Urotensin II levels in patients with chronic kidney disease and kidney transplants

Hurşitoğlu, Mehmet; Tükek, Tufan; Çıkrıkçıoğlu, Mehmet Ali; Kara, Osman; Kazancıoğlu, Rümeyza; Özkan, Oktay; Çakırca, Mustafa; Akdogan, Fatih; Gundogan, Erdal; Aydin, Sengul; Beycan, İsmet; Gürsu, Meltem; Doğan, Serkan; Erek, Aybala

doi:10.3109/03009734.2011.626541

Cited by 7 publications

(6 citation statements)

References 26 publications

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“…This could not be explained solely by the transplanted kidney, because UII levels were higher than healthy controls and It was assumed that this could be immunosuppressive drug-related. However, the immunosuppressive drug doses and the duration of transplantation did not correlate with UII levels [39]. In our study, RTR children had significantly higher UII levels compared to healthy controls and higher but without statistical significance UII levels than CKD patients.…”

Section: Discussioncontrasting

confidence: 52%

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Plasma Urotensin II levels in children and adolescents with chronic kidney disease: a single-centre study

et al. 2017

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BackgroundIncreased plasma Urotensin II (UII) levels have been found in adults with renal diseases. Studies in children are scarce. The objective of the study is to estimate plasma UII levels in subjects with chronic kidney disease (CKD) stages 3 to 5 and renal transplant recipients (RTR). In addition, the correlation of UII with anthropometric features and biochemical parameters was assessed.MethodsFifty-four subjects, aged 3 to 20 years old, 23 with CKD, 13 with end-stage kidney disease (ESKD) undergoing hemodialysis (HD) and 18 RTR were enrolled. A detailed clinical evaluation was performed. Biochemical parameters of renal and liver function were measured. Plasma UII levels were measured in all patients and in 117 healthy controls, using a high sensitive enzyme immunoassay (EIA) kit. All data were analyzed using STATA™ (Version 10.1).ResultsMedian UII and mean log-transformed UII levels were significantly higher in CKD and RTR patients compared to healthy subjects (p < 0.001). HD patients had higher but not statistically significant UII and log-UII levels than controls. UII levels increased significantly at the end of the HD session and were higher than controls and in line to those of other patients. The geometric scores of UII in HD (before dialysis), CKD and RTR patients increased respectively by 42, 136 and 164% in comparison with controls. Metabolic acidosis was associated with statistical significant change in log-UII levels (p = 0.001). Patients with metabolic acidosis had an increase in UII concentration by 76% compared to those without acidosis.ConclusionsChildren and adolescents with CKD, particularly those who are not on HD and RTR, have significantly higher levels of UII than healthy subjects. UII levels increase significantly at the end of the HD session. The presence of metabolic acidosis affects significantly plasma UII levels.

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Section: Discussioncontrasting

confidence: 52%

“…This is in accordance with most of the above mentioned studies [ 9 , 36 , 45 ]. On the contrary, a significant correlation between age and UII has been reported [ 6 ] and Hurshitoglu et al [ 39 ] observed that males tended to have higher levels of UII than females.…”

Section: Discussionmentioning

confidence: 99%

Plasma Urotensin II levels in children and adolescents with chronic kidney disease: a single-centre study

et al. 2017

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“…Studies suggested that it can induce a pro-atherothrombotic phenotype in human coronary endothelial cells and can be used as a biomarker predicting the adverse cardiovascular events. [41,42] Urotensin II (UT-II), which plays an important role in CKD, [43] is involved with endothelial dysfunction and coronary thrombosis. [44] It probably represents a key link between CKD and CAD.…”

Section: Discussionmentioning

confidence: 99%

Serum angiopoietin-2 concentrations of post-PCI are correlated with the parameters of renal function in patients with coronary artery disease

Wen¹,

Wei

et al. 2019

Medicine

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Patients with coronary artery disease (CAD) frequently have comorbidity of chronic kidney disease (CKD). Their renal function may deteriorate because of the use of contrast agent after percutaneous coronary intervention (PCI). Angiopoietin-2 (Ang-2), which is highly expressed in the site of angiogenesis, plays an important role in both CAD and CKD. This study aimed to investigate the relation of serum Ang-2 concentrations with the renal function after PCI.This study enrolled 57 patients with CAD undergoing PCI. Blood samples for Ang-2 were collected in the first morning after admission and within 24 to 48 h after PCI. The parameters of renal function (serum creatinine, cystatin C and eGFR) were tested on the first day after admission and within 72 h after PCI.Overall, serum Ang-2 levels of post-PCI were significantly lower than those of pre-PCI [median, 1733 (IQR, 1100–2568) vs median, 2523 (IQR, 1702–3640) pg/mL; P < .001]. However, in patients with CKD (eGFR < 60 mL/min/1.73 m2), there was no significant difference between serum Ang-2 levels of post-PCI and those of pre-PCI [median, 2851 (IQR, 1720–4286) vs. median, 2492 (IQR, 1434–4994) pg/mL; P = .925]. In addition, serum Ang-2 levels of post-PCI, but not pre-PCI, were significantly correlated with the post-PCI parameters of renal function.Serum Ang-2 concentrations of post-PCI are closely related to renal function in patients with CAD. It may have potential to be the early biomarker of contrast-induced nephropathy in the future.

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“…The vasoactive peptide UII has been shown to be increased in several disease conditions as hypertension, heart failure, atherosclerosis, kidney failure, etc. Surprisingly, its plasma levels were found to be higher in patents underwent kidney transplant than chronic renal failure and healthy control subjects [11]. In addition to its vasoactive effect, it also has a diabetogenic effect [3,4].…”

Section: Discussionmentioning

confidence: 97%

“…Routine laboratory tests were performed in our hospital's laboratory and plasma UII level was determined in Ahenk Laboratory (Istanbul, Turkey). The details of blood sample collection for UII and its determination were discussed elsewhere [11].…”

Section: Methodsmentioning

confidence: 99%

Plasma Urotensin II Concentration In Gestational Diabetes

Hurşitoğlu¹,

Ekiz²,

Mete³

et al. 2017

Archives of Clinical and Experimental Medicine

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Aim: Urotensin II (UII) and its system is implicated in the etiology of many diseases (including diabetes mellitus). We tried in this study to evaluate and compare UII levels in gestational diabetes mellitus (GDM). Methods: Thirty-six pregnant women (15 non-GDM patients consisted group 1 and 21 GDM patients consisted group 2) enrolled in this study. The 3rd group consisted of age matched 22 non pregnant healthy women. Plasma UII levels were determined at the beginning of the study. After 12 weeks of delivery, a second plasma UII was determined from group 1 and 2. Results: Gestational UII levels of both GDM and non-GDM patients were higher than non-pregnant healthy controls (p=0.0001 for both). Both gestational and postpartum UII levels of GDM patients were higher than non-GDM patients but had not reached statistical significance (P≥0.05). Plasma UII concentrations in non-GDM patients significantly decreased after delivery but not in GDM patients (p=0.036 and p≥0.05, respectively) Conclusions: The finding of elevated gestational plasma UII concentrations in GDM patients which did not decrease significantly after delivery (in compare to non-GDM patients) shows that plasma UII levels may have a role in the pathogenesis of GDM. Further detailed studies are needed in this field.

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Urotensin II levels in patients with chronic kidney disease and kidney transplants

Cited by 7 publications

References 26 publications

Plasma Urotensin II levels in children and adolescents with chronic kidney disease: a single-centre study

Plasma Urotensin II levels in children and adolescents with chronic kidney disease: a single-centre study

Serum angiopoietin-2 concentrations of post-PCI are correlated with the parameters of renal function in patients with coronary artery disease

Plasma Urotensin II Concentration In Gestational Diabetes

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