A Sidik Kesesi Tümörlerinin })Iyoloji Ve Lc-pidemiyolojisiunclassified

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