Uromodulin as a potential candidate marker for predicting the course of chronic kidney disease

Denova, L.D.

doi:10.22141/2307-1257.10.4.2021.247898

Cited by 5 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Umod попереджає утворення мікробних біоплівок (в тому числі Esherichia coli) дякуючи здатності зв'язуючись з типом 1 фімбрій кишкової палички. Дієта з великим вмістом білка і солі, а, також, петльові діуретики стимулюють секрецію Umod [15,41].…”

Section: приміткиunclassified

See 1 more Smart Citation

Development of renal fibrosis in patients with chronic kidney disease: Mechanisms, biomarkers, and clinical implications

Denova

2023

Ukr. J. Nephrol. and Dial.

Self Cite

View full text Add to dashboard Cite

CKD is a global health concern with significant implications for patients' well-being, morbidity, and mortality. The underlying mechanism of CKD development often involves progressive interstitial fibrosis. Understanding the processes and factors influencing fibrogenesis is crucial. This review aims to analyze recent literature on the pathophysiological mechanisms, early diagnosis, prevention, and treatment of renal fibrosis in CKD patients. It explores various aspects of kidney fibrogenesis, highlighting key pathogenic factors and signaling pathways that warrant further investigation. The review emphasizes the potential of urinary uromodulin (uUmod) as a biomarker for early renal fibrosis diagnosis and delves into the role of anemia, kidney hypoxia, vitamin D, and unique aspects of fibrosis development in diabetic kidney disease patients. Furthermore, it underscores the importance of inhibiting the renin-angiotensin-aldosterone system (RAAS) as a strategy for fibrosis prevention and attenuation.

show abstract

Section: приміткиunclassified

“…Причиною Umod-накопичувальних хвороб є мутації в гені UMOD. Виявлено асоціацію ХХН з поодинокими нуклеатидними поліморфізмами в гені UMOD, рівень сироваткового Umod (sUmod) підвищувався [15,41].…”

Section: приміткиunclassified

Development of renal fibrosis in patients with chronic kidney disease: Mechanisms, biomarkers, and clinical implications

Denova

2023

Ukr. J. Nephrol. and Dial.

Self Cite

View full text Add to dashboard Cite

show abstract

“…ХХН діагностують, якщо розрахункова швидкість клубочкової фільтрації (рШКФ) протягом 3 місяців і більше становить менше за 60 мл/хв на 1,73 м 2 і/або співвідношення альбуміну і креатиніну (САК) -понад 30 мг/г [2,5,10]. Існує п'ять стадій (1-5) ХХН, які визначають на підставі рШКФ.…”

Section: вступunclassified

“…Уромодулін сечі (uUmod) є біомаркером тубулярної маси та функції канальців (функціональний тубулярний маркер) у загальній популяції та в окремих групах (табл. 1) [4,5].…”

Section: вступunclassified

Evaluation of the index of resistance and excretion of uromodulin in patients with predialysis chronic kidney disease, taking into account the index of comorbidity

Denova

Ivanov

2023

KIDNEYS

Self Cite

View full text Add to dashboard Cite

Background. The purpose of this study was to investigate urinary uromodulin (uUmod) excretion, reactivity of the autonomic nervous system and impaired renal blood circulation in patients with predialysis chronic kidney disease (CKD), and the effect of antioxidant therapy on these parameters. Materials and methods. Ninety-one patients with CKD stage 1–5 took part in the ROLUNT (UROmoduLin UbiquinoNe GlutaThione) study, their average age was 47.00 ± 12.12 years. Thirty (32.97 %) men and 61 (67.03 %) women were divided into two groups, which were representative in terms of age and gender composition: the first one (n = 46) — patients with CKD stage1–5 who had Charlson Comorbidity Index ≤ 2, the second one (n = 45) — patients with CKD stage1–5 who had Charlson Comorbidity Index ≥ 3. The first and second groups were divided into subgroups A and B. Subgroup A included patients with impaired vegetative status, subgroup B — without impaired vegetative status. Subgroups 1A and 2B took glutathione 100 mg twice a day with food for 3 months; subgroups 1B and 2A received ubiquinone 100 mg once a day with food for 3 months. In patients with CKD stage1–5, uUmod, albumin to creatinine ratio (ACR), glomerular filtration rate (GFR) were evaluated. Ninety-one ultrasound duplex color scans of the kidneys were performed and the index of resistance (IR) was determined in patients with CKD stage1–5. Results. The results of the paired t-test showed that there is a significant difference between the indicators at the beginning and at the end of the study, with the exception of the following: in subgroup 1A: hemoglobin (Hb) (T = –1.5863 [–2.0739, 2.0739] 95% confidence interval (CI) [–2.4077, 0.3207], p = 0.127); in subgroup 1B: Hb (T = –0.382 [–2.0739, 2.0739], 95% CI [–1.3977, 0.963], p = 0.706); ACR (T = –1.5899 [–2.0739, 2.0739], 95% CI [–16.7323, 2.2105], p = 0.126); systolic blood pressure (SBP) (T = –0.5625 [–2.0739, 2.0739], 95% CI [–2.2414, 1.2849], p = 0.579); diastolic blood pressure (DBP) (T = –1.7936 [–2.0739, 2.0739], 95% CI [–2.3437, 0.1698], p = 0.087); Chernov questionnaire (T = 1.5071 [–2.0739, 2.0739], 95% CI [–0.6083, 3.8431], p = 0.146); Kérdö index (T = 0.9392 [–2.0739, 2.0739], 95% CI [–1.1083, 2.9431], p = 0.358); in subgroup 2A: ACR (T = –2.0147 [–2.0796, 2.0796], 95% CI [–39.1946, 0.6219], p = 0.057); in subgroup 2B: ACR (T = –1.3328 [–2.0739, 2.0739], 95% CI [–17.4695, 3.7999], p = 0.196). The Pearson correlation results showed that in subgroup 1A, there is a significant average positive relationship between uUmod and eGFR (r(21) = 0.418, p = 0.047); a significant very small negative relationship between uUmod indicators and age (r(21) = 0.438, p = 0.037); in subgroup 1B, there is a significant large positive relationship between uUmod and Hb indicators (r(21) = 0.513, p = 0.012); a significant positive relationship between uUmod and Morisky Medication Adherence Scale-8 (MMAS-8) indicators (r(21) = 0.515, p = 0.012); a significant very small negative relationship between uUmod and ACR indicators (r(21) = 0.441, p = 0.035); in subgroup 2A, there is a significant very small negative relationship between uUmod indicators and Kérdö index (r(20) = 0.427, p = 0.048); in subgroup 2B, there is a significant very small negative relationship between the uUmod indicators and Chernov questionnaire score (r(21) = 0.421, p = 0.045); a significant very small negative relationship between uUmod indicators and Charlson Comorbidity Index (r(21) = 0.481, p = 0.020); a significant very small negative relationship between uUmod and age (r(21) = 0.471, p = 0.023). In subgroup 1A at the end of the study, the following independent variables are not significant as predictors for uUmod: IRd, IRs, SBP, DBP, Hb, ACR, age, Vein and Chernov questionnaires score, MMAS-8, Charlson Comorbidity Index and Kérdö index. In subgroup 1B at the end of the study, the following independent variables are not significant as predictors for uUmod: eGFR, IRs, SBP, DBP, Hb, Vein and Chernov questionnaires score, MMAS-8, Charlson Comorbidity Index and Kérdö index. In subgroup 2A at the end of the study, the following independent variables are not significant as predictors for uUmod: eGFR, IRd, IRs, SBP, DBP, Hb, ACR, age, Vein questionnaire score, MMAS-8, Charlson Comorbidity Index. In subgroup 2B at the end of the study, the following independent variables are not significant as predictors for uUmod: eGFR, IRd, IRs, SBP, DBP, Hb, ACR, age, Vein questionnaire score, MMAS-8, Kérdö index. Conclusions. Antioxidant therapy with glutathione and ubiquinone significantly affects the examination parameters of patients with CKD. Considering the safety and effectiveness of antioxidant therapy, we suggest including antioxidant therapy into the treatment protocols for patients with CKD. Further research is recommended to establish a standard protocol.

show abstract

“…Пошук нових «ранніх» біомаркерів виникнення і прогресування ХХН є дуже актуальним і перспектив ним [50,51].…”

Section: запрошені статті / Guest Articlesunclassified

Nephrological care in the conditions of martial law in Ukraine

Denova

Ivanov

Andrunevich

et al. 2022

KIDNEYS

Self Cite

View full text Add to dashboard Cite

During armed conflicts (AC) and other disasters, the elderly, women, children, the infirm and the chronically ill patients are the most vulnerable population, with a high risk to health and life. Chronically ill people with kidney diseases, including those with kidney failure, deserve special attention due to their complete dependence on available functional infrastructure, and access to vital drugs and well-trained personnel. Currently, there is little information on the effects of AC on patients with kidney damage compared to the available data about the effects of other disasters. Mechanisms of injuries in AC and natural or man-made disasters have similar and distinctive features. Distinctive features: during AC — mainly gunshot and mine blast injuries, bleedings, poisonings by toxic substances, during disasters — hypothermia or burns, mechanical injuries, etc. Similar features include damage to infrastructure, particularly health care facilities, shortage of medicines, medical personnel, humanitarian and other crises, and a large number of injured and traumatized people in the hospitals. In this article, we systematized the material obtained during the military conflict, as well as reviewed domestic and foreign articles on this topic in order to optimize the work of nephrologists in the conditions of martial law and limited resources.

show abstract

Uromodulin as a potential candidate marker for predicting the course of chronic kidney disease

Cited by 5 publications

References 46 publications

Development of renal fibrosis in patients with chronic kidney disease: Mechanisms, biomarkers, and clinical implications

Development of renal fibrosis in patients with chronic kidney disease: Mechanisms, biomarkers, and clinical implications

Evaluation of the index of resistance and excretion of uromodulin in patients with predialysis chronic kidney disease, taking into account the index of comorbidity

Nephrological care in the conditions of martial law in Ukraine

Contact Info

Product

Resources

About