Urological profile of children with microcephaly and congenital zika syndrome

Campos, Ângelo de Medeiros Francilaide; Souza, Leonardo Azevedo de; Mattos, Adriana; Oliveira‐Filho, Jamary; Barroso, Ubirajara

doi:10.1016/j.jpurol.2020.10.011

Cited by 4 publications

(20 citation statements)

References 11 publications

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“…Moreover, in a later cohort study of Costa Monteiro et al (2019) [ 23 ], CZS was associated with neurogenic bladder, overactive bladder, urinary tract infection, and abnormal bladder capacity. In addition, a cohort study published by de Medeiros Francilaide Campos (2021) [ 24 ], a single urologist performed clinical, urological, urodynamical, laboratory, and ultrasonographical evaluations in 33 children with CSZ. Most of the patients did not have renal abnormalities and presented with a motif of undeveloped and reflex bladder, with non-significant post-void residual urine.…”

Section: Resultsmentioning

confidence: 99%

“…The surveys confirmed the neurogenic bladder in 100% of tested children. However, the study of Medeiros Francilaide Campos (2021) [ 24 ], disagrees with the methodology of the previous two studies belonging to the same researchers group. The authors argue that the former studies did not include the use of a rectal catheter and this could have contributed to a greater number of false-positive diagnoses of neurogenic bladder.…”

Section: Resultsmentioning

confidence: 99%

“…Certainly, the presence of microcephaly and its severity does not only affect the child’s nervous and developmental system. Until today, there are not enough reports on the effects of Zika virus on the urinary tract system and only a few studies and a case report have reported a possible correlation [ 22 , 23 , 24 , 26 , 39 , 40 ]. Urinary tract disorders are a common condition among children with CZS with severe microcephaly.…”

Section: Discussionmentioning

confidence: 99%

“…On a research level, it was observed that the mechanism of Zika virus infection induced acute kidney injury, increasing the levels of the related biomarkers in mice [ 40 ]. In addition, some cohorts have reported various disorders some of which are neurogenic bladder, urinary tract infections, bladder agenesis, and abnormal ultrasound findings [ 22 , 23 , 24 , 26 , 38 ], while further research is needed to understand the long-term behavior of Zika virus on the urinary track system. At this point, it should be mentioned that children with CZS are monitored from a very early age by many medical specialties, and it is a bit difficult to progress to kidney failure through neurogenic bladder, as it is a process that is often silent, but takes time to evolve.…”

Section: Discussionmentioning

confidence: 99%

“…Particularly, a study update observed to be clearly associated with detrusor over activity [ 23 ]. Writers concluded that there is no indication for patients with CZS to be regularly submitted to urodynamic control, and such an assessment should be carried out only when risk factors are present (pyelonephritis, ultrasound abnormalities) [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Congenital Zika Infection and the Risk of Neurodevelopmental, Neurological, and Urinary Track Disorders in Early Childhood. A Systematic Review

Antoniou

Orovou

Andronikidi³

et al. 2021

Viruses

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It was late 2015 when Northeast Brazil noticed a worrying increase in neonates born with microcephaly and other congenital malformations. These abnormalities, characterized by an abnormally small head and often neurological impairment and later termed Congenital Zika Syndrome, describe the severity of neurodevelopmental and nephrological outcomes in early childhood, and the implication of microcephaly at birth. The purpose of the study was to describe the neurodevelopmental outcomes in children exposed to Zika virus during fetal life, with and without microcephaly at birth. The systematic review included research studies about the neurodevelopmental outcomes with and without microcephaly, as well as nephrological outcomes in early childhood. We searched PubMed, Crossref, PsycINFO, Scopus, and Google Scholar publications and selected 19 research articles published from 2018 to 2021. Most studies have linked the severity of microcephaly in childbirth to the neurodevelopmental and urinary outcomes in early childhood. However, most children without microcephaly at birth develop typically, while others may be at risk for language impairment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Congenital Zika Infection and the Risk of Neurodevelopmental, Neurological, and Urinary Track Disorders in Early Childhood. A Systematic Review

Antoniou

Orovou

Andronikidi³

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil

Ferreira

Pinheiro

Melo

et al. 2022

Tropical Med Int Health

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Objective To describe the urological outcomes in children with congenital Zika syndrome (CZS) and investigate the relationship between clinical and urological findings in this population. Methods This cross‐sectional study involved children with CZS followed up by a referral centre for children with microcephaly in the state of Paraiba in northeast Brazil. The urological evaluation included clinical history, urine culture results, ultrasonography of the urinary tract, and urodynamic evaluation, following the protocol proposed by Costa Monteiro et al. (2017). Descriptive statistical analysis was performed in addition to association and correlation tests, considering clinical and urodynamic variables. Results Among the 88 children with CZS (35.5 ± 5.5 months), 97.7% had microcephaly, and 51% presented urinary tract infection (UTI) confirmed with clinical history and lab tests. The number of confirmed UTI episodes varied from one to 14 per child. The urodynamic evaluation confirmed the presence of an overactive bladder in 78 children and incomplete voiding in 50. Urodynamic findings were associated with the number of confirmed UTI episodes, child's sex, and actual weight, in addition to the use of anticonvulsant and myorelaxant drugs. Conclusions UTIs were confirmed in most children. Other urological outcomes observed were overactive bladder and low bladder capacity, which were associated with the number of confirmed UTI episodes, use of anticonvulsants and myorelaxants, and the child's sex and weight. These are treatable conditions, and it is paramount that paediatricians, neonatologists, and infectious disease specialists are aware of them to make clinical decisions and help reduce the risk of renal damage and other morbidities.

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Clinical spectrum of congenital Zika virus infection in Brazil: Update and issues for research development

Martelli,

Cortes,

Brandão-Filho

et al. 2024

Rev. Soc. Bras. Med. Trop.

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This review aimed to provide an update on the morphological and/or functional abnormalities related to congenital Zika virus (ZIKV) infection, based on primary data from studies conducted in Brazil since 2015. During the epidemic years (2015-2016), case series and pediatric cohort studies described several birth defects, including severe and/or disproportionate microcephaly, cranial bone overlap, skull collapse, congenital contractures (arthrogryposis and/or clubfoot), and visual and hearing abnormalities, as part of the spectrum of Congenital Zika Syndrome (CZS). Brain imaging abnormalities, mainly cortical atrophy, ventriculomegaly, and calcifications, serve as structural markers of CZS severity. Most case series and cohorts of microcephaly have reported the co-occurrence of epilepsy, dysphagia, orthopedic deformities, motor function impairment, cerebral palsy, and urological impairment. A previous large meta-analysis conducted in Brazil revealed that a confirmed ZIKV infection during pregnancy was associated with a 4% risk of microcephaly. Additionally, one-third of children showed at least one abnormality, predominantly identified in isolation. Studies examining antenatally ZIKV-exposed children without detectable abnormalities at birth reported conflicting neurodevelopmental results. Therefore, long-term follow-up studies involving pediatric cohorts with appropriate control groups are needed to address this knowledge gap. We recognize the crucial role of a national network of scientists collaborating with international research institutions in understanding the lifelong consequences of congenital ZIKV infection. Additionally, we highlight the need to provide sustainable resources for research and development to reduce the risk of future Zika outbreaks.

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Urological profile of children with microcephaly and congenital zika syndrome

Cited by 4 publications

References 11 publications

Congenital Zika Infection and the Risk of Neurodevelopmental, Neurological, and Urinary Track Disorders in Early Childhood. A Systematic Review

Congenital Zika Infection and the Risk of Neurodevelopmental, Neurological, and Urinary Track Disorders in Early Childhood. A Systematic Review

Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil

Clinical spectrum of congenital Zika virus infection in Brazil: Update and issues for research development

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