1995
DOI: 10.1016/0016-5085(95)90407-7
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Ursodeoxycholate increases cytosolic calcium concentration and activates CI− currents in a biliary cell line

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Cited by 53 publications
(39 citation statements)
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“…Mz-ChA-1 cells are very well characterized models of BDE proliferation (46,47). For these reasons, Mz-ChA-1 cells have been studied extensively, and their similarities to primary BDE are well known (22,48). Furthermore, we have validated the use of Mz-ChA-1 cells for these experiments by repeating our initial findings of the effects of PF co-culture on primary BDE.…”
Section: Discussionmentioning
confidence: 56%
“…Mz-ChA-1 cells are very well characterized models of BDE proliferation (46,47). For these reasons, Mz-ChA-1 cells have been studied extensively, and their similarities to primary BDE are well known (22,48). Furthermore, we have validated the use of Mz-ChA-1 cells for these experiments by repeating our initial findings of the effects of PF co-culture on primary BDE.…”
Section: Discussionmentioning
confidence: 56%
“…23,26 The therapeutic efficacy of UDCA remains, however, incompletely understood, and yet another mechanism that has been hypothesized is that UDCA may act on biliary epithelial cells directly and affect their secretory functions. Although a previous study showed that UDCA had no effect on the anion exchanger activity that mediates bicarbonate-rich choleresis, in the SK-ChA-1 biliary epithelial cell line, 27 it has also been reported that high concentrations of UDCA could stimulate chloride conductance in another biliary epithelial cell line (Mz-ChA-1), 28 consistent with direct effects of UDCA on biliary epithelial cells.…”
mentioning
confidence: 77%
“…Although it was previously shown that UDCA at high concentration activates chloride conductance in the Mz-ChA-1 cell line, 28 this is the first evidence that conjugated bile acids below the critical micellar concentration 46 induce chloride secretion in BEC. Bile acid-induced chloride and mucin secretion was to a large extent sodium-dependent, consistent with HEPATOLOGY Vol.…”
Section: Discussionmentioning
confidence: 98%
“…Therefore, most plausibly, BS accumulation in ASBT-carrying ileocytes activates CFTR directly, via a relay mechanism within the same cell or via paracrine signaling between epithelial cells. For cholangiocarcinoma cells (46) and T84 colonic tumor cells (17), it was shown that certain BS may evoke Cl Ϫ secretion by enhancing Ca 2ϩ release from intracellular stores. In the intestinal epithelium, Ca 2ϩ agonists induce secretion principally by activation of basolaterally situated K ϩ channels.…”
Section: Discussionmentioning
confidence: 99%