Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes

Saraswat, Binduja; Visen, P. K. S.; Agarwal, D. P.

doi:10.1002/(sici)1099-1573(200005)14:3<163::aid-ptr588>3.0.co;2-d

Cited by 67 publications

(35 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several researchers have also evaluated the cytotoxic effects of ursolic acid and eichlerianic acid [18][19][20][21] isolated from other plant species in several cancer cell lines including MCF-7 breast cancer cells [22,23] and those results are some …”

Section: Discussionmentioning

confidence: 99%

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Samarakoon¹,

Ediriweera²,

Wijayabandara³

et al. 2018

Trop. J. Pharm Res

View full text Add to dashboard Cite

and two-dimensional nuclear magnetic resonance (2D-NMR) and electron ionization-mass spectrometry (EI-MS) techniques. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to evaluate the cytotoxic effects of the compounds on oestrogen receptor positive breast (MCF-7) and non-small cell lung (NCI-H-292) cancer cells. Results: The isolated compounds were identified as oleanolic acid (1), ursolic acid (2) and eichlerianic acid (3). Ursolic acid and eichlerianic acid showed strong cytotoxic effects {IC50-ursolic acid: 8.47 µg/mL (24 h, MCF-7), 7.78 µg/mL (24 h, NCI-H292) and eichlerianic acid: 8.86 µg/mL (24 h, MCF-7), 10.15 µg/mL (24 h, NCI-H292)} in MCF-7 and NCI-H292 cancer cells at 24, 48 and 72 h post-incubation periods. Conclusion: Hexane and chloroform extracts of the leaves of S. hydrophyllacea yielded three compounds namely oleanolic acid, eichlerianic acid and ursolic acid. Ursolic acid and eichlerianic acid have been isolated for the first time from the leaves of S. hydrophyllacea grown in Sri Lanka and demonstrate in-vitro cytotoxic effects in oestrogen receptor positive (MCF-7) and non-small lung cancer (NCI-H-292) cells.Keywords: Scyphiphora hydrophyllacea, eichlerianic acid, ursolic acid, oleanolic acid, This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest

show abstract

Section: Discussionmentioning

confidence: 99%

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Samarakoon¹,

Ediriweera²,

Wijayabandara³

et al. 2018

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…Ursolic acid and its isomer, oleanolic acid, are triterpenoid compounds found across the vegetal kingdom that have anti-inflammatory, anti-arthritic, cytostatic, antiproliferative, and hepato-protective effects in mice, as well as membrane stabilizing properties [161][162][163].…”

Section: Plant-derived Agents With Anti-glycation Activity 239mentioning

confidence: 99%

Plant-Derived Agents with Anti-Glycation Activity

Odjakova¹,

Popova²,

Sharif³

et al. 2012

Glycosylation

View full text Add to dashboard Cite

“…It has broad bioactive use including antifungal, antiinflammatory, antiulceric, antihyperlipidemic, antihyperglycemic, and antitumorgenic activity (Yan et al, 2010;Liu, 1995;Gayathri et al, 2009 (Ma et al, 1986;Lin et al, 1988;Liu et al, 1994;Saraswat et al, 2000;Ovesna et al, 2004). However, the potential role of UA in liver regeneration has not been studied.…”

Section: Introductionmentioning

confidence: 99%

Ursolic acid enhances mouse liver regeneration after partial hepatectomy

Jin

et al. 2011

Pharmaceutical Biology

View full text Add to dashboard Cite

Ursolic acid isolated from Eucalyptus tereticornis protects against ethanol toxicity in isolated rat hepatocytes

Cited by 67 publications

References 10 publications

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Isolation of cytotoxic triterpenes from the mangrove plant, <i>Scyphiphora hydrophyllacea</i> C.F.Gaertn (Rubiaceae)

Plant-Derived Agents with Anti-Glycation Activity

Ursolic acid enhances mouse liver regeneration after partial hepatectomy

Contact Info

Product

Resources

About