The central purpose of the present investigation was the qualitatively and quantitatively analyze the glycosaminoglycans of guinea pig skin at 2 hr after a third-degree burn injury. The data obtained from uronic acid determinations, fractionation by column chromatography and cellulose acetate electrophoresis indicate no significant alterations in the glycosaminoglycans at 2 hr postburn. The data presented in this study support the concept that the glycosaminoglycans are not immediately damaged by the heat of the burn.
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