Urothelial Carcinoma Recurrence in an Ileal Neobladder Nine Years after Primary Surgery with Muir-Torre Syndrome

Cherbanyk, Floryn; Prod’homme, Marc; Pezzetta, Edgardo; Chevaux, Bernard; Anaye, Anass; Boillat, Jean-Joseph

doi:10.1155/2016/4762514

Cited by 8 publications

(11 citation statements)

References 12 publications

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“…Two CIS of the ileum had been reported [ 24 , 26 ]. Treatment of the TCCUD was radiation therapy in 1/30 [ 7 ], endoscopic resection/biopsy in 4/30 [ 25 , 30 , 31 , 33 ], partial resection of the urinary diversion in 12/30 [ 8 , 9 , 10 , 12 , 14 , 15 , 17 , 19 , 20 , 22 , 23 , 29 ] and a complete resection of the urinary diversion in 11/30 [ 7 , 11 , 13 , 16 , 24 , 26 - 28 , 32 , 34 , 35 ]. Only two cases were not surgically treated and underwent palliation with RT/chemotherapy [ 18 , 21 ].…”

Section: Resultsmentioning

confidence: 99%

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Transitional cell carcinoma recurrence impacting intestinal diversion after radical cystectomy. Oncologic outcomes of a rare site of recurrence

Zattoni¹,

Bednarova

Morlacco

et al. 2020

Cent european J Urol

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Introduction Transitional cell carcinoma recurrence within an intestinal urinary diversion (TCCUD) after radical cystectomy (RC) is a rare condition with unknown origin, prognosis and treatment. The aim of this study was to describe treatment options and oncologic outcomes of this understudied site of recurrence in a multi-institutional case series. Material and methods TCCUD relapse cases after RC were investigated in a retrospective, multi-institutional study. Surgical approach and adjuvant chemotherapy were discussed. Early and late complications were described according to the Clavien-Dindo classification. Kaplan-Meier method was used to assess progression-free and cancer-specific survival. Results A total of 19 patients were selected. The most common presentation was gross hematuria. The median interval between RC and TCCUD was 51.2 months. Fifteen patients (78.9%) underwent surgical excision, and two underwent concomitant radical nephroureterectomy. In 12 (63.1%) cases the site of TCCUD was the uretero-ileal anastomosis. Tumor invading the muscularis of the intestinal diversion was described in 10 (52.6%) cases. Surgical complications occurred in 7/15 (46.6%) patients, of these two with Clavien-Dindo Grade III. Four patients (21.0%) underwent adjuvant chemotherapy and two (10.5%) both chemotherapy and radiation therapy. During follow-up 15 patients (78.9%) presented with other sites of recurrence, with lymph nodes (21.0%) and liver (15.7%) being the most common localizations. Recurrence free and overall survival rates were 36.8% and 15.8%, and 56.5% and 24.2%, respectively at 12 and 18 months. Conclusions Most patients with TCCUD have invasive disease and a substantial percentage experience upper tract cancer during their disease course. TCCUD is often the herald of advanced disease and systemic progression, with poor progression-free and overall survival rates.

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Section: Resultsmentioning

confidence: 99%

“…Additional therapy to surgery were the instillation of Bacillus Calmette-Guerin (BCG) into the ileal reservoir [ 30 ], systemic chemotherapy [ 9 , 15 , 18 , 19 , 20 , 27 , 32 , 33 ], radiation therapy [ 21 ], combination of chemotherapy + radiation therapy [ 22 ] or chemotherapy + retroperitoneal lymphadenectomy [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Transitional cell carcinoma recurrence impacting intestinal diversion after radical cystectomy. Oncologic outcomes of a rare site of recurrence

Zattoni¹,

Bednarova

Morlacco

et al. 2020

Cent european J Urol

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“…An isolated recurrence of urothelial carcinoma in an ileal neobladder without involvement of the upper tract or urethra is rare. To our knowledge, only 3 case reports have been previously published in the literature ( Table 1 ) [ 9 – 11 ]. Patients may present with new hydronephrosis and gross hematuria or as in our case have an abnormal urine cytology.…”

Section: Discussionmentioning

confidence: 99%

Urothelial Carcinoma Recurrence in an Orthotopic Neobladder without Urethral or Upper Urinary Tract Involvement

Doshi

Barkan

Quek

2019

Case Reports in Urology

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We describe a case of a 71-year-old male with an isolated recurrence of urothelial carcinoma in an ileal neobladder without involvement of the upper urinary tract or urethra. He was diagnosed with high grade urothelial carcinoma involving a bladder diverticulum with associated carcinoma in situ. He underwent a radical cystectomy and orthotopic Studer ileal neobladder. On routine follow-up, 11 years following cystectomy, voided urine cytology was positive for high grade urothelial carcinoma. Further workup revealed normal upper urinary tracts, normal urethra, and a solitary lesion at the left anteroinferior wall of the neobladder. He subsequently underwent resection of the neobladder and conversion to an ileal conduit with pathology confirming the diagnosis of high grade urothelial carcinoma. Isolated recurrence of urothelial carcinoma within a neobladder without involvement of the upper urinary tract or urethra is rare. No guidelines exist regarding its management. Herein we present our management as well as the current literature published on this topic.

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“…Recurrence occurs after transurethral resection (TUR) of superficial bladder tumors in about 70% of patients [ 95 ]. However, in radical cystectomy with ileal-w-neo bladder, using a portion of the ilium, adenocarcinomas may develop due to intestinal mucosal irritation by prolonged contact with urine, which is considered as a secondary malignancy to primary urothelial cancer ( Figure 14 ) [ 96 ].…”

Section: Recurrencementioning

confidence: 99%

Imaging of Bladder Cancer: Standard Applications and Future Trends

et al. 2021

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The evolution in imaging has had an increasing role in the diagnosis, staging and follow up of bladder cancer. Conventional cystoscopy is crucial in the diagnosis of bladder cancer. However, a cystoscopic procedure cannot always depict carcinoma in situ (CIS) or differentiate benign from malignant tumors prior to biopsy. This review will discuss the standard application, novel imaging modalities and their additive role in patients with bladder cancer. Staging can be performed with CT, but distinguishing between T1 and T2 BCa (bladder cancer) cannot be assessed. MRI can distinguish muscle-invasive from non-muscle-invasive tumors with accurate local staging. Vesical Imaging-Reporting and Data System (VI-RADS) score is a new diagnostic modality used for the prediction of tumor aggressiveness and therapeutic response. Bone scintigraphy is recommended in patients with muscle-invasive BCa with suspected bony metastases. CT shows low sensitivity for nodal staging; however, PET (Positron Emission Tomography)/CT is superior and highly recommended for restaging and determining therapeutic effect. PET/MRI is a new imaging technique in bladder cancer imaging and its role is promising. Texture analysis has shown significant steps in discriminating low-grade from high-grade bladder cancer. Radiomics could be a reliable method for quantitative assessment of the muscle invasion of bladder cancer.

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Urothelial Carcinoma Recurrence in an Ileal Neobladder Nine Years after Primary Surgery with Muir-Torre Syndrome

Abstract: We report a patient who presented with a urothelial carcinoma recurrence developed nine years after radical cystoprostatectomy, related to Muir-Torre syndrome.

Cited by 8 publications

References 12 publications

Transitional cell carcinoma recurrence impacting intestinal diversion after radical cystectomy. Oncologic outcomes of a rare site of recurrence

Transitional cell carcinoma recurrence impacting intestinal diversion after radical cystectomy. Oncologic outcomes of a rare site of recurrence

Urothelial Carcinoma Recurrence in an Orthotopic Neobladder without Urethral or Upper Urinary Tract Involvement

Imaging of Bladder Cancer: Standard Applications and Future Trends

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